Article
Biochemistry & Molecular Biology
Loretta Ferrera, Raffaella Barbieri, Cristiana Picco, Paolo Zuccolini, Alessia Remigante, Sara Bertelli, Maria Rita Fumagalli, Giovanni Zifarelli, Caterina A. M. La Porta, Paola Gavazzo, Michael Pusch
Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Eunus S. Ali, Grigori Y. Rychkov, Greg J. Barritt
Summary: TRPM2 channels allow for the movement of Ca2+ and Na+ across the plasma membrane and release of Ca2+ and Zn2+ from lysosomes. Activation of TRPM2 by ROS plays a key role in cell injury and death, particularly in chronic liver diseases and acute liver injury. Inhibiting TRPM2 using compounds like curcumin shows promise in reducing ROS-induced liver cell damage.
Article
Biochemistry & Molecular Biology
Antonio Willame da Silva Alves, Bruno Lopes Sousa, Luiz Francisco Wemmenson Goncalves Moura, Emanuela de Lima Reboucas, Marnielle Rodrigues Coutinho, Antonio Wlisses Silva, Renata Pinheiro Chaves, Romulo Farias Carneiro, Eduardo Henrique Salviano Bezerra, Maria Izabel Florindo Guedes, Eridan Orlando Pereira Tramontina Florean, Celso Shiniti Nagano, Alexandre Holanda Sampaio, Bruno Anderson Matias Rocha
Summary: Inflammation and oxidative stress are processes associated with various diseases. This study investigates the potential of CiL-1, a compound found in seaweed, as an anti-nociceptive and anti-inflammatory agent. Results show that CiL-1 effectively reduces pain and inflammation in adult zebrafish. Additionally, CiL-1 reduces the levels of reactive oxygen species (ROS) in the brain and liver. In silico analyses suggest that CiL-1 interacts with specific ligands and may modulate the TRPA1 channel, explaining its anti-inflammatory effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Katharina E. M. Hellenthal, Laura Brabenec, Eric R. Gross, Nana-Maria Wagner
Summary: The transient receptor potential (TRP) cation channel superfamily consists of more than 50 channels playing crucial roles in physiological processes. Aldehydes can activate TRP channels, triggering a cellular cascade that may lead to disease pathophysiology. Studies have shown that aldehyde dehydrogenase 2 protects against aldehyde toxicity by clearing toxic aldehydes.
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Biochemistry & Molecular Biology
Inan Kaya, Serpil Dag, Muge Mavioglu Kaya, Erdi Anil Tanriverdi, Hatice Beseren, Gizem Asasin
Summary: This study evaluated the effects of pomegranate fruit extract (PFE) on mice with induced colorectal cancer (CRC) and found that it can modulate the expression of TRPA1 and TRPM2 channels, promote apoptosis, and inhibit inflammatory response by reducing oxidative stress.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Cell Biology
Akito Nakao, Yoshihiro Matsunaga, Katsumi Hayashida, Nobuaki Takahashi
Summary: Psychiatric disorders are believed to be caused by complex and diverse factors, with oxidative stress playing a crucial role in the pathogenesis of major disorders such as bipolar disorder, depression, anxiety disorder, and schizophrenia. Calcium channels are essential for neuronal functions, and the investigation of redox-sensitive TRP channels could lead to the development of new therapeutic strategies for psychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.