Article
Oncology
Dawn P. Liew, Manuel Roehrich, Lisa Loi, Sebastian Adeberg, Mustafa Syed, Ewgenija Gutjahr, Heinz Peter Schlemmer, Frederik L. Giesel, Martin Bendszus, Uwe Haberkorn, Daniel Paech
Summary: The study analysed the correlation between Ga-68-FAPI PET signals and MRI signals in 12 ACC patients. The results showed very weak positive correlations between Ga-68-FAPI PET signals and ceT1w values, and weak negative correlations with T2w values. This indicates that Ga-68-FAPI PET signalling is an independent signal in ACC patients, not just a surrogate marker of MRI sequences.
Review
Medicine, General & Internal
Yan Cui, Yuxiang Wang, Shu Wang, Bulin Du, Xuena Li, Yaming Li
Summary: Fibrosis is a common healing process in cardiovascular diseases that is associated with disease states and causes adverse effects. Early detection of activated fibroblasts is crucial for patient management and prognosis. FAPI PET imaging has emerged as a useful tool in early detection of cardiovascular fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hui-ru Jian, Wen-hao Niu, Zhuo-shuo Xu, Jia-xu Zhu, Xin Pan, Yi-rui Zhang, Ping Lei, Fa-qing Huang, Yong He
Summary: This study successfully established a pair of cell lines, one highly expressing FAP (HT1080-hFAP) and the other with no detectable FAP (HT1080-vec), as a control, to accurately evaluate the specificity of FAP-targeted theranostics. The results demonstrated that HT1080-hFAP cells had high expression of FAP, while HT1080-vec cells did not. PET imaging showed that HT1080-hFAP tumors had superior selectivity in binding and uptake of (68)GA-FAPI-04.
CURRENT MEDICAL SCIENCE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Paul Windisch, Daniel R. Zwahlen, Frederik L. Giesel, Eberhard Scholz, Patrick Lugenbiel, Juergen Debus, Uwe Haberkorn, Sebastian Adeberg
Summary: The study summarized evidence on the clinical use of FAP-specific PET in non-malignant diseases, including its potential for cardiac imaging, IgG(4)-related disease, benign tumors, and various inflammations. Two prospective studies showed promise in differentiating inflammatory from fibrotic lesions with FAP-specific PET, particularly for IgG(4)-related disease.
Article
Oncology
Xinfeng Lin, Yingjie Li, Shuailiang Wang, Yan Zhang, Xuetao Chen, Maomao Wei, Hua Zhu, Aiwen Wu, Zhi Yang, Xuejuan Wang
Summary: This study compared the diagnostic performance of [Ga-68]Ga-FAPI-04 PET/CT and [F-18]F-FDG PET/CT in primary and metastatic colorectal cancer lesions, and found that [Ga-68]Ga-FAPI-04 showed potential as a novel PET/CT tracer. The use of this tracer improved the staging of colorectal cancer and led to optimization or adjustment of treatment decisions.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Boon Fei Tan, Wei Chang Colin Tan, Fu Qiang Wang, Matt Lechner, Volker Hans Schartinger, Daniel Shao Weng Tan, Kelvin Siu Hoong Loke, Wen Long Nei
Summary: This systematic review explores the potential role of PSMA PET imaging and therapy as a theranostic tool for adenoid cystic carcinoma (ACC) and other salivary gland cancers (SGCs). Despite a limited number of studies, PSMA PET shows promising prospects in detecting lesions in ACC and SGC that are not detected on standard imaging. Further research is needed to guide its real-world use.
Article
Chemistry, Multidisciplinary
Cheng Wang, Zhoumi Hu, Fan Ding, Haitao Zhao, Fuqiang Du, Chun Lv, Lianghua Li, Gang Huang, Jianjun Liu
Summary: This study reported the synthesis and evaluation of two C-11-labeled FAP inhibitors, C-11-RJ1101 and C-11-RJ1102. After radiosynthesis, these tracers showed high radiochemical yields and specific activities. Compared to the existing Ga-68-labeled fibroblast activation protein inhibitors, C-11-RJ1101 and C-11-RJ1102 exhibited significant differences in tumor uptake, metabolism, and clearance.
FRONTIERS IN CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailin Qiao, Xueting Qin, Shuai Fu, Jiazhong Ren, Jing Jia, Xinying Hu, Yuanyuan Tao, Shuanghu Yuan, Yuchun Wei
Summary: The uptake of [F-18]AlF-NOTA-FAPI-04 and [F-18]FDG imaging tracers varies in malignant and inflammatory lung lesions, with lower uptake observed in inflammatory lesions. This difference in uptake can be valuable for distinguishing between malignancy and various inflammatory findings.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Barbara Vischioni, Stefania Russo, Martino Meuli, Maria Bonora, Sara Ronchi, Rossana Ingargiola, Anna Maria Camarda, Sara Imparato, Lorenzo Preda, Mario Ciocca, Silvia Molinelli, Ester Orlandi
Summary: In ACC patients, the volume of maxilla irradiated with high dose values was closely associated with the development of ORN. These results are consistent with previously published data obtained with a different radiobiological model. Our findings may help prevent the risk of ORN in patients receiving CIRT.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Lauren E. Miller, Vivienne Au, Tara E. Mokhtari, Deborah Goss, Daniel L. Faden, Mark A. Varvares
Summary: This review discusses the advances in molecular targets for adenoid cystic carcinoma (ACC), with MYB-NFIB translocation being the most researched pathway, and other molecular targets showing limited efficacy. The ongoing investigation of molecular abnormalities underlying ACC is critical for identifying and developing novel targeted therapies.
Article
Critical Care Medicine
Penghui Yang, Qun Luo, Xinlu Wang, Qi Fang, Zhenli Fu, Jia Li, Yunxin Lai, Xiaobo Chen, Xin Xu, Xiaomin Peng, Kongzhen Hu, Xiaowei Nie, Shaoyu Liu, Jinhe Zhang, Junqi Li, Chenyou Shen, Yingying Gu, Jianping Liu, Jingyu Chen, Nanshan Zhong, Jin Su
Summary: The study investigates the potential use of FAP expression intensity as a quantitative indicator of activated fibroblast quantity in ILD lungs. Multiple experimental methods were used to test FAP expression in human primary lung fibroblasts and clinical lung specimens. FAP-targeted PET/CT imaging was applied to different types of ILD patients. The results reveal that FAP expression is significantly upregulated in the early phase of fibroblast activation in response to profibrotic cytokine, and is closely correlated with fibroblastic foci abundance in ILD patient lung biopsies. Additionally, FAP detection is associated with fibrotic activity in ILDs and may aid in early diagnosis and therapeutic window selection.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunxia Qin, Yangmeihui Song, Yongkang Gai, Weiwei Ruan, Qingyao Liu, Fang Liu, Danzha Zheng, Peng Zhang, Hongli Liu, Tao Zhang, Kaixiong Tao, Xiaoli Lan
Summary: The study aims to evaluate the diagnostic efficiency of Ga-68-FAPI PET in gastrointestinal cancer and determine its potential impact on clinical management. The results show that Ga-68-FAPI PET has higher diagnostic accuracy compared to conventional imaging and F-18-FDG PET, and can provide more accurate staging and guidance for treatment revision.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yu Liu, Haocheng Tang, Tianchi Song, Mengxin Xu, Junyi Chen, Xi-Yang Cui, Yuxiang Han, Zhu Li, Zhibo Liu
Summary: In this study, the use of alpha-emitter Bi-213 and FAP inhibitors with an organotrifluoroborate linker led to improved tumor uptake, reduced side effects, and significant suppression of tumor growth.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Xueting Qin, Shijie Wang, Xiaoli Liu, Jinghao Duan, Kai Cheng, Zhengshuai Mu, Jing Jia, Yuchun Wei, Shuanghu Yuan
Summary: In this study, the diagnostic value of a novel PET/CT imaging tracer, F-18-NOTA-FAPI, in a radiation induced lung damage (RILD) rat model was explored. F-18-NOTA-FAPI showed potential as a noninvasive imaging method for RILD, which could be beneficial for clinical management of radiotherapy patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kun Liu, Yong Shi, Lili Qiao, Guodong Deng, Ning Liang, Jian Xie
Summary: This study found that cervical ABC patients had a better survival time than cervical ACC patients. Increased age was potentially an independent risk factor for poor prognosis, surgical patients had a better prognosis, and radiotherapy, or chemotherapy combination treatment had an unfavorable tendency to prognosis.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthias Lang, Anna-Maria Spektor, Thomas Hielscher, Jorge Hoppner, Frederik M. Glatting, Felix Bicu, Thilo Hackert, Ulrike Heger, Thomas Pausch, Ewgenija Gutjahr, Hendrik Rathke, Frederik L. Giesel, Clemens Kratochwil, Christine Tjaden, Uwe Haberkorn, Manuel Roehrich
Summary: Pancreatic ductal adenocarcinoma (PDAC) can arise from intraductal papillary mucinous neoplasms (IPMN) with malignant transformation. However, current nonoperative differentiation methods for benign IPMN and IPMN lesions undergoing malignant transformation are unsatisfactory. This study evaluated the clinical feasibility of using Ga-68-FAPI PET for the differentiation of menacing and low-grade IPMN, and found that Ga-68-FAPI PET showed high sensitivity and specificity in distinguishing between these subtypes.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Editorial Material
Oncology
Masayuki Tanaka, Max Heckler, Andre L. Mihaljevic, Shigenori Ei, Ulla Klaiber, Ulrike Heger, Markus W. Buechler, Thilo Hackert
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Masayuki Tanaka, Max Heckler, Andre L. Mihaljevic, Shigenori Ei, Ulla Klaiber, Ulrike Heger, Markus W. Buechler, Thilo Hackert
Summary: This study investigated the predictive factors for the prognosis of patients with resected locally advanced pancreatic cancer (LAPC) after FOLFIRINOX. Tumor shrinkage, tumor density, and postchemotherapy CA19-9 serum levels were found to be independently associated with overall survival. A simple scoring model incorporating these factors can identify patients who may benefit from additional treatment.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Martin Mynarek, Denise Obrecht, Martin Sill, Dominik Sturm, Katja Kloth-Stachnau, Florian Selt, Jonas Ecker, Katja von Hoff, Bjoern-Ole Juhnke, Tobias Goschzik, Torsten Pietsch, Michael Bockmayr, Marcel Kool, Andreas von Deimling, Olaf Witt, Ulrich Schuller, Martin Benesch, Nicolas U. Gerber, Felix Sahm, David T. W. Jones, Andrey Korshunov, Stefan M. Pfister, Stefan Rutkowski, Till Milde
Summary: This study investigates the integration of clinical and molecular parameters to improve risk stratification of non-WNT/non-SHH medulloblastoma (MB). The combination of subgroup and whole-chromosomal aberration (WCA) phenotype was found to be the best predictor of disease progression and death. The identification of low-risk and very high-risk strata through the integration of clinical and molecular variables may improve future treatment stratification.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Michaela-Kristina Keck, Martin Sill, Andrea Wittmann, Piyush Joshi, Damian Stichel, Pengbo Beck, Konstantin Okonechnikow, Philipp Sievers, Annika K. Wefers, Federico Roncaroli, Shivaram Avula, Martin G. McCabe, James T. Hayden, Pieter Wesseling, Ingrid Ora, Monica Nister, Mariette E. G. Kranendonk, Bastiaan B. J. Tops, Michal Zapotocky, Josef Zamecnik, Alexandre Vasiljevic, Tanguy Fenouil, David Meyronet, Katja von Hoff, Ulrich Schuller, Hugues Loiseau, Dominique Figarella-Branger, Christof M. Kramm, Dominik Sturm, David Scheie, Tuomas Rauramaa, Jouni Pesola, Johannes Gojo, Christine Haberler, Sebastian Brandner, Tom Jacques, Alexandra Sexton Oates, Richard Saffery, Ewa Koscielniak, Suzanne J. Baker, Stephen Yip, Matija Snuderl, Nasir Ud Din, David Samuel, Kathrin Schramm, Mirjam Blattner-Johnson, Florian Selt, Jonas Ecker, Till Milde, Andreas von Deimling, Andrey Korshunov, Arie Perry, Stefan M. Pfister, Felix Sahm, David A. Solomon, David T. W. Jones
Summary: Pediatric central nervous system (CNS) tumors are the leading cause of cancer-related death in children aged 0-14 years. A newly identified CNS tumor type characterized by PLAGL1/2 amplification and a lack of recurrent genetic alterations has been described. These tumors are composed of primitive embryonal-like cells and are associated with intermediate survival, but the cell of origin and optimal treatment strategies are yet to be determined.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Thomas Hielscher, Martin Sill, Philipp Sievers, Damian Stichel, Sebastian Brandner, David T. W. Jones, Andreas von Deimling, Felix Sahm, Sybren L. N. Maas
Summary: Risk prediction for meningioma tumors has traditionally relied on morphological features, but incorporating molecular features improves accuracy. This study confirms the practicality of using a newer brain tumor classifier and suggests that additional testing for certain mutations may not be necessary when calculating risk scores for individual patients.
Article
Oncology
Jonas Ecker, Florian Selt, Dominik Sturm, Martin Sill, Andrey Korshunov, Steffen Hirsch, David Capper, Nicola Dikow, Christian Sutter, Carina Mueller, Romain Sigaud, Angelika Eggert, Thorsten Simon, Tim Niehues, Andreas von Deimling, Kristian W. Pajtler, Cornelis M. van Tilburg, David T. W. Jones, Felix Sahm, Stefan M. Pfister, Olaf Witt, Till Milde
Summary: The PTT 2.0 program aims to improve diagnostic accuracy and detect actionable alterations in relapsed pediatric oncology patients, even with limited tumor material. The study utilized molecular analyses such as DNA methylation array, targeted gene panel sequencing, RNA sequencing, and immunohistochemistry to provide relevant and robust information for diagnosis and treatment decisions.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
P. Dao Trong, M. Gluszak, D. Reuss, A. von Deimling, A. Wick, L. Koenig, J. Debus, C. Herold-Mende, A. Unterberg, C. Jungk
Summary: This study analyzed elderly patients with lower-grade glioma and found that surgical resection and adjuvant treatment can achieve favorable outcomes, with comparable progression-free survival to younger patients.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Neurosciences
Konstantin Okonechnikov, Aniello Federico, Daniel Schrimpf, Philipp Sievers, Felix Sahm, Jan Koster, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
Summary: Currently, medulloblastoma can be treated successfully using risk-stratified approaches, but relapses remain a challenge. RNA sequencing was used to analyze the transcriptome profiles of primary-relapse MB pairs, revealing molecular features and potential predictive markers for survival.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Dominik Sturm, David Capper, Felipe Andreiuolo, Marco Gessi, Christian Koelsche, Annekathrin Reinhardt, Philipp Sievers, Annika K. Wefers, Azadeh Ebrahimi, Abigail K. Suwala, Gerrit H. Gielen, Martin Sill, Daniel Schrimpf, Damian Stichel, Volker Hovestadt, Bjarne Daenekas, Agata Rode, Stefan Hamelmann, Christopher Previti, Natalie Jaeger, Ivo Buchhalter, Mirjam Blattner-Johnson, Barbara C. Jones, Monika Warmuth-Metz, Brigitte Bison, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Martin Hasselblatt, Ulrich Schueller, Nicolas U. Gerber, Christine L. White, Molly K. Buntine, Kathryn Kinross, Elizabeth M. Algar, Jordan R. Hansford, Nicholas G. Gottardo, Pablo Hernaiz Driever, Astrid Gnekow, Olaf Witt, Hermann L. Mueller, Gabriele Calaminus, Gudrun Fleischhack, Uwe Kordes, Martin Mynarek, Stefan Rutkowski, Michael C. Fruehwald, Christof M. Kramm, Andreas von Deimling, Torsten Pietsch, Felix Sahm, Stefan M. Pfister, David. T. W. Jones
Summary: This study prospectively integrated DNA methylation profiling and targeted gene panel sequencing to evaluate their utility in routine neuropathology for newly diagnosed pediatric patients with CNS tumors. The integration of multi-omics improved diagnostic accuracy by refining DNA methylation classification, detecting relevant genetic alterations, and identifying cancer predisposition syndromes. Discrepancies between neuropathological classification and DNA methylation classification were particularly relevant for high-grade gliomas, and patients with lower-grade molecular profiles had improved survival.
Article
Oncology
Catena Kresbach, Matthias Dottermusch, Alicia Eckhardt, Inka Ristow, Petros Paplomatas, Lea Altendorf, Annika K. Wefers, Michael Bockmayr, Sarra Belakhoua, Ivy Tran, Lara Pohl, Sina Neyazi, Helena Bode, Said Farschtschi, Lennart Well, Reinhard E. Friedrich, David Reuss, Matija Snuderl, Christian Hagel, Victor-Felix Mautner, Ulrich Schueller
Summary: The study found that ANF with different histological morphologies exhibit distinct epigenetic similarities and cluster in proximity to benign peripheral nerve sheath tumor entities. Correlating this methylation pattern with clinical outcomes may be important for further understanding the malignant transformation mechanisms of ANF.
Article
Medicine, General & Internal
Thomas M. Pausch, Xinchun Liu, Josefine Dincher, Pietro Contin, Jiaqu Cui, Jishu Wei, Ulrike Heger, Matthias Lang, Masayuki Tanaka, Stephen Heap, Joerg Kaiser, Rosa Klotz, Pascal Probst, Yi Miao, Thilo Hackert
Summary: Middle segment-preserving pancreatectomy (MPP) is a feasible alternative to total pancreatectomy (TP) for treating multilocular diseases in the pancreatic head and tail, as it can preserve pancreatic functionality while avoiding impairments. A study analyzing MPP cases compared to TP cases found that MPP patients had better preserved pancreatic functionality, but a higher rate of POPF Grade B complications. Longer pancreatic remnants were associated with shorter hospital stays and fewer complications, while complications of endocrine functionality were linked to older patients. Long-term survival prospects after MPP were positive, except for cases with recurring malignancies and metastases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Ann-Kristin Afflerbach, Christian Rohrandt, Bjorn Brandl, Marthe Soenksen, Jurgen Hench, Stephan Frank, Daniela Boernigen, Malik Alawi, Martin Mynarek, Beate Winkler, Franz Ricklefs, Michael Synowitz, Lasse Duehrsen, Stefan Rutkowski, Annika K. Wefers, Franz-Josef Mueller, Melanie Schoof, Ulrich Schueller
Summary: The research suggests that using cfDNA from cerebrospinal fluid for Nanopore sequencing could be a promising approach for initial brain tumor diagnosis and an important tool for disease monitoring.
CLINICAL CHEMISTRY
(2023)
Correction
Biochemistry & Molecular Biology
Dominik Sturm, David Capper, Felipe Andreiuolo, Marco Gessi, Christian Koelsche, Annekathrin Reinhardt, Philipp Sievers, Annika K. Wefers, Azadeh Ebrahimi, Abigail K. Suwala, Gerrit H. Gielen, Martin Sill, Daniel Schrimpf, Damian Stichel, Volker Hovestadt, Bjarne Daenekas, Agata Rode, Stefan Hamelmann, Christopher Previti, Natalie Jaeger, Ivo Buchhalter, Mirjam Blattner-Johnson, Barbara C. Jones, Monika Warmuth-Metz, Brigitte Bison, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Martin Hasselblatt, Ulrich Schueller, Arend Koch, Nicolas U. Gerber, Christine L. White, Molly K. Buntine, Kathryn Kinross, Elizabeth M. Algar, Jordan R. Hansford, Nicholas G. Gottardo, Martin U. Schuhmann, Ulrich W. Thomale, Pablo Driever, Astrid Gnekow, Olaf Witt, Hermann L. Mueller, Gabriele Calaminus, Gudrun Fleischhack, Uwe Kordes, Martin Mynarek, Stefan Rutkowski, Michael C. Fruehwald, Christof M. Kramm, Andreas von Deimling, Torsten Pietsch, Felix Sahm, Stefan M. Pfister, David. T. W. Jones
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
