Article
Food Science & Technology
Prasenjit Manna, Saikat Dewanjee, Swarnalata Joardar, Pratik Chakraborty, Hiranmoy Bhattacharya, Shrestha Bhanja, Chiranjib Bhattacharyya, Manas Bhowmik, Shovonlal Bhowmick, Achintya Saha, Joydeep Das, Parames C. Sil
Summary: This study revealed that CA has a protective effect against Dox-induced cardiotoxicity by suppressing oxidative stress and interfering with pathological signaling events. CA can potentially be used as an effective agent to alleviate Dox-induced cardiotoxicity in the future.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bin Ye, Wenchao Ling, Yinhua Wang, Amit Jaisi, Opeyemi Joshua Olatunji
Summary: This study evaluated the protective properties of chrysin (Chy) against cyclophosphamide (CyC)-induced cardiotoxicity in rats. The results showed that chrysin can inhibit CyC-induced cardiotoxicity and restore the altered biochemical and histopathological features of the heart.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Plant Sciences
Qianqian Jiang, Xu Chen, Xue Tian, Jingmei Zhang, Siming Xue, Yanyan Jiang, Tiantian Liu, Xiaoping Wang, Qianbin Sun, Yiqin Hong, Chun Li, Dongqing Guo, Yong Wang, Qiyan Wang
Summary: This study demonstrated that Tanshinone I (Tan I) can protect against Doxorubicin-induced cardiotoxicity (DIC) by reducing oxidative stress and maintaining mitochondrial function. This protective effect is mediated by the activation of the nuclear erythroid factor 2-related factor 2 (Nrf2) pathway.
Article
Environmental Sciences
Yi Mu, Bangwei Che, Kaifa Tang, Wenjun Zhang, Shenghan Xu, Wei Li, Jun He, Miao Liu, Peng Chen, Siwen Zhong, Guangyu Li
Summary: This study explored the protective effect of Dendrobium officinale polysaccharides (DOPs) on reproductive oxidative stress injury in male mice and its mechanism. The results showed that DOPs effectively reduced the oxidative stress injury of testicular tissue and improved sperm quality and hormone levels. The protective effect of DOPs was mediated by reducing oxidative stress levels, improving the hormone environment in testes, and regulating the expression of specific genes in Sertoli cells and spermatogenic cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Alessio Filippo Peritore, Gianluca Antonio Franco, Francesco Molinari, Alessia Arangia, Livia Interdonato, Ylenia Marino, Salvatore Cuzzocrea, Enrico Gugliandolo, Domenico Britti, Rosalia Crupi
Summary: This study revealed that chronic exposure to Vinclozolin can cause myocardial damage, cardiovascular dysfunction, and detrimental effects on cardiac enzymes and gene expression.
Article
Biochemistry & Molecular Biology
Roberta Fusco, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Roberto Crea, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola, Vittorio Calabrese
Summary: The study demonstrates that Hidrox(R) protects the testes from cyclophosphamide-induced damage by modulating physiological antioxidant defenses.
Review
Neurosciences
Hayate Javed, Nagoor Meeran Mohamed Fizur, Niraj Kumar Jha, Ghulam Md. Ashraf, Shreesh Ojha
Summary: Phytochemicals, especially those from spices, have potential as drug candidates for neurodegenerative diseases due to their antioxidant properties. Carvacrol, a phenolic monoterpenoid, has diverse pharmacological effects and has shown potential in treating Alzheimer's disease and Parkinson's disease by reducing oxidative stress and inflammation.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Fatih Mehmet Kandemir, Cuneyt Caglayan, Ekrem Darendelioglu, Sefa Kucukler, Ebubekir Izol, Ozge Kandemir
Summary: Carvacrol (CRV) has been shown to modulate cadmium (Cd)-induced toxic effects on liver and kidney tissues by enhancing antioxidant enzymes' activities and reversing changes in inflammatory biomarkers and apoptotic genes. Additionally, CRV treatment reduced Cd content and increased levels of essential minerals in tissues, suggesting it as a promising strategy to protect against Cd-induced oxidative damage, inflammation, and apoptosis.
Article
Biochemistry & Molecular Biology
Fatemeh Amin, Arghavan Memarzia, Hamideh Kazemi Rad, Farzaneh Shakeri, Mohammad Hossein Boskabady
Summary: Carvacrol and pioglitazone improved systemic oxidative stress and inflammation caused by inhaled paraquat. Additionally, the treatment with C-L+Pio-L showed significantly better effects compared to each one alone.
Review
Biochemistry & Molecular Biology
Chun-Yan Kong, Zhen Guo, Peng Song, Xin Zhang, Yu-Pei Yuan, Teng Teng, Ling Yan, Qi-Zhu Tang
Summary: This review provides a comprehensive overview of the mechanisms underlying the oxidative stress and cell death pathways induced by doxorubicin, which are the major factors responsible for the acute cardiotoxicity. The authors aim to offer new insights for researchers to discover potential therapeutic strategies to prevent or reverse doxorubicin-induced cardiotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Gabriel Mendez-Valdes, Francisca Gomez-Hevia, Maria Chiara Bragato, Jose Lillo-Moya, Catalina Rojas-Sole, Luciano Saso, Ramon Rodrigo
Summary: Breast cancer is the most common malignant neoplastic disease in women, and its treatment depends on patient and tumor characteristics. The overexpression of the HER2 receptor, found in 15-25% of tumors, is associated with aggressive behavior and poor prognosis. Trastuzumab, a monoclonal antibody used as targeted therapy against HER2 receptor overexpression, has a major concern of cardiotoxicity. This review aims to explore the use of antioxidants as adjuvant therapy to prevent trastuzumab-induced cardiac toxicity and improve its safety profile.
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Article
Food Science & Technology
Jan Homolak, Ana Babic Perhoc, Ana Knezovic, Ivan Kodvanj, Davor Virag, Jelena Osmanovic Barilar, Peter Riederer, Melita Salkovic-Petrisic
Summary: Recent research suggests that galactose can maintain cellular function during starvation and prevent/alleviate cognitive deficits in Alzheimer's disease. Acute oral administration of galactose in rats leads to a mild pro-oxidative shift and increased tissue reductive capacity in the hippocampus, potentially through stimulation of endogenous antioxidant systems to detoxify ROS.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jianya Xu, Huafeng Fang, Ying Chong, Lili Lin, Tong Xie, Jianjian Ji, Cunsi Shen, Chen Shi, Jinjun Shan
Summary: This study aimed to examine the teratogenicity of Cyclophosphamide (CP) on pregnant rats. It was found that CP treatment led to the accumulation of oxidized lipids in the amniotic fluid and a decrease in certain metabolites. This suggests that CP may exert toxic effects on pregnant rats through oxidative stress.
Article
Environmental Sciences
Qiang Luo, Shuqiong Tang, Xiaoping Xiao, You Wei, Bo Cheng, Yong Huang, Keyuan Zhong, Guiyou Tian, Huiqiang Lu
Summary: In this study, the toxicity of benomyl to zebrafish was evaluated, showing high toxicity and inducing oxidative stress and apoptosis. These findings provide important insights into the safe use of benomyl.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Senanur Can, Songul Cetik Yildiz, Cumali Keskin, Varol Sahinturk, Mustafa Cengiz, Sila Appak Baskoy, Adnan Ayhanci, Gulsema Akinci
Summary: This study aims to investigate the protective effects of Hypericum triquetrifolium Turra on testes injury induced by cyclophosphamide. The results suggest that Hypericum triquetrifolium Turra has anti-oxidative and anti-apoptotic properties, which can help improve cyclophosphamide-induced testicular injury.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Orthopedics
Nusret Kose, Zeynel M. Asfuroglu, Aydan Kose, Varol Sahinturk, Mevlut Gurbuz, Aydin Dogan
Summary: Experimental study demonstrates that silver ion-doped calcium phosphate-based bone graft substitution can stimulate bone growth, combat infection, and effectively treat chronic osteomyelitis in an animal model.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Ezgi Kar, Ozkan Alatas, Varol Sahinturk, Semih oz
Summary: The study investigated the effects of MET and FGF21 on inflammation due to LPS induced endotoxemia, revealing that MET exhibited a partially protective effect against inflammation and may increase the production of FGF21 in the liver.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fatih Kar, Sedat Kacar, Ceyhan Hacioglu, Gungor Kanbak, Varol Sahinturk
Summary: This study aimed to investigate the effects of Con A on C6 glioblastoma cells, revealing that Con A triggers oxidative damage, inflammation, and apoptosis in a dose-dependent manner, while also disrupting the thiol/disulfide balance within the cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Oncology
Ceyhan Hacioglu, Fatih Kar, Sedat Kacar, Varol Sahinturk, Gungor Kanbak
Summary: Bexarotene treatment showed concentration- and time-dependent anti-proliferative effects on C6 glioma cells by modulating apoptosis profile, DNA damage, reactive oxygen species production, and reducing total antioxidant levels through the inhibition of NF-kappa B by enhancing PPAR gamma expression.
Article
Pharmacology & Pharmacy
Nuriye Ezgi Bektur Aykanat, Erhan Sahin, Sedat Kacar, Ridvan Bagci, Serife Karakaya, Dilek Burukoglu Donmez, Varol Sahinturk
Summary: Our study demonstrated that increased activation of ATF-6, IRE-1, and TRPC1 lead to hypertrophy in hyperthyroidism, which is due to the imbalance of Ca2+ ions.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sedat Kacar, Varol Sahinturk, Ozlem Tomsuk, Hatice M. Kutlu
Summary: Acrylamide has a damaging effect on C6 glioblastoma cells, while thymoquinone and quercetin pretreatments have a protective effect against acrylamide-induced damage in C6 cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Sedat Kacar, Ediz Sariisik, Varol Sahinturk
Summary: High blood levels of beta-carotene and increased intake in the diets are inversely proportional to incidence of many cancer types. The present study found that beta-carotene can inhibit the survival of malignant pleural mesothelioma cells (SPC212), induce cell apoptosis, and increase oxidative stress.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Songul Cetik Yildiz, Cemil Demir, Adnan Ayhanci
Summary: The study investigated the effects of kefir on wound healing in a 2nd-degree mouse burn model infected with e.coli, s.aureus, and p.aeruginosa in vitro. The macroscopic changes in kefir-applied scar tissue, as well as wound depth and width, were examined. The levels of IL-1 alpha, IL-1 beta, IL-6, IL-8, IL-10, TNF-alpha, VEGF, and TGF-beta proteins were determined.
Article
Critical Care Medicine
Mahircan Demir, Muhammed Cuneyd Gunay, Ibrahim Faruk Adiguzel, Varol Sahinturk
Summary: The treatment of large segmental bone defects is a challenging and time-consuming process. The induced membrane technique, which involves a two-step procedure of filling the defect with bone cement and then removing it and replacing it with cancellous bone autograft, is commonly used in this treatment. This study investigates the effects of adding antibiotics to the bone cement on the induced membrane. The results show that antibiotics added to the cement have negative effects on the membrane, and using antibiotic-free cement may be a better choice in aseptic nonunions.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Biochemistry & Molecular Biology
Sedat Kacar, Tugba Semerci Sevimli, Varol Sahinturk
Summary: The study aimed to investigate the effect of astaxanthin on human mesothelioma cells. Different doses of astaxanthin were used to treat the cells, and various analysis methods were employed to evaluate its effect on cell morphology, proliferation, and cell death. The results showed that astaxanthin exhibited anti-cancer effects on human mesothelioma cells, leading to changes in cell morphology, increased cell death, and alterations in oxidative stress response.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Surgery
Bartu Badak, Nuriye Ezgi Bektur Aykanat, Sedat Kacar, Varol Sahinturk, Deniz Arik, Funda Canaz
Summary: This study found that astaxanthin may be a promising therapeutic agent for breast cancer metastasis by increasing the activation of metastasis suppressing proteins. The expression levels of metastasis suppressors were higher in invasive ductal carcinoma tissues compared to in situ ductal carcinoma tissues. Further research on the effects of astaxanthin on breast cancer metastasis is warranted based on these results.
ANNALI ITALIANI DI CHIRURGIA
(2021)
Article
Multidisciplinary Sciences
Erhan Sahin, Sinem Dabagoglu Psav, Varol Sahinturk, Ayse Tansu Koparal
Summary: Quercetin was found to have a protective effect against sterile inflammation and oxidative stress induced by H2O2 in clone-9 liver cells by reducing the expression of NLRP3 and caspase-1 proteins.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2021)
Review
Cell Biology
Sedat Kacar, Varol Sahinturk
Summary: Acrylamide is a dangerous electrophile that can react with various biological molecules and is not only found in industrial areas but also in daily foods. Protective agents have been investigated to mitigate its toxicity, showing promising protective effects in in vitro studies. Focusing on mitigating acrylamide toxicity is crucial for future research and protection against this chemical exposure.