Article
Oncology
Shunjin Ryu, Keigo Hara, Atsuko Okamoto, Takahiro Kitagawa, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: This study demonstrates the utility of NIRFUC for ureteral navigation during laparoscopic surgery for stage T4 colorectal cancer. Patients in the T4FUN + group had longer operative times but higher laparoscopic ratios, lower blood loss volumes, and tended to have lower ureteral injury rates compared to the T4FUN- group.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Surgery
Shunjin Ryu, Keigo Hara, Takahiro Kitagawa, Atsuko Okamoto, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: In laparoscopic lateral lymph node dissection (LLND) for lower rectal cancer, fluorescence navigation using near-infrared ray fluorescent ureteral catheter (NIRFUC) and indocyanine green (ICG) was found to be effective in clearly identifying the ureter, detecting branch forms from the internal iliac artery, and increasing surgical safety without causing ureter or vessel injuries.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Oncology
Shunjin Ryu, Keisuke Goto, Yuta Imaizumi, Yukio Nakabayashi
Summary: In this study, the AI model Eureka was used as an educational tool for surgeons during laparoscopic colorectal surgery. Total mesorectal excision (TME) with nerve preservation was safely performed, and no postoperative complications occurred. Automatic segmentation and highlighting of loose connective tissue (LCT) and lumbar splanchnic, hypogastric, and pelvic visceral nerves (S3, S4) were achieved in real time.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Chu Luan Nguyen, Michael Zhou, Neshanth Easwaralingam, Jue Li Seah, Farhad Azimi, Cindy Mak, Carlo Pulitano, Sanjay Warrier
Summary: This study compared the clinical efficacy and costs of using ICG-RI and BD-RI as tracers for dual sentinel lymph node biopsy, and found that ICG-RI is an effective and safe alternative, albeit at higher costs.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Po-Li Wei, Yan-Jiun Huang, Weu Wang, Yu-Min Huang
Summary: This study compared the effects of robotic reduced-port surgery and conventional laparoscopic surgery for left-sided colorectal cancer. The results showed that the two groups were similar in most outcome measures except for the distal resection margin, which was significantly longer in the laparoscopic group. The between-group differences in reoperation, incisional hernia development, and overall and progression-free survival were not significant, but the total hospital cost was significantly higher in the robotic group. Therefore, robotic reduced-port surgery for left-sided colorectal cancer is safe and effective but more expensive with no additional benefit compared with the conventional laparoscopic approach. This observation warrants further evaluation.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Gastroenterology & Hepatology
Elodie Zocola, Jeremy Meyer, Niki Christou, Emilie Liot, Christian Toso, Nicolas Christian Buchs, Frederic Ris
Summary: Near-infrared fluorescence (NIRF) is a valuable technique in colorectal surgery, aiding surgeons in visualizing and assessing bowel vascularization, identifying lymph nodes, and ureters.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Surgery
Tsutomu Takenami, Shingo Tsujinaka, Yasuyuki Miyakura, Nao Kakizawa, Ryo Maemoto, Erika Machida, Yuuri Hatsuzawa, Rei Takahashi, Yasuaki Kimura, Sawako Tamaki, Hideki Ishikawa, Toshiki Rikiyama
Summary: This study evaluated the impact of sarcopenia on short- and long-term outcomes for laparoscopic colorectal cancer surgery. The results showed that sarcopenic patients may have shorter operative times and a lower incidence of surgical site infections, but they also have an increased risk of severe postoperative complications and readmission. Additionally, sarcopenic patients have a significantly worse 3-year overall survival rate compared to non-sarcopenic patients.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Hematology
Cecilia Becattini, Ugo Pace, Felice Pirozzi, Annibale Donini, Giampiero Avruscio, Fabio Rondelli, Michela Boncompagni, Damiano Chiari, Marco De Prizio, Adriana Visona, Raffaele De Luca, Francesco Guerra, Andrea Muratore, Giuseppe Portale, Marco Milone, Giampaolo Castagnoli, Marc Righini, Jacopo Martellucci, Roberto Persiani, Stefania Frasson, Francesco Dentali, Paolo Delrio, Mauro Campanini, Gualberto Gussoni, Maria Cristina Vedovati, Giancarlo Agnelli
Summary: Rivaroxaban is more effective than placebo in extended prevention of VTE after laparoscopic surgery for colorectal cancer without increasing the risk of major bleeding.
Article
Health Care Sciences & Services
Jiyoun Kim, Yoon Jang, Su Hyeon Choi, Yong Wook Jung, Mi-La Kim, Bo Seong Yun, Seok Ju Seong, Hye Sun Jun
Summary: This study demonstrates the feasibility of ureteral navigation using intraoperative indocyanine green (ICG) and near-infrared fluorescence (NIRF) imaging during complex gynecologic surgery. All patients had successful identification of ureteral pathways using ICG-NIRF imaging, with no cases of ureteral injury or transfusion. This technique improves the safety and simplicity of the surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Analytical
Yaxue Dai, Yongjia Tang, Wenjing Huang, Yue Zhao, Xin Gao, Yueqing Gu
Summary: This study designed novel EpCAM-targeting peptides YQ-S for precise detection of breast cancer. YQ-S2 showed greater binding affinity and ideal biosafety profile, and was chosen to represent YQ-S. By linking with a near-infrared fluorescent dye, the EpCAM-targeting probe YQ-S2-MPA was developed for real-time imaging and fluorescence-guided resection of breast cancer tumors. In vivo experiments showed higher tumor uptake of YQ-S2-MPA compared to SNF-MPA, and successful detection of metastatic lesions. YQ-S2-MPA also performed excellently in surgical navigation studies in preclinical models.
Article
Oncology
Shunjin Ryu, Takahiro Kitagawa, Keisuke Goto, Atsuko Okamoto, Rui Marukuchi, Keigo Hara, Ryusuke Ito, Yukio Nakabayashi
Summary: This study aimed to investigate the feasibility of using mixed reality-based holograms for intraoperative navigation in colorectal surgery. The results showed that viewing holograms improved surgical understanding and allowed for safe procedures. Holographic guidance is a novel surgical concept that has the potential to reduce the mental demand on surgeons.
ANTICANCER RESEARCH
(2022)
Article
Surgery
Matthew Albert, Leticia Delgado-Herrera, Jennifer Paruch, Pauline Gerritsen-van Schieveen, Tomoyoshi Kishimoto, Shin Takusagawa, Na Cai, John Fengler, Jeffrey Raizer
Summary: In this study, researchers successfully achieved ureter visualization using a near-infrared fluorescence imaging technique, providing assistance for laparoscopic colorectal surgery. The drug pudexacianinium showed good efficacy at doses of 1.0 and 3.0 mg, and its safety and tolerability were confirmed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Takashi Harino, Shingo Noura, Atsushi Hamabe, Takayuki Ogino, Hiroshi Takeyama, Yozo Suzuki, Tsukasa Tanida, Naohiro Tomita, Keizo Dono
Summary: Discontinuation of aspirin in laparoscopic colorectal cancer surgery increases the risk of severe thrombotic complications. Although bleeding complications significantly increased in the group continuing aspirin, thrombotic complications were significantly more frequent in the group discontinuing aspirin.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Wojciech Polom, Marcin Migaczewski, Jaroslaw Skokowski, Maciej Swierblewski, Tomasz Cwalinski, Leszek Kalinowski, Michal Pedziwiatr, Marcin Matuszewski, Karol Polom
Summary: This study demonstrates the potential of using two different fluorophores in colorectal surgery. Visualisation with fluorophores aids in intraoperative localization and angiography, optimizing surgical outcomes. The use of two separate dyes may represent a direction for the development of image-guided surgery, showcasing advancements in optical technologies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Surgery
Trevor M. Yeung
Summary: Fluorescence imaging is a potentially useful tool for colorectal surgery, with applications in assessing tissue perfusion, tumor evaluation, lymphatic drainage, and urinary tract identification. While nonspecific fluorescent dyes like indocyanine green and methylene blue are commonly used, the development of specific fluorescently labeled molecular markers holds great promise for enhancing the utility of fluorescence imaging during surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Oncology
Shunjin Ryu, Kota Ishida, Atsuko Okamoto, Keigo Nakashima, Keigo Hara, Ryusuke Ito, Yukio Nakabayashi
SURGICAL ONCOLOGY-OXFORD
(2020)
Article
Surgery
Keigo Nakashima, Shunjin Ryu, Atsuko Okamoto, Keigo Hara, Kota Ishida, Ryusuke Ito, Yukio Nakabayashi
Summary: This study aimed to comprehensively evaluate intestinal blood flow using normal light and indocyanine green (ICG) fluorescence imaging, and assess the validity of the chosen surgical plan. The results showed that ICG fluorescence imaging is useful in laparoscopic surgery for treating strangulated bowel obstruction.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Shunjin Ryu, Keigo Hara, Takahiro Kitagawa, Atsuko Okamoto, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: In laparoscopic lateral lymph node dissection (LLND) for lower rectal cancer, fluorescence navigation using near-infrared ray fluorescent ureteral catheter (NIRFUC) and indocyanine green (ICG) was found to be effective in clearly identifying the ureter, detecting branch forms from the internal iliac artery, and increasing surgical safety without causing ureter or vessel injuries.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Keigo Hara, Shunjin Ryu, Atsuko Okamoto, Takahiro Kitagawa, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: The use of fluorescent clip marking (FCM) in complete laparoscopic distal gastrectomy can shorten gastric resection time and potentially reduce operative time. FCM is feasible and safe, serving as a tumor-marking agent to determine accurate surgical resection lines.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Shunjin Ryu, Keigo Hara, Keisuke Goto, Atsuko Okamoto, Takahiro Kitagawa, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: In this study, the effectiveness of ICG fluorescence angiography (ICG-FA) as an alternative to palpation in surgery for strangulated bowel obstruction was investigated. The results demonstrated that ICG-FA is useful as a substitute for palpation during laparoscopic surgery and has the potential to improve surgical outcomes.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Oncology
Shunjin Ryu, Keigo Hara, Atsuko Okamoto, Takahiro Kitagawa, Rui Marukuchi, Ryusuke Ito, Yukio Nakabayashi
Summary: This study demonstrates the utility of NIRFUC for ureteral navigation during laparoscopic surgery for stage T4 colorectal cancer. Patients in the T4FUN + group had longer operative times but higher laparoscopic ratios, lower blood loss volumes, and tended to have lower ureteral injury rates compared to the T4FUN- group.
SURGICAL ONCOLOGY-OXFORD
(2022)
Letter
Gastroenterology & Hepatology
Shunjin Ryu, Takahiro Kitagawa, Keisuke Goto, Junichi Shimada, Ryusuke Ito, Yukio Nakabayashi
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Shunjin Ryu, Keisuke Goto, Takahiro Kitagawa, Junichi Shimada, Ryusuke Ito, Yukio Nakabayashi
COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Shunjin Ryu, Keisuke Goto, Takahiro Kitagawa, Takehiro Kobayashi, Junichi Shimada, Ryusuke Ito, Yukio Nakabayashi
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Letter
Gastroenterology & Hepatology
Shunjin Ryu, Keisuke Goto, Yuta Imaizumi, Junichi Shimada, Ryusuke Ito, Yukio Nakabayashi
COLORECTAL DISEASE
(2023)
Article
Oncology
Shunjin Ryu, Keisuke Goto, Yuta Imaizumi, Yukio Nakabayashi
Summary: In this study, the AI model Eureka was used as an educational tool for surgeons during laparoscopic colorectal surgery. Total mesorectal excision (TME) with nerve preservation was safely performed, and no postoperative complications occurred. Automatic segmentation and highlighting of loose connective tissue (LCT) and lumbar splanchnic, hypogastric, and pelvic visceral nerves (S3, S4) were achieved in real time.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Shunjin Ryu, Masashi Yoshida, Ohdaira Hironori, Nobuhiro Tsutsui, Norihiko Suzuki, Eisaku Ito, Keigo Nakajima, Satoru Yanagisawa, Masaki Kitajima, Yutaka Suzuki
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2016)
Article
Medicine, General & Internal
Shunjin Ryu, Masashi Yoshida, Hironori Ohdaira, Nobuhiro Tsutsui, Norihiko Suzuki, Eisaku Ito, Keigo Nakajima, Satoru Yanagisawa, Masaki Kitajima, Yutaka Suzuki
ANNALS OF MEDICINE AND SURGERY
(2016)