Open reading frame 3 protein of hepatitis E virus: Multi-function protein with endless potential

Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication

(2020) Xiaohui Ju et al.   PLoS Pathogens

Dissecting the potential role of hepatitis E virus ORF1 nonstructural gene in cross‐species infection by using intergenotypic chimeric viruses

(2020) Debin Tian et al.   JOURNAL OF MEDICAL VIROLOGY

Hepatitis E Virus: How It Escapes Host Innate Immunity

(2020) Sébastien Lhomme et al.   Vaccines

Replication and virulence in pigs of the first African swine fever virus isolated in China

(2019) Dongming Zhao et al.   Emerging Microbes & Infections

Genome sequences derived from pig and dried blood pig feed samples provide important insights into the transmission of African swine fever virus in China in 2018

(2019) Xuexia Wen et al.   Emerging Microbes & Infections

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

(2019) Maliki Ankavay et al.   Scientific Reports

The 40 kDa Linear Polyethylenimine Inhibits Porcine Reproductive and Respiratory Syndrome Virus Infection by Blocking Its Attachment to Permissive Cells

(2019) Jie Wang et al.   Viruses-Basel

Architecture of African swine fever virus and implications for viral assembly

(2019) Nan Wang et al.   SCIENCE

MYH9 Key Amino Acid Residues Identified by the Anti-Idiotypic Antibody to Porcine Reproductive and Respiratory Syndrome Virus Glycoprotein 5 Involve in the Virus Internalization by Porcine Alveolar Macrophages

(2019) Liangliang Li et al.   Viruses-Basel

Neurologic complications of acute hepatitis E virus infection

(2019) Paolo Ripellino et al.   Neurology-Neuroimmunology & Neuroinflammation

Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein

(2018) Claire Montpellier et al.   GASTROENTEROLOGY

Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection

(2018) Xin Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of hepatitis E virus infection on interferon production via ISG15

(2018) Min Wang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

HEV ORF3 downregulates TLR7 to inhibit the generation of type I interferon via impairment of multiple signaling pathways

(2018) Qingsong Lei et al.   Scientific Reports

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

(2018) Jérôme Gouttenoire et al.   PLoS Pathogens

The hepatitis E virus nonstructural polyprotein

(2017) Mohammad Khalid Parvez   Future Microbiology

Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway

(2017) Shigeo Nagashima et al.   JOURNAL OF VIROLOGY

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

(2017) Qiang Ding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of recombinant Chinese avian hepatitis E virus (CaHEV) ORF2 and ORF3 proteins for protection of chickens against CaHEV infection

(2017) Shahid Faraz Syed et al.   VACCINE

Seroprevalence of hepatitis E virus differs in Dutch and first generation migrant populations in Amsterdam, the Netherlands: a cross-sectional study

(2016) S. Sadik et al.   BMC INFECTIOUS DISEASES

Chronic Infection With Camelid Hepatitis E Virus in a Liver Transplant Recipient Who Regularly Consumes Camel Meat and Milk

(2016) Guan-Huei Lee et al.   GASTROENTEROLOGY

Hepatitis E Virus Circulation in Italy: Phylogenetic and Evolutionary Analysis

(2016) Carla Montesano et al.   Hepatitis Monthly

Hepatitis E virus (HEV)-1 harbouring HEV-4 non-structural protein (ORF1) replicates in transfected porcine kidney cells

(2016) Subhashis N. Chatterjee et al.   JOURNAL OF GENERAL VIROLOGY

Detection and assessment of infectivity of hepatitis E virus in urine

(2016) Yansheng Geng et al.   JOURNAL OF HEPATOLOGY

Hepatitis E virus as an emerging zoonotic pathogen

(2016) Woo-Jung Park et al.   Journal of Veterinary Science

Distinct Entry Mechanisms for Nonenveloped and Quasi-Enveloped Hepatitis E Viruses

(2016) Xin Yin et al.   JOURNAL OF VIROLOGY

Causation by HEV of extrahepatic manifestations remains unproven

(2016) Zongdi Feng   LIVER INTERNATIONAL

A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus

(2016) Yonglin Yang et al.   Viruses-Basel

Zoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission Routes

(2016) Virginie Doceul et al.   Viruses-Basel

Expanding Host Range and Cross-Species Infection of Hepatitis E Virus

(2016) Xiang-Jin Meng   PLoS Pathogens

Endoplasmic Reticulum Stress Induced Synthesis of a Novel Viral Factor Mediates Efficient Replication of Genotype-1 Hepatitis E Virus

(2016) Vidya P. Nair et al.   PLoS Pathogens

Transcriptome Analysis of HepG2 Cells Expressing ORF3 from Swine Hepatitis E Virus to Determine the Effects of ORF3 on Host Cells

(2016) Kailian Xu et al.   Biomed Research International

Molecular Biology and Infection of Hepatitis E Virus

(2016) Yuchen Nan et al.   Frontiers in Microbiology

The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1

(2016) Man He et al.   Scientific Reports

Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses

(2015) Tero Ahola et al.   Biology Direct

The intergenic-junction variant (genotype 2 isolate) of hepatitis E virus restores the CREX ‘stem-loop’ structural integrity, essential for viral life cycle

(2015) Mohammad Khalid Parvez   GENE

The Lysine Residues within the Human Ribosomal Protein S17 Sequence Naturally Inserted into the Viral Nonstructural Protein of a Unique Strain of Hepatitis E Virus Are Important for Enhanced Virus Replication

(2015) Scott P. Kenney et al.   JOURNAL OF VIROLOGY

Hepatitis E virus and neurological injury

(2015) Harry R. Dalton et al.   Nature Reviews Neurology

Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101

(2015) Scott P. Kenney et al.   VIROLOGY

Zoonotic origin of hepatitis E

(2015) Nicole Pavio et al.   Current Opinion in Virology

Identification and Fine Mapping of Nuclear and Nucleolar Localization Signals within the Human Ribosomal Protein S17

(2015) Scott P. Kenney et al.   PLoS One

Consensus proposals for classification of the family Hepeviridae

(2014) D. B. Smith et al.   JOURNAL OF GENERAL VIROLOGY

Hepatitis E virus (HEV) protease: a chymotrypsin-like enzyme that processes both non-structural (pORF1) and capsid (pORF2) protein

(2014) D. Paliwal et al.   JOURNAL OF GENERAL VIROLOGY

Decline in Hepatitis E Virus Antibody Prevalence in the United States From 1988–1994 to 2009–2010

(2014) Eyasu H. Teshale et al.   JOURNAL OF INFECTIOUS DISEASES

Enhancement of Interferon Induction by ORF3 Product of Hepatitis E Virus

(2014) Y. Nan et al.   JOURNAL OF VIROLOGY

Naked Viruses That Aren't Always Naked: Quasi-Enveloped Agents of Acute Hepatitis

(2014) Zongdi Feng et al.   Annual Review of Virology

The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2

(2013) Shigeo Nagashima et al.   ARCHIVES OF VIROLOGY

Virus Budding and the ESCRT Pathway

(2013) Jörg Votteler et al.   Cell Host & Microbe

Hepatitis E Virus Genotype 1 Infection of Swine Kidney Cells In Vitro Is Inhibited at Multiple Levels

(2013) H. T. Nguyen et al.   JOURNAL OF VIROLOGY

A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

(2013) Zongdi Feng et al.   NATURE

Zoonotic and Foodborne Transmission of Hepatitis E Virus

(2013) Xiang-Jin Meng   SEMINARS IN LIVER DISEASE

Molecular Virology of Hepatitis E Virus

(2013) Zulfazal Ahmad et al.   SEMINARS IN LIVER DISEASE

Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus

(2013) Qin Zhao et al.   VETERINARY MICROBIOLOGY

Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity

(2013) Mohammad Khalid Parvez   VIRUS RESEARCH

Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs

(2012) L. Cordoba et al.   JOURNAL OF GENERAL VIROLOGY

The PSAP Motif within the ORF3 Protein of an Avian Strain of the Hepatitis E Virus Is Not Critical for Viral Infectivity In Vivo but Plays a Role in Virus Release

(2012) S. P. Kenney et al.   JOURNAL OF VIROLOGY

Evolution of the Hepatitis E Virus Polyproline Region: Order from Disorder

(2012) Michael A. Purdy   JOURNAL OF VIROLOGY

Herpesvirus Tegument Protein pUL37 Interacts with Dystonin/BPAG1 To Promote Capsid Transport on Microtubules during Egress

(2012) D. Pasdeloup et al.   JOURNAL OF VIROLOGY

The Hepatitis E Virus Polyproline Region Is Involved in Viral Adaptation

(2012) Michael A. Purdy et al.   PLoS One

Suppression of interferon-α signaling by hepatitis E virus

(2011) Chen Dong et al.   HEPATOLOGY

Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions

(2011) S. Nagashima et al.   JOURNAL OF GENERAL VIROLOGY

Mutational Analysis of the Hypervariable Region of Hepatitis E Virus Reveals Its Involvement in the Efficiency of Viral RNA Replication

(2011) R. S. Pudupakam et al.   JOURNAL OF VIROLOGY

The Hepatitis E Virus ORF3 Protein Regulates the Expression of Liver-Specific Genes by Modulating Localization of Hepatocyte Nuclear Factor 4

(2011) Vivek Chandra et al.   PLoS One

Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant

(2011) P. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular virology of hepatitis E virus

(2011) Imran Ahmad et al.   VIRUS RESEARCH

Structure of hepatitis E viral particle

(2011) Yoshio Mori et al.   VIRUS RESEARCH

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hepatitis E Virus (HEV) Strains in Serum Samples Can Replicate Efficiently in Cultured Cells Despite the Coexistence of HEV Antibodies: Characterization of HEV Virions in Blood Circulation

(2010) M. Takahashi et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells

(2010) S. Nagashima et al.   JOURNAL OF GENERAL VIROLOGY

The Nucleotides on the Stem-Loop RNA Structure in the Junction Region of the Hepatitis E Virus Genome Are Critical for Virus Replication

(2010) D. Cao et al.   JOURNAL OF VIROLOGY

Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs

(2010) Alicia R. Feagins et al.   VIRUS RESEARCH

Immunogenicity and efficacy of a bacterially expressed HEV ORF3 peptide, assessed by experimental infection of primates

(2009) Hongxia Ma et al.   ARCHIVES OF VIROLOGY

The hepatitis E virus ORF3 protein stabilizes HIF-1α and enhances HIF-1-mediated transcriptional activity through p300/CBP

(2009) Syed M. Moin et al.   CELLULAR MICROBIOLOGY

ORF3 protein of hepatitis E virus is essential for virion release from infected cells

(2009) K. Yamada et al.   JOURNAL OF GENERAL VIROLOGY

Recent advances in Hepatitis E Virus

(2009) X. J. Meng   JOURNAL OF VIRAL HEPATITIS

The Hepatitis E Virus Open Reading Frame 3 Product Interacts with Microtubules and Interferes with Their Dynamics

(2009) H. Kannan et al.   JOURNAL OF VIROLOGY

Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces

(2008) Masaharu Takahashi et al.   ARCHIVES OF VIROLOGY

The unfoldomics decade: an update on intrinsically disordered proteins

(2008) A Keith Dunker et al.   BMC GENOMICS

The Hepatitis E Virus ORF3 Protein Modulates Epidermal Growth Factor Receptor Trafficking, STAT3 Translocation, and the Acute-Phase Response

(2008) V. Chandra et al.   JOURNAL OF VIROLOGY

Deletions of the Hypervariable Region (HVR) in Open Reading Frame 1 of Hepatitis E Virus Do Not Abolish Virus Infectivity: Evidence for Attenuation of HVR Deletion Mutants In Vivo

(2008) R. S. Pudupakam et al.   JOURNAL OF VIROLOGY