Multiple sclerosis: doubling down on MHC

HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

(2020) Jian Wang et al.   CELL

Attenuated immune control of Epstein Barr virus in humanized mice is associated with the multiple sclerosis risk factor HLA‐DR15

(2020) Hana Zdimerova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

(2020) Christian Lundtoft et al.   PLoS Genetics

The HLA diversity of the Anthony Nolan register

(2020) Gayle Leen et al.   HLA

Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk

(2019) Katarina Tengvall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15

(2019) Lukas Simon Enz et al.   Neurology-Neuroimmunology & Neuroinflammation

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

(2018) Ivan Jelcic et al.   CELL

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

(2017) Joshua D. Ooi et al.   NATURE

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Leukocyte Antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 Present Complementary Peptide Repertoires

(2017) Erika Margaret Scholz et al.   Frontiers in Immunology

Class II HLA interactions modulate genetic risk for multiple sclerosis

(2015) Loukas Moutsianas et al.   NATURE GENETICS

Oligodendrocyte death results in immune-mediated CNS demyelination

(2015) Maria Traka et al.   NATURE NEUROSCIENCE

Uncoupling the Roles of HLA-DRB1 and HLA-DRB5 Genes in Multiple Sclerosis

(2014) S. J. Caillier et al.   JOURNAL OF IMMUNOLOGY

JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants

(2014) Emilie Sundqvist et al.   PLoS Pathogens

HLA-DR15-derived self-peptides are involved in increased autologous T cell proliferation in multiple sclerosis

(2013) Malte Mohme et al.   BRAIN

Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis

(2012) J. A. Quandt et al.   JOURNAL OF IMMUNOLOGY

TCR Bias and HLA Cross-Restriction Are Strategies of Human Brain-Infiltrating JC Virus-Specific CD4+ T Cells during Viral Infection

(2012) S. Yousef et al.   JOURNAL OF IMMUNOLOGY

HL-A Antigens and Multiple Sclerosis

(2010) J. BERTRAMS et al.   TISSUE ANTIGENS

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

(2009) M. R. Lincoln et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

(2008) Jorge R. Oksenberg et al.   NATURE REVIEWS GENETICS