Article
Environmental Sciences
Chenxi Zhao, Ruihui Xie, Qiuhui Qian, Jin Yan, Huili Wang, Xuedong Wang
Summary: This study observed the effects of acute triclosan (TCS) exposure on the differentiation and development of immune cells using transgenic zebrafish models. It was found that TCS exposure caused abnormalities in innate and adaptive immune cells, possibly triggering a cytokine storm. The study also identified the molecular mechanisms behind TCS-induced immunotoxicity, involving the up-regulation of miR-19a and activation of the IL-6/STAT3 signaling pathway.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Cell Biology
Mei Huang, Jianmin Guo, Lifei Liu, Haiming Jin, Xi Chen, Jun Zou
Summary: Osteoporosis is a common bone disease with unclear mechanisms. The m6A demethylase FTO plays an important role in regulating bone metabolism and osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Environmental Sciences
Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu
Summary: The study found that both Cr (III) and Cr (VI) can interfere with one carbon metabolism, affecting DNA methylation and histone methylation to regulate the expression of neuro-related genes, leading to neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Gastroenterology & Hepatology
Haiming Zheng, Meiying Zhu, Wenhua Li, Zunqiang Zhou, Xinjian Wan
Summary: This study found that NKILA is significantly upregulated in CCA and its overexpression is associated with poor prognosis in CCA patients. NKILA can promote CCA growth and metastasis, interact with NSUN2 and miR-582-3p, and function via YAP1 in CCA.
LIVER INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Jianong Zhang, Jiangbo Wei, Rui Sun, Haoyue Sheng, Kai Yin, Yunqian Pan, Rafael Jimenez, Sujun Chen, Xiao-long Cui, Zhongyu Zou, Zhiying Yue, Michael J. Emch, John R. Hawse, Liguo Wang, Housheng Hansen He, Shujie Xia, Bangmin Han, Chuan He, Haojie Huang
Summary: The FTO-IT1 lncRNA is upregulated in wild-type p53-expressing prostate cancer patients and is associated with poor survival. It acts by binding to RBM15 and inhibiting the methylation and stability of p53 target mRNAs. Therapeutic depletion of FTO-IT1 restores mRNA m(6)A level and expression of p53 target genes, leading to inhibition of tumor growth.
Article
Toxicology
Mahaboubeh Hosseinzadeh, Alejandra Gilabert, Cinta Porte
Summary: This study investigates the effects of the antimicrobial triclosan (TCS) on the digestive gland of mussels using precision-cut tissue slices (PCTS). The results demonstrate that TCS disrupts the expression of genes related to energy, phenylalanine, and lipid metabolism, and alters lipid dynamics in mussels.
TOXICOLOGY IN VITRO
(2022)
Article
Cell Biology
Weifeng Yang, Lei Xie, Peng Wang, Changshui Zhuang
Summary: miR-155 targets FTO to negatively regulate its expression and increase m6A level in ccRCC, promoting tumor cell proliferation and decreasing apoptosis.
CELLULAR SIGNALLING
(2022)
Article
Gastroenterology & Hepatology
Yanru Ma, Xinyu Zhang, Baoqin Xuan, Danjie Li, Nan Yin, Lijun Ning, Yi-Lu Zhou, Yuqing Yan, Tianying Tong, Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Zhenhua Wang, Zhe Cui, Huabin Li, Jiqiu Wang, Jing-Yuan Fang, Ruixin Liu, Haoyan Chen, Jie Hong
Summary: FTO downregulation promotes UC by decreasing CerS6 expression, resulting in increased S1P accumulation in IECs and exacerbating colitis via m6A-dependent mechanisms. UC patients with lower FTO expression may have a better response to vedolizumab treatment.
Article
Medicine, Research & Experimental
Kaiju Sun, Yangyang Du, Yuzhu Hou, Mingyue Zhao, Jiajia Li, Yazhe Du, Lingxiao Zhang, Changbao Chen, Hongmei Yang, Fei Yan, Rui Su
Summary: The study revealed that SsD has broad anti-proliferation effects in AML by targeting FTO/m(6)A signaling pathway, increasing global m(6)A RNA methylation levels, and suppressing relevant pathways affecting AML cell proliferation.
Article
Biochemistry & Molecular Biology
Dongqin Wei, Qian Sun, Yizhou Li, Chaowei Li, Xinjian Li, Chao Sun
Summary: The study revealed that leptin can reduce the m(6)A methylation of Plin5 by promoting FTO, affecting lipid metabolism and energy consumption, providing a theoretical basis for treating diseases related to obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xiancheng Wan, Huili Wang, Qiuhui Qian, Jin Yan
Summary: In this study, we investigated the toxic effects of triclosan (TCS) exposure on heart development in zebrafish embryos. TCS exposure caused significant cardiac dysfunction, oxidative damage, and abnormal apoptosis in heart cells. The upregulation of beta-adrenergic receptor (beta-AR) signaling pathway genes and downregulation of miR-133b were found to contribute to TCS-induced cardiotoxicity.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Zhanmin Liang, Haokai Ye, Jiongming Ma, Zhen Wei, Yue Wang, Yuxin Zhang, Daiyun Huang, Bowen Song, Jia Meng, Daniel J. Rigden, Kunqi Chen
Summary: m(6)A-Atlas v2.0 is a valuable research tool that includes a large number of m(6)A sites and their functional annotations from different technologies and experimental conditions, to facilitate the study of this important RNA modification.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoran Duan, Li Yang, Liuya Wang, Qinghua Liu, Kai Zhang, Shasha Liu, Chaojun Liu, Qun Gao, Lifeng Li, Guohui Qin, Yi Zhang
Summary: This study found that the highly expressed m6A demethylase FTO in esophageal cancer cells can regulate the formation of lipid droplets by affecting the translation pathway of the HSD17B11 gene, thereby promoting the development of esophageal cancer.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Xueyu Wang, Mingo M. H. Yung, Rakesh Sharma, Fushun Chen, Ying-Tung Poon, Wai-Yip Lam, Benjamin Li, Hextan Y. S. Ngan, Karen K. L. Chan, David W. W. Chan
Summary: The study reveals that miR-33b is frequently silenced by DNA hypermethylation in metastatic ovarian cancer cells, and its restoration can impair lipid metabolic activities and reduce oncogenic properties, potentially serving as a therapeutic target for ovarian cancer metastatic progression.
Article
Marine & Freshwater Biology
Chenyan Hu, Baili Sun, Lizhu Tang, Mengyuan Liu, Zileng Huang, Xiangzhen Zhou, Lianguo Chen
Summary: This study investigates the hepatotoxicity of methylparaben (MeP) in adult zebrafish exposed to environmentally realistic concentrations of MeP. The results show that MeP exposure induces hepatocellular vacuolization in zebrafish and disrupts the balance between oxidative stress and antioxidant capacity. MeP exposure also dysregulates lipid metabolism and alters the concentrations of key metabolites. Overall, this study highlights the hepatotoxic effects of MeP even at environmentally realistic concentrations.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)