Article
Biochemistry & Molecular Biology
Marta Prygiel, Ewa Mosiej, Karol Wdowiak, Daniel Rabczenko, Aleksandra Anna Zasada
Summary: There is a growing interest in developing new-generation purified antigen vaccines with higher safety profiles. Subunit vaccines have lower immunogenicity and induce weaker and shorter-lasting immune responses compared to whole-cell vaccines.
Article
Immunology
Lise Boey, Eline Bosmans, Liane Braz Ferreira, Nathalie Heyvaert, Melissa Nelen, Lisa Smans, Hanne Tuerlinckx, Mathieu Roelants, Kathleen Claes, Inge Derdelinckx, Wim Janssens, Chantal Mathieu, Johan Van Cleemput, Robin Vos, Isabelle Desombere, Corinne Vandermeulen
Summary: Patients with chronic diseases showed insufficient vaccine protection against diphtheria and pertussis, with factors like vaccination timing and age impacting the antibody levels. Tetanus, however, had higher protection rates among at-risk patients, especially when vaccinated within the last ten years.
Article
Biotechnology & Applied Microbiology
Dandan Liu, Xiaoping Cheng, Shi Wei, Lin Yuan, Changhui Chen, Kaihu Yao
Summary: The study in China revealed the immunity levels against diphtheria, tetanus, and pertussis, showing susceptibility in young infants and adults and low immunity to pertussis across all age groups. This highlights the need to enhance the current vaccination program.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Infectious Diseases
Lindsay Nicholson, Elizabeth Adkins, Mulya Rahma Karyanti, Anna Ong-Lim, Bhaskar Shenoy, Catherine Huoi, Juan C. Vargas-Zambrano
Summary: Outbreaks and rising incidence of diphtheria, tetanus, and pertussis have been observed in Asia among older children. Limited data on the epidemiology of these diseases were reported. Seroprevalence data suggest insufficient immunity to pertussis and diphtheria in the 3-18 years age group in Asia. The findings highlight the need for booster vaccinations to improve immunity in this population.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Inci Aydin, Marcus May, Fabio Pisano, Nontsikelelo Mpofu-Maetzig, Leander Grode, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Hitt Sharma, Harish Rao, Manish Gautam, Sunil Gairola, Umesh Shaligram
Summary: This study evaluated the safety and immunogenicity of a new booster vaccine manufactured by Serum Institute of India Pvt. Ltd (SIIPL Tdap) against tetanus, diphtheria, and pertussis. The results showed that SIIPL Tdap is non-inferior to the comparator Tdap in terms of safety and immunogenicity, with higher antibody concentrations.
Article
Economics
Dan Wu, Rize Jing, Hui Zheng, Kun He, Yixing Li, Wenzhou Yu, Zundong Yin, Hai Fang
Summary: This study evaluated the health and economic impact of DTwP and DTaP vaccination on pertussis prevention and control in China from 1978 to 2017. The results showed that vaccination significantly reduced pertussis cases and deaths, resulting in substantial cost savings and societal benefits.
Article
Immunology
Rita Soares Barbosa Cardona, Lily Yin Weckx, Maria Isabel de Moraes-Pinto, Barbara Cristina Ferreira Ramos, Andreia Regina Augusto dos Santos, Fernanda Garcia Spina, Beatriz Collaco de Araujo, Ralf Clemens, Sue Ann Costa Clemens
Summary: The study reveals that a significant number of healthcare professionals in Brazil are not immune to pertussis. It also highlights the low awareness and coverage of Tdap vaccination among these professionals. The research further demonstrates that Tdap vaccination can increase anti-pertussis toxin antibody levels, which gradually decline over time.
Article
Biochemistry & Molecular Biology
Michal Lipschuetz, Joshua Guedalia, Sarah M. Cohen, Yishai Sompolinsky, Galit Shefer, Eli Melul, Zivanit Ergaz-Shaltiel, Debra Goldman-Wohl, Simcha Yagel, Ronit Calderon-Margalit, Ofer Beharier
Summary: An analysis in Israel found that a third booster dose of the BNT162b2 mRNA vaccine given to mothers before or during pregnancy provides greater protection against COVID-19 hospitalization in infants compared to two doses. This nationwide cohort study investigated the effectiveness of the third maternal dose versus the second dose in preventing infant COVID-19-related hospitalizations. The third dose was associated with a 53% reduced risk of infant hospitalization compared to the second dose.
Article
Immunology
Laura Maria Rivera-Santamaria, Doracelly Hincapie-Palacio, Jesus Ochoa, Felipe Vargas-Restrepo, Marta C. Ospina, Seti Buitrago-Giraldo
Summary: The study showed that vaccination with Tdap during pregnancy can provide protection to both mothers and newborns, with maternal antibodies being effectively transferred to the newborns, indicating the importance of vaccination during pregnancy.
Article
Immunology
Vishal Rathod, Laxmikant Kadam, Manish Gautam, Prabhu Dasu Gumma, Kevin Marke, Cathy Asokanathan, Alex Douglas-Bardsley, Laura Hassell, Sachin Bhandare, Sumit Gupta, Sameer Parekh, Pramod Pujari, Harish Rao, Hitt Sharma, Umesh Shaligram, Sunil Gairola
Summary: This study developed and validated a multiplex immunoassay (MIA) for the simultaneous estimation of IgG antibodies against pertussis toxin, filamentous hemagglutinin, pertactin, diphtheria toxoid, and tetanus toxoid. The MIA was calibrated using WHO reference standards and complied with US FDA, EMA, and ICH M10 guidelines. It showed good agreement with commercial ELISA assays and a positive correlation with toxin neutralization assays for pertussis and diphtheria.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Nino Khetsuriani, Oleksandr Zaika, Liudmyla Slobodianyk, Heather M. Scobie, Gretchen Cooley, Silvia D. Dimitrova, Brock Stewart, Marika Geleishvili, Vusala Allahverdiyeva, Patrick O'Connor, Shahin Huseynov
Summary: The decline in immunization coverage in Ukraine since 2009 has led to concerns about the resurgence of vaccine-preventable diseases such as diphtheria and tetanus. A serosurvey conducted in 2017 among children born between 2006 and 2015 revealed suboptimal immunity against diphtheria and tetanus, particularly in Zakarpattya. The immunization status was found to be inadequate across all sites. Catch-up vaccination and efforts to increase immunization coverage are needed to prevent the resurgence of these diseases in Ukraine.
Article
Immunology
Olga Ticha, Dido Klemm, Lukas Moos, Isabelle Bekeredjian-Ding
Summary: This study aimed to develop a reliable in vitro assay for characterizing the antigen of tetanus vaccines, with the potential to replace in vivo experiments. Results showed that using PBMC from donor samples to detect TT-specific IgG can reveal specific responses after vaccination.
Article
Immunology
Ikram Abdi, Heather Gidding, Robert Neil Leong, Hannah C. Moore, Holly Seale, Robert Menzies
Summary: This study found that on-time vaccination coverage of diphtheria-tetanus-pertussis dose 3 (DTP3) differed by mother's region of birth in Australia. Different regions showed varying levels of coverage, with lower rates in North America and Oceania, and higher rates in South-East Asia and Southern Asia.
Article
Immunology
Nicola Veronese, Giusy Vassallo, Maria Armata, Laura Cilona, Salvatore Casalicchio, Roberta Masnata, Claudio Costantino, Francesco Vitale, Giovanni Maurizio Giammanco, Stefania Maggi, Shaun Sabico, Nasser M. Al-Daghri, Ligia J. Dominguez, Mario Barbagallo
Summary: Influenza, herpes zoster, pneumococcal, and pertussis infections may increase morbidity and mortality in older people. Vaccination against these pathogens is effective, but coverage remains low. Frailty seems to be associated with vaccination status, particularly anti-pneumococcus, but more research is needed for confirmation.
Article
Immunology
Nasamon Wanlapakorn, Napa Pruetarat, Nasiri Sarawanangkoor, Kanchana Phanphanit, Donchida Srimuan, Thaksaporn Thatsanathorn, Thanunrat Thongmee, Nawarat Posuwan, Yong Poovorawan
Summary: This study compared the immunogenicity of the Shan-5 vaccine with the optional Quinvaxem and Infanrix-hexa vaccines. The results showed that the immunogenicity of the Shan-5 vaccine was similar to the hexavalent vaccine, but higher than the Quinvaxem vaccine.
Article
Chemistry, Medicinal
Sietske Kooijman, Hilde Vrieling, Lisa Verhagen, Justin de Ridder, Alex de Haan, Elly van Riet, Albert J. R. Heck, Gideon F. A. Kersten, Jeroen L. A. Pennings, Bernard Metz, Hugo D. Meiring
Summary: This study compares the immune response induced by aluminum hydroxide and aluminum phosphate adjuvants in vitro and in vivo, revealing differences in their molecular mechanisms and regulation of innate immune processes.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Substance Abuse
Jeroen L. A. Pennings, Anne Havermans, Charlotte G. G. M. Pauwels, Erna J. Z. Krusemann, Wouter F. Visser, Reinskje Talhout
Summary: The presence of nicotine salt-containing e-liquids in the Netherlands market has increased significantly in recent years. Nicotine salts, due to their characteristics, make these e-liquids more addictive and attractive, particularly to young and inexperienced users. Policymakers are advised to regulate products containing nicotine salts.
Article
Substance Abuse
Jeroen L. A. Pennings, Geoffrey Ferris Wayne, Walther N. M. Klerx, Charlotte G. G. M. Pauwels, Reinskje Talhout
Summary: This study explores the impact of tobacco blend and design characteristics on the sensory experience of cigarette consumers. The findings suggest that while some variations in design are noticeable to consumers, many products on the market are not discernibly different, indicating that brand diversity may serve non-sensory purposes such as marketing.
Article
Food Science & Technology
Jeroen L. A. Pennings, Eric Abachin, Raphael Esson, Hennie Hodemaekers, Antoine Francotte, Jean-Baptiste Claude, Celine Vanhee, Sylvie Uhlrich, Rob J. Vandebriel
Summary: The study used RNA sequencing to identify RNA signatures related to consistent TeNT production by Clostridium tetani under standard and non-standard culture conditions. Time-dependent differentially expressed genes (DEGs) were identified, with the tetX gene showing potential as a transcriptional biomarker for monitoring TeNT production. Non-standard culture conditions led to different gene expression responses, highlighting the importance of batch-to-batch consistency testing in tetanus vaccine manufacturing.
Article
Biochemistry & Molecular Biology
Rob J. Vandebriel, Sylvie Remy, Jolanda P. Vermeulen, Evelien G. E. Hurkmans, Kirsten Kevenaar, Neus G. Bastus, Beatriz Pelaz, Mahmoud G. Soliman, Victor F. Puntes, Wolfgang J. Parak, Jeroen L. A. Pennings, Inge Nelissen
Summary: The study compared the effects of gold nanoparticles of different shapes on NLRP3 inflammasome activation and found that nanorods can activate the NLRP3 inflammasome, while nanostars and nanospheres cannot. Additionally, gold nanorod-induced NLRP3 inflammasome activation was accompanied by downregulated gene sets related to sterol/cholesterol biosynthesis, oxidative phosphorylation, and purinergic receptor signaling, with notable downregulation of Paraoxonase-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Substance Abuse
Ingrid M. E. Bakker-'t Hart, Frank Bakker, Jeroen L. A. Pennings, Naomi Weibolt, Selma Eising, Reinskje Talhout
Summary: This study examines the commonly used flavors and flavorings in waterpipe tobacco and related products, and presents a waterpipe tobacco flavor wheel for experts' reference. The analysis reveals that the majority of waterpipe tobacco products are flavored, with fruit flavors being the most prevalent. Herbal molasses and steam stones contain similar levels of flavorings, with lower levels compared to waterpipe tobacco. The flavorings in waterpipe products are mainly fruity and sweet, often combined with menthol/mint flavorings. Banning flavorings in all waterpipe products could be an effective strategy to reduce waterpipe smoking among youth.
Correction
Immunology
Coen A. L. Stalpers, Irene A. Retmana, Jeroen L. A. Pennings, Rob J. Vandebriel, Coenraad F. M. Hendriksen, Arnoud M. Akkermans, Marcel H. N. Hoefnagel
Article
Reproductive Biology
Laura M. M. Samrani, Jeroen L. A. Pennings, Nina Hallmark, Remi Bars, Helen Tinwell, Marc Pallardy, Aldert H. Piersma
Summary: The study investigates the effect of exposure duration on gene expression changes in the all-trans retinoic acid (ATRA) signaling pathway in zebrafish embryotoxicity test (ZET). It is found that the highest magnitudes of gene expression regulation occur after 2-24 hrs exposure, with the optimal response at 4 hrs. Early assessment of gene expression regulation after exposure onset in ZET could be optimal for predicting developmental toxicity.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Substance Abuse
Jeroen L. A. Pennings, Anne Havermans, Erna J. Z. Krusemann, Dion Zijtveld, Eva H. W. Huiberts, Peter M. J. Bos, Erna Schenk, Wouter F. Visser, Ingrid M. EBakker-'t Hart, Yvonne C. M. Staal, Reinskje Talhout
Summary: The Dutch government plans to only allow tobacco flavors in e-liquids to discourage e-cigarette use among youth. Researchers have compiled a restrictive list of 16 tobacco flavorings to implement this policy.
Review
Chemistry, Medicinal
Christina H. J. Veltman, Jeroen L. A. Pennings, Bob van de Water, Mirjam Luijten
Summary: Nongenotoxic (NGTX) carcinogens induce cancer through mechanisms other than direct DNA damage, primarily involving the induction of oxidative stress leading to regenerative proliferation. However, current carcinogenicity assessment methods mainly focus on genetic toxicity, which may overlook NGTX carcinogens. To improve the predictivity of carcinogenicity assessment, a mechanism-based approach such as the adverse outcome pathway (AOP) network for chemically induced oxidative stress leading to (NGTX) carcinogenesis is proposed. This AOP network considers the role of oxidative stress in cancer development and explores the mechanisms and biological effects of chemical-induced oxidative damage. Developing AOP networks relevant to human carcinogenesis will facilitate a transition to a mechanism-based, human-relevant carcinogenicity assessment with reduced reliance on laboratory animals.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Neurosciences
Faycal Guedj, Elise Kane, Lauren A. Bishop, Jeroen L. A. Pennings, Yann Herault, Diana W. Bianchi
Summary: The effectiveness of the Ts65Dn mouse model in improving neurocognition in Down syndrome has not been successfully translated to humans. The Ts66Yah mouse model, which carries an extra chromosome and identical segmental trisomy as Ts65Dn, was used to investigate the underlying factors.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biochemical Research Methods
Irene A. Retmana, Nancy H. C. Loos, Alfred H. Schinkel, Jos H. Beijnen, Rolf W. Sparidans
Summary: We developed and validated a liquid chromatography-tandem mass spectrometry assay to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue-related matrices. The assay demonstrated a linear calibration range, good precision, and accuracy across various matrices. This method was successfully applied to determine the pharmacokinetic profile and tissue distribution of adagrasib in wild-type mice.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Substance Abuse
Charlotte G. G. M. Pauwels, Wouter F. Visser, Jeroen L. A. Pennings, Ernesto P. Baloe, Arnout P. T. Hartendorp, Loes van Tiel, Mirjam van Mourik, Wim Vaessen, Sanne Boesveldt, Reinskje Talhout
Summary: This study aimed to determine whether nicotine salts increase sensory appeal at lower concentrations and compared the inhalation intensity of both types of e-liquids. The results showed that nicotine salts did not significantly affect sensory appeal, harshness, and puffing intensity compared to free-based nicotine.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Chemistry, Analytical
Irene A. Retmana, Nancy H. C. Loos, Alfred H. Schinkel, Jos H. Beijnen, Rolf W. Sparidans
Summary: We have developed and validated a bioanalytical assay using liquid chromatography tandem mass spectrometry to measure the KRASG12C inhibitor sotorasib and its major metabolite M24 in mouse matrices. Sotorasib had limited stability in mouse plasma, while M24 remained stable for a longer period. This method can be applied to measure sotorasib and M24 in different mouse matrices.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Substance Abuse
Jeroen L. A. Pennings, Charlotte G. G. M. Pauwels, Erna Schenk, Reinskje Talhout
Summary: Cigarillos have emerged as a substitute for flavored cigarettes, which are prohibited in the European Union, and they are also cheaper. To gain a better understanding of the cigarillo market, we analyzed product data from manufacturers via the EU-CEG system.
TOBACCO INDUCED DISEASES
(2023)