Article
Physiology
Jon Stavres, J. Carter Luck, Takuto Hamaoka, Cheryl Blaha, Aimee Cauffman, Paul C. Dalton, Michael D. Herr, Victor Ruiz-Velasco, Zyad J. Carr, Piotr Janicki, Jian Cui
Summary: The study aimed to investigate the effects of amiloride on exercise tolerance and blood pressure during blood-flow-restricted (BFR) exercise in healthy adults. The results demonstrated that a single oral dose of 10 mg amiloride significantly increased time to failure and time-tension index, while not affecting perceived pain. However, amiloride had no significant influence on mean blood pressure and heart rate responses.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Bruno Costa Teixeira, Franccesco Pinto Boeno, Jeam Marcel Geremia, Cleiton da Silva Correa, Andre Luiz Lopes, Rodrigo Cauduro Oliveira Macedo, Randhall Bruce Kreismann Carteri, Eliane Bandinelli, Marco Aurelio Vaz, Jerri Luiz Ribeiro, Alvaro Reischak-Oliveira
Summary: Different types of muscle contraction have different effects on the musculature and inflammatory responses. Acute increases in inflammation markers can increase the risk of thrombus formation and cardiovascular events. This study investigates the effects of concentric and eccentric exercise on hemostasis markers and CRP levels.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Zhixiong Zhou, Lindong Hou, Mengnan Cui, Laurent Mourot, Weili Zhu
Summary: This study compared the acute effects of low-volume intermittent exercise and higher-volume continuous exercise on arterial stiffness. The results showed that despite the lower volume, intermittent exercise may have equal or superior effects on arterial stiffness compared to higher-volume continuous exercise.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Eric Evans, Jean-Philippe Walhin, Aaron Hengist, James A. Betts, David J. Dearlove, Javier T. Gonzalez
Summary: This study is the first to show that ingestion of a ketone monoester postexercise can increase serum erythropoietin concentrations and decrease serum glucose concentrations in healthy men. These findings suggest the potential for ketone monoesters to modify hemoglobin mass.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Clinical Neurology
Jessica A. Peterson, Michael G. Bemben, Rebecca D. Larson, Hugo Pereira, H. Michael Crowson, Christopher D. Black
Summary: This study reveals that CPM was impaired in individuals who had symptomatic COVID-19, which may have long-term implications on pain modulation.
Article
Cell Biology
Jan-Frieder Harmsen, Michel van Weeghel, Rex Parsons, Georges E. Janssens, Jakob Wefers, Dirk van Moorsel, Jan Hansen, Joris Hoeks, Matthijs K. C. Hesselink, Riekelt H. Houtkooper, Patrick Schrauwen
Summary: This study investigates the 24-hour muscle metabolome in young, healthy men and older, metabolically compromised men. The results show that metabolites involved in glycolysis and hexosamine biosynthesis are increased in the metabolically compromised men, while metabolites related to glutamine-alpha-ketoglutarate, ketone, and redox metabolism are decreased. The findings suggest a plasticity of the skeletal muscle metabolome over the 24-hour period and significant differences between healthy and metabolically compromised individuals.
Article
Multidisciplinary Sciences
Tomas Venckunas, Hans Degens
Summary: This study investigated the associations between 16 genetic polymorphisms and muscle fitness in a group of healthy young males. The results showed that nine of the studied polymorphisms were independently associated with skeletal muscle fitness measures and explained up to 4.1% of their variation. Additionally, a combination of five polymorphisms with body height, age, and/or athletic group explained up to 20.4% of muscle function variation.
Article
Biology
Victor Domenech-Garcia, Shellie Ann Boudreau, Rafael Giner-Nicolas, Pablo Bellosta-Lopez
Summary: Acute musculoskeletal injuries result in changes in swelling, redness, hyperalgesia, and expanded pain distribution. This study assessed mechanical muscle hyperalgesia, skin temperature, and pain intensity and distribution during the recovery process following eccentric exercise in the hamstring muscles. The results showed that pain-related variables and thermographic changes had different recovery times.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Physiology
Baubak Shamim, Donny M. Camera, Jamie Whitfield
Summary: In this study, it was found that resistance, endurance, and concurrent training can similarly induce myofibre hypertrophy without expansion of satellite cell and myonuclear pool. Additionally, the results suggest that myonuclear accretion via satellite cell fusion is positively correlated with hypertrophy after 12 weeks of concurrent training.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Daichi Shima, Yukihide Nishimura, Takamasa Hashizaki, Yuta Minoshima, Tatsuya Yoshikawa, Yasunori Umemoto, Tokio Kinoshita, Ken Kouda, Fumihiro Tajima, Yoshi-Ichiro Kamijo
Summary: The study investigated whether arm and leg ergometer exercises could be used for core strengthening and whether different exercise sites would affect the results. The results showed that both arm and leg ergometer exercises effectively increased muscle activity in the erector spinae and multifidus. This provides an alternative method for individuals who are unable to perform traditional core strengthening exercises.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Ferdinand Roelfsema, Rebecca Yang, Johannes D. Veldhuis
Summary: This study demonstrates that IL-2 temporarily diminishes GH secretion in young, but not older, men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Ulla Kampmann, Esben S. Lauritzen, Niels Grarup, Niels Jessen, Torben Hansen, Niels Moller, Julie Stoy
Summary: The study found that acute administration of high doses of melatonin may reduce insulin sensitivity, especially in certain genotype carriers.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Evan K. Pacey, Hafiz Maherali, Brian C. Husband
Summary: Whole-genome duplication, leading to polyploidy and endopolyploidy, is widespread in the tree of life. Increased cell size following genome duplication can increase plant storage capacity and tolerance to resource limitation, but incurs biomechanical costs. The functional consequences of autopolyploidy can vary with accession identity, suggesting potential for adaptation following whole-genome duplication.
Article
Cardiac & Cardiovascular Systems
Hannah J. Thomas, Channa E. Marsh, Louise H. Naylor, Philip N. Ainslie, Kurt J. Smith, Howard H. Carter, Daniel J. Green
Summary: The study found that resistance training decreased middle cerebral artery velocity and pulsatility index, while increasing mean arterial pressure and indices of cerebrovascular resistance, whereas endurance training did not have this effect. This suggests that resistance training may increase cerebrovascular resistance, which could have implications for brain health.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Sina Kistner, Carina I. Mack, Manuela J. Rist, Ralf Krueger, Bjoern Egert, Nathalie Biniaminov, Ann Katrin Engelbert, Stephanie Seifert, Claudia Doerr, Paola G. Ferrario, Rainer Neumann, Stefan Altmann, Achim Bub
Summary: Endurance exercise has beneficial effects on performance and health, but the mechanisms underlying the body's adaptations to different exercise protocols are not fully understood. This study used a metabolomics approach to identify urinary metabolites and pathways that distinguish the acute metabolic response to two endurance exercise interventions at different intensities.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Bettina Eiger, Mette Errebo, Christian Lund Straszek, Henrik Bjarke Vaegter
Summary: This study evaluated the test-retest reliability and measurement error of the Danish versions of the Tampa Scale of Kinesiophobia (TSK) in patients with chronic pain. The results showed good to excellent test-retest reliability for TSK-11, TSK-13, and TSK-17, and reported SEM and SDC95% values for patients. TSK-11 may be preferred to minimize responder burden.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Luke C. Jenkins, Wei-Ju Chang, Valentina Buscemi, Matthew Liston, Peter Humburg, Michael Nicholas, Thomas Graven-Nielsen, Paul W. Hodges, James H. McAuley, Siobhan M. Schabrun
Summary: This study aims to identify neurobiological and psychological risk factors for the development of chronic low back pain. Factors such as medical history, age, and emotional state have a significant impact on the development of chronic low back pain. Neurobiological risk factors explain an additional 15% of the variance in pain intensity at 6 months.
Article
Clinical Neurology
Luisina Gregoret, Anna M. Zamorano, Thomas Graven-Nielsen
Summary: This study investigates the effects of multifocal transcranial direct current stimulation (tDCS) on cortical plasticity in different brain regions. It demonstrates that by targeting the resting-state motor network, multifocal tDCS can reverse attenuated N2-P2 cortical responses during prolonged experimental pain.
Article
Anesthesiology
Sebastian Kold, Thomas Graven-Nielsen
Summary: This study investigated the effects of HD-tDCS on central pain mechanisms in healthy participants. The results showed that HD-tDCS can reduce the facilitation of pain caused by tonic pain, but has no significant effects on other pain parameters.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Anna M. Zamorano, Boris Kleber, Federico Arguissain, Shellie Boudreau, Peter Vuust, Herta Flor, Thomas Graven -Nielsen
Summary: Repetitive movements are a major risk factor for musculoskeletal pain and can lead to brain plasticity changes. This study aimed to investigate the brain processing of prolonged muscle pain in musicians. The results showed that musicians had lower pain intensity compared to non-musicians, and higher training volume was associated with lower pain scores.
Article
Psychiatry
Amalie Munk Eefsen, Marie Weinreich Petersen, Henrik Bjarke Vaegter, Kirsten Fonager, Mathias Skjernov, Lise Gormsen, Andreas Schroder
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Health Policy & Services
Steffan Wittrup McPhee Christensen, M. Heidi Almsborg, M. Thomas Sogaard Vain, Henrik Bjarke Vaegter
Summary: This study investigated the effect of virtual reality (VR) on pain threshold, tolerance, and intensity in fibromyalgia patients and pain-free individuals. The results showed that VR significantly increased pain threshold and tolerance in both groups, and reduced pain intensity only in pain-free individuals. Pain catastrophizing was not related to VR effect. These findings support the use of VR as a pain management tool.
GAMES FOR HEALTH JOURNAL
(2023)
Article
Clinical Neurology
Christina Titze, Kerstin Konietzny, Hannah Gajsar, Kelli Koltyn, Omar Chehadi, Monika I. Hasenbring, Henrik Bjarke Vaegter
Summary: Two experiments explored the relationship between spontaneous and instructed mindful monitoring and exercise-induced pain reduction and low pain thresholds. The findings suggest that spontaneous mindful monitoring is associated with less exercise-induced unpleasantness, while spontaneous thought suppression is associated with higher unpleasantness. Instructed thought suppression may have an impact on exercise-induced hypoalgesia.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Engineering, Industrial
Steffan Wittrup McPhee Christensen, Thorvaldur Skuli Palsson, Hans Jurgen Krebs, Thomas Graven-Nielsen, Rogerio Pessoto Hirata
Summary: This study investigated the effects of sitting posture on spinal pain, sensitivity, and muscle activity. The results showed that regardless of posture, each task caused an increase in pain, although some tasks caused larger changes than others.
APPLIED ERGONOMICS
(2023)
Article
Neurosciences
Enrico De Martino, Adenauer Casali, Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Thomas Graven-Nielsen, Daniel Ciampi de Andrade
Summary: Pain-related changes in cortical excitability were investigated in the dorsolateral prefrontal cortex and primary motor cortex using transcranial magnetic stimulation-electroencephalography. Acute pain decreased peak-to-peak amplitude in both M1 and dorsolateral prefrontal cortex, while only M1 showed a reduction in global-mean field power. Participants with the greatest reduction in local cortical excitability under acute pain showed a negative correlation between dorsolateral prefrontal cortex and M1. These findings highlight the differential effects of acute pain on local and global cortical excitability, as well as individual patterns of cortical excitability changes.
Article
Neurosciences
Priscilla Geraldine Wittkopf, Dennis Boye Larsen, Luisina Gregoret, Thomas Graven-Nielsen
Summary: This study investigated the effects of prolonged experimental pain on homeostatic plasticity (HP) and if pain relief modulates disrupted HP. The results showed that capsaicin pain disrupted HP, and pain relief induced by ice did not restore HP.
Article
Clinical Neurology
Eva Laerkner, Laila Bendix, Madalina Jager, Maj-Britt Hansen, Henrik Bjarke Vaegter
Summary: This study examines the experiences, perceived usability, and challenges of the Smerteinfo website among patients with high-impact chronic pain. The results show that the website is valuable and suggests spreading knowledge of the site to general practitioners at an earlier stage of illness. Continuous improvement and expansion of the site based on scientific evidence and in collaboration with end-users are crucial.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Psychology, Clinical
Maj Hansen, Henrik Bjarke Vaegter, Sophie Lykkegaard Ravn, Tonny Elmose Andersen
Summary: Validating PTSD screening tools in trauma-exposed chronic pain patients is crucial due to the high symptom overlap between PTSD and pain. This study aimed to validate the PCL-5 in a sample of trauma-exposed, treatment-seeking chronic pain patients and found satisfactory psychometric properties.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2023)
Article
Clinical Neurology
Svetlana Solgaard Nielsen, Soren T. Skou, Anette Enemark Larsen, Romanas Polianskis, Lars Arendt-Nielsen, Anne Skov Ostergaard, Kristian Kjaer-Staal Petersen, Henrik Bjarke Vaegter, Jens Sondergaard, Jeanette Reffstrup Christensen
Summary: This study investigated the impact of an occupational therapy lifestyle intervention on pain-related parameters, occupational function, occupational balance, lifestyle factors, and self-perceived health status in adults with chronic high-impact pain. The study found that the intervention appeared to improve motor skills but did not have clear effects on other outcomes. Further research, such as a randomized trial, is needed to confirm these findings.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Anesthesiology
Andrea Aagaard, Sophie Lykkegaard Ravn, Tonny Elmose Andersen, Henrik Bjarke Vaegter
Summary: This study investigated how patients with high-impact chronic pain interpreted and responded to the Patient Health Questionnaire 9 (PHQ-9) to identify problematic items and causes hereof. The study found that there are problematic items in the PHQ-9 which limit its diagnostic accuracy for depression in patients with high-impact chronic pain.
CLINICAL JOURNAL OF PAIN
(2023)