CD4+ T cells are essential for the development of destructive thyroiditis induced by anti–PD-1 antibody in thyroglobulin-immunized mice

Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

(2020) Norio Okada et al.   BRITISH JOURNAL OF CANCER

Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study

(2020) Tomoko Kobayashi et al.   Journal for ImmunoTherapy of Cancer

Low frequency of positive antithyroid antibodies is observed in patients with thyroid dysfunction related to immune check point inhibitors

(2019) I. Mazarico et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Sequential Blockade of PD-1 and PD-L1 Causes Fulminant Cardiotoxicity—From Case Report to Mouse Model Validation

(2019) Shin-Yi Liu et al.   Cancers

PD-L1 Inhibitor-Induced Thyroiditis Is Associated with Better Overall Survival in Cancer Patients

(2019) Anupam Kotwal et al.   THYROID

Characterization of CD4 + T cell-mediated cytotoxicity in patients with multiple myeloma

(2018) Xiaole Zhang et al.   CELLULAR IMMUNOLOGY

Association of increased eomesodermin, BCL6, and granzyme B expression with major clinical manifestations of Hashimoto’s thyroiditis – an observational study

(2018) Mario Štefanić et al.   IMMUNOLOGICAL INVESTIGATIONS

Critical role of rabphilin-3A in the pathophysiology of experimental lymphocytic neurohypophysitis

(2018) Yoshinori Yasuda et al.   JOURNAL OF PATHOLOGY

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

(2018) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling by the Epstein–Barr virus LMP1 protein induces potent cytotoxic CD4+and CD8+T cell responses

(2018) Il-Kyu Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of anti-thyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab

(2018) Shiro Kimbara et al.   CANCER SCIENCE

Papillary Thyroid Carcinoma Emerging from Hashimoto Thyroiditis Demonstrates Increased PD-L1 Expression, Which Persists with Metastasis

(2018) Daniel Lubin et al.   ENDOCRINE PATHOLOGY

HBHA-Induced Polycytotoxic CD4+ T Lymphocytes Are Associated with the Control of Mycobacterium tuberculosis Infection in Humans

(2018) Laetitia Aerts et al.   JOURNAL OF IMMUNOLOGY

Histology of Nivolumab-Induced Thyroiditis

(2018) Christina Neppl et al.   THYROID

Clinical response to PD-1 blockade correlates with a sub-fraction of peripheral central memory CD4+ T cells in patients with malignant melanoma

(2017) Yoshiko Takeuchi et al.   INTERNATIONAL IMMUNOLOGY

Colon Immune-Related Adverse Events: Anti-CTLA-4 and Anti-PD-1 Blockade Induce Distinct Immunopathological Entities

(2017) Clélia Coutzac et al.   Journal of Crohns & Colitis

Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients

(2017) Alice O. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4 CTL, a Cytotoxic Subset of CD4+ T Cells, Their Differentiation and Function

(2017) Arata Takeuchi et al.   Frontiers in Immunology

Antibody-Mediated Thyroid Dysfunction During T-cell Checkpoint Blockade in Patients with Non-Small Cell Lung Cancer

(2016) J.C. Osorio et al.   ANNALS OF ONCOLOGY

Lesional CD4 + IFN-γ + cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis

(2016) Takashi Maehara et al.   ANNALS OF THE RHEUMATIC DISEASES

Acute Lymphocytic Myocarditis With Anti-PD-1 Antibody Nivolumab

(2016) Tomonori Tadokoro et al.   Circulation-Heart Failure

Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse

(2016) Tadashi Ashizawa et al.   CLINICAL CANCER RESEARCH

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis

(2016) Naoko Iwata et al.   Pituitary

CRTAM determines the CD4+cytotoxic T lymphocyte lineage

(2015) Arata Takeuchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

(2015) Ben J. E. Raveney et al.   Nature Communications

NKT cell-targeted vaccination plus anti-4–1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma

(2015) Takumi Kobayashi et al.   OncoImmunology

Hashimoto thyroiditis: Clinical and diagnostic criteria

(2014) P. Caturegli et al.   AUTOIMMUNITY REVIEWS

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Pituitary Expression of CTLA-4 Mediates Hypophysitis Secondary to Administration of CTLA-4 Blocking Antibody

(2014) S. Iwama et al.   Science Translational Medicine

Memory T Cell Subsets, Migration Patterns, and Tissue Residence

(2012) Scott N. Mueller et al.   Annual Review of Immunology

Hürthle Cells Predict Hypothyroidism in Interferon-γ Transgenic Mice of Different Genetic Backgrounds

(2012) Shintaro Iwama et al.   ENDOCRINOLOGY

Antiviral T Cell Response Triggers Cytomegalovirus Hepatitis in Mice

(2012) D. Livingston-Rosanoff et al.   JOURNAL OF VIROLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hashimoto's Thyroiditis: Celebrating the Centennial Through the Lens of the Johns Hopkins Hospital Surgical Pathology Records

(2012) Patrizio Caturegli et al.   THYROID

Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease

(2010) Z. WU et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Time-dependent changes in proinflammatory and neurotrophic responses of microglia and astrocytes in a rat model of osmotic demyelination syndrome

(2010) Shintaro Iwama et al.   GLIA

Tumor-reactive CD4+T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

(2010) Sergio A. Quezada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection

(2009) C. M. Snyder et al.   JOURNAL OF IMMUNOLOGY

Autoimmune Hypophysitis of SJL Mice: Clinical Insights from a New Animal Model

(2008) Shey-Cherng Tzou et al.   ENDOCRINOLOGY