Article
Behavioral Sciences
Takafumi Kubota, Naoto Kuroda
Summary: This study found a higher proportion of epilepsy patients receiving telemedicine during the COVID-19 pandemic in the United States, and telemedicine may be associated with an increased risk of status epilepticus in patients with epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Apirada Thongsing, Donya Eizadkhah, Cheryl Fields, Karen Ballaban-Gil
Summary: This article reports 16 pediatric patients with seizures and COVID-19 during the surge of the Omicron variant, suggesting that this variant may be more likely to be associated with neurological symptoms, including complex provoked seizures, in the pediatric population compared to prior variants of SARS-CoV-2.
Article
Clinical Neurology
Felix Kohle, Marie Madlener, Emanuel Francesco Bruno, Gereon Rudolf Fink, Volker Limmroth, Lothar Burghaus, Michael Peter Malter
Summary: While the COVID-19 pandemic did not directly impact status epilepticus (SE) patients, it led to delays in transferring SE patients to emergency departments. Additionally, there was a shift in the etiology of SE cases, which calls for further exploration.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marc Rodrigo-Gisbert, Laura Gomez-Dabo, Manuel Quintana, Daniel Campos-Fernandez, Sofia Lallana, Elena Fonseca, Laura Abraira, Manuel Toledo, Estevo Santamarina
Summary: This study aimed to evaluate the risk of long-term seizure recurrence after status epilepticus (SE) and the potential risk factors associated with it. The results showed that progressive symptomatic etiology, delay in treatment initiation, and superrefractory SE were associated with a higher risk of seizure recurrence. On the other hand, older patients and acute symptomatic etiology had a lower risk of seizure recurrence.
Review
Behavioral Sciences
Fedele Dono, Bruna Nucera, Jacopo Lanzone, Giacomo Evangelista, Fabrizio Rinaldi, Rino Speranza, Serena Troisi, Lorenzo Tinti, Mirella Russo, Martina Di Pietro, Marco Onofrj, Laura Bonanni, Giovanni Assenza, Catello Vollono, Francesca Anzellotti, Francesco Brigo
Summary: SE is a neurological manifestation of SARS-CoV-2 infection, with age, time between acute respiratory phase of infection and SE onset, and hospitalization correlating with SE severity. The exact mechanisms linking SE and COVID-19 are not fully understood, but systemic inflammatory syndrome due to cytokine release may play a role.
EPILEPSY & BEHAVIOR
(2021)
Review
Behavioral Sciences
Takafumi Kubota, Prasannakumar Kanubhai Gajera, Naoto Kuroda
Summary: The EEG findings in patients with COVID-19 commonly showed abnormal background activity and generalized slowing, with epileptiform discharges present in 20.3% of cases. However, the proportion of seizures and status epilepticus on EEG was low, at 2.05% and 0.80%, respectively.
EPILEPSY & BEHAVIOR
(2021)
Article
Oncology
Jan Remsik, Jessica A. Wilcox, N. Esther Babady, Tracy A. McMillen, Behroze A. Vachha, Neil A. Halpern, Vikram Dhawan, Marc Rosenblum, Christine A. Iacobuzio-Donahue, Edward K. Avila, Bianca Santomasso, Adrienne Boire
Summary: Cancer patients with neurologic sequelae of COVID-19 have meningeal inflammatory cytokines without viral neuroinvasion, mainly driven by type II interferon and correlated with the degree of neurological dysfunction. The neuroinflammatory process persists weeks after recovery from acute respiratory infection, leading to long-term neurocognitive dysfunction. Anti-inflammatory treatments may play a role in managing neurological complications of COVID-19 infection.
Article
Clinical Neurology
Regina J. Faubel, Veronica S. Santos Canellas, Jenna Gaesser, Nancy H. Beluk, Tim N. Feinstein, Yong Wang, Maya Yankova, Kalyani B. Karunakaran, Stephen M. King, Madhavi K. Ganapathiraju, Cecilia W. Lo
Summary: This study reveals the association between abnormal motile cilia motion and flow pattern with epilepsy. These findings suggest that cilia regulating kinases may be potential therapeutic targets for medication-resistant epilepsy.
ACTA NEUROPATHOLOGICA
(2022)
Article
Neurosciences
Tianqi Wang, Chunpei Li, Yu Ma, Hao Zhou, Xiaonan Du, Yingfeng Li, Shasha Long, Yifeng Ding, Guoping Lu, Weiming Chen, Yuanfeng Zhou, Lifei Yu, Ji Wang, Yi Wang
Summary: This study aimed to identify prognostic biomarkers for status epilepticus (SE) in pediatric patients by analyzing metabolomics in cerebrospinal fluid (CSF). The researchers identified 49 prognosis-related metabolites and established a highly predictive prognostic model.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Annacarmen Nilo, Giada Pauletto, Simone Lorenzut, Giovanni Merlino, Lorenzo Verriello, Francesco Janes, Francesco Bax, Gian Luigi Gigli, Mariarosaria Valente
Summary: This study retrospectively analyzed 40 stroke patients with PSSE, including 14 cases of early-onset SE and 26 cases of late-onset SE. Early-onset SE was associated with more severe stroke and worse prognosis compared to late-onset SE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
David Garcia-Azorin, Maria Jose Abenza Abildua, Maria Elena Erro Aguirre, Santiago Fernandez Fernandez, Juan Carlos Garcia Monco, Cristina Guijarro-Castro, Montserrat Gonzalez Platas, Fernando Romero Delgado, Jose Miguel Lainez Andres, David Ezpeleta
Summary: The findings from the Spanish Society of Neurology's NeuroCOVID-19 Registry revealed diverse neurological manifestations of COVID-19, including stroke, neuromuscular symptoms, altered mental status, anosmia, headache, and seizures. Some symptoms had different onset times. COVID-19 could cause persistent and disabling neurological symptoms, with certain symptoms associated with greater severity.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Theodore Sheehan, Marta Amengual-Gual, Alejandra Vasquez, Nicholas S. Abend, Anne Anderson, Brian Appavu, Ravindra Arya, Cristina Barcia Aguilar, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William D. Gaillard, Marina Gainza-Lein, Tracy A. Glauser, Joshua L. Goldstein, Howard P. Goodkin, Rejean M. Guerriero, Linda Huh, Michele Jackson, Kush Kapur, Robert Kahoud, Yi-Chen Lai, Tiffani L. McDonough, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorf, Eric T. Payne, Katrina Peariso, Juan Piantino, Latania Reece, James J. Riviello, Tristan T. Sands, Kumar Sannagowdara, Renee Shellhaas, Garnett Smith, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjian, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Bo Zhang, Tobias Loddenkemper
Summary: This study evaluated benzodiazepine administration patterns in pediatric patients with refractory convulsive status epilepticus before transitioning to non-Benzodiazepine antiseizure medication (ASM). Findings include over one-third of patients receiving more than two benzodiazepines before transitioning, and delays in treatment initiation reducing the likelihood of multiple benzodiazepine doses. Patients with out-of-hospital seizure onset were more likely to receive additional benzodiazepines beyond 30 and 45 minutes, and intermittent SE was a risk factor for more benzodiazepines administered beyond 45 minutes.
Article
Critical Care Medicine
Zachary S. Daniels, Nina Srdanovic, Karen Rychlik, Craig Smith, Joshua Goldstein, Alfred L. George
Summary: This study aimed to describe the prevalence of midazolam treatment failure in children with refractory status epilepticus (RSE) and define a threshold dose associated with diminishing frequency of seizure cessation. The results showed an association between the maximum midazolam dose and seizure cessation, with patients more likely to fail treatment when administered at higher doses.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Zachary S. Daniels, Nina Srdanovic, Karen Rychlik, Craig Smith, Joshua Goldstein, Alfred L. George
Summary: This study aimed to describe the prevalence of midazolam treatment failure in children with refractory status epilepticus (RSE) and determine a threshold dose associated with decreasing seizure cessation frequency. The results showed that patients were more likely to fail treatment when administered midazolam at higher doses, and treatment above 525μg/kg/hr was associated with diminishing frequency of seizure cessation.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Paulina S. C. Kliem, Kai Tisljar, Sira M. Baumann, Pascale Grzonka, Gian Marco De Marchis, Stefano Bassetti, Roland Bingisser, Sabina Hunziker, Stephan Marsch, Raoul Sutter
Summary: Respiratory infections following status epilepticus (SE) are frequent and associated with higher mortality, prolonged ICU stay, and higher rates of refractory SE. Lack of airway protection may contribute to respiratory infectious complications. This study investigates the order and frequency of physicians treating a simulated SE following a systematic Airways-Breathing-Circulation-Disability-Exposure (ABCDE) approach, identifies risk factors for non-adherence, and analyzes the compliance of an ABCDE guided approach to SE with current guidelines. The study found that adherence to the ABCDE approach was infrequent, but when followed, it resulted in better airway protection and adherence to treatment steps.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ethics
Ariane Lewis
Summary: This article examines the management of court cases in the United Kingdom regarding objections to the use of neurologic criteria to determine death. It summarizes important legal cases and discusses ethical issues raised by these challenges, comparing them to the situation in the USA.
AMERICAN JOURNAL OF BIOETHICS
(2023)
Article
Clinical Neurology
Ariane Lewis, Steven Galetta
Summary: In their research article, Chassoux et al. conducted a retrospective review on 60 patients with focal cortical dysplasia type 2 (FCD2) in the central region who underwent surgical resection. They found that 88% of patients achieved seizure freedom after surgery, and although 87% experienced early transitory postoperative deficits, 40% of them fully recovered. It was also observed that patients with FCD2 can have preoperative and postoperative neurologic deficits, and some patients showed improvement after surgery.
Review
Medicine, General & Internal
Ariane Lewis
Summary: This manuscript explores the international variability in the diagnosis and management of disorders of consciousness (DoC). The impact of financial, legal, cultural, religious, and psychosocial considerations on DoC diagnosis and management is discussed. Improvements in clinical care, education, advocacy, and research are needed globally. Standardized methodology for evaluating consciousness and prognosticating outcome is imperative, as well as education to raise awareness and develop communication techniques about DoC. Equity in access to expertise and resources is necessary, along with harmonization of existing datasets and establishment of international clinical trial networks.
Article
Clinical Neurology
Cen Zhang, Arielle Kurzweil, Perrin Pleninger, Aaron Nelson, Lindsey Gurin, Sondra Zabar, Steven L. Galetta, Laura J. Balcer, Ariane Lewis
Summary: A survey of NYU neurology teaching faculty found a high proportion of discomfort and lack of experience in providing negative feedback, debriefing after an adverse outcome, and assisting struggling colleagues. Female faculty and those early in their careers were more likely to feel uncomfortable. Faculty development is needed to improve communication skills.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jennifer A. Frontera, Ariane Lewis, Les James, Kara Melmed, Brendan Parent, Eytan Raz, Syed T. Hussain, Deane E. Smith, Nader Moazami
Summary: The use of thoracoabdominal normothermic regional perfusion (TA-NRP) in donation after circulatory death (DCD) is an important development in organ donation. However, there have been concerns about the restoration of brain blood flow. In this study, the authors used intraoperative transcranial Doppler (TCD) to assess brain blood flow in two DCD TA-NRP cases and found no evidence of restored blood flow.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Critical Care Medicine
Ariane J. Lewis, Michael Young, Benjamin J. Rohaut, Ralf Jox, Jan J. Claassen, Claire Creutzfeldt, Judy Illes, Matthew Kirschen, Stephen J. Trevick, Joseph Fins
Summary: Interest in disorders of consciousness (DoC) has increased, highlighting the importance of understanding DoC biology, care needs, treatment options, and outcome prediction. Ethical considerations related to rights and resources should be taken into account when conducting research on DoC.
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Danielle Feng, Ariane Lewis
NEUROLOGIC CLINICS
(2023)
Article
Clinical Neurology
Steven Galetta, Aravind Ganesh, Ariane Lewis, James E. Siegler III
Summary: Dr. Siow et al. found associations between the glymphatic function assessed by DTI-ALPS index and sleep, neuropsychological performance, and cerebral gray matter volumes. Higher DTI-APLS was associated with better cognitive performance and higher gray matter volume, suggesting it as a potential biomarker for cognitive disorders. However, the reproducibility of this new MRI technique is still under investigation.
Article
Clinical Neurology
Megan Finneran, Ariane Lewis
Summary: There is a call for the neuroscience community to promote uniformity in the determination of brain death/death by neurologic criteria (BD/DNC). Engaging with state medical societies is one way to achieve this advocacy. The principal author recognized the ambiguity and inconsistency in her hospital's policy on BD/DNC determination, leading her to propose a resolution to the Illinois State Medical Society (ISMS) in order to encourage uniformity across the state. Although ISMS approved the resolution, its effectiveness remains uncertain due to certain shortcomings. Nevertheless, other neuroscience clinicians are encouraged to collaborate with their respective state medical societies to advocate for uniformity in BD/DNC determination.
Article
Critical Care Medicine
Sung-Min Cho, Chiara Robba, Michael N. Diringer, Daniel F. Hanley, J. Claude Hemphill, Janneke Horn, Ariane Lewis, Sarah L. Livesay, David Menon, Tarek Sharshar, Robert D. Stevens, James Torner, Paul M. Vespa, Wendy C. Ziai, Marcus Spann, Raimund Helbok, Jose Suarez
Summary: To address the lack of knowledge regarding clinical trial design for patients with disorders of consciousness (DoC), a research group conducted a gap analysis and proposed optimal clinical trial designs for DoC studies.
NEUROCRITICAL CARE
(2023)
Article
Critical Care Medicine
Ariane Lewis
Summary: This article discusses the pause in the revision of the Uniform Determination of Death Act (UDDA) by the Uniform Law Commission, and the thematic review of comments submitted by medical organizations, organ procurement organizations, and advocacy organizations. While most organizations support revision, there are differing viewpoints on the approach, making it difficult to reach a consensus.
NEUROCRITICAL CARE
(2023)
Letter
Clinical Neurology
Ariane Lewis, Steven Galetta
Letter
Clinical Neurology
Steven E. Galetta, Aravind Ganesh, Ariane Lewis, James E. Siegler III
Summary: International guidelines recommend intravenous anesthesia for 24-48 hours to treat refractory status epilepticus, but the cessation of seizures in patients with this condition is poorly defined. In a retrospective analysis of 147 patients, the achievement of burst suppression on EEG was not associated with termination of seizures, survival, or return to pre-illness level of function. However, in patients with anoxic brain injury, a higher degree of burst suppression was linked to increased odds of seizure termination and in-hospital survival.
Letter
Clinical Neurology
Ariane Lewis, Steven Galetta
Correction
Clinical Neurology
Steven Galetta, Aravind Ganesh, Ariane Lewis, James E. Siegler III