Time-Efficient Synthesis of Pyrido­[2,3-d]pyrimidinones via α-Oxoket­enes

Addition of silylated nucleophiles to α-oxoketenes

(2016) Yohan Dudognon et al.   CHEMICAL COMMUNICATIONS

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors

(2014) Ramakrishna Edupuganti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Eco-Efficient One-Pot Synthesis of Quinazoline-2,4(1H,3H)-diones at Room Temperature in Water

(2014) Xin-Chuan Tian et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

2,4-Dialkyl-8,9,10,11-tetrahydrobenzo[g]pyrimido[4,5-c]isoquinoline-1,3,7,12(2H,4H)-tetraones as new leads against Mycobacterium tuberculosis

(2014) Pieter Claes et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Induction of intrinsic apoptosis pathway in colon cancer HCT-116 cells by novel 2-substituted-5,6,7,8-tetrahydronaphthalene derivatives

(2014) Amira M. Gamal-Eldeen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyridopyrimidinone inhibitors of HIV-1 RNase H

(2014) Emile J. Velthuisen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

(2014) Edon Vitaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Activity of the MEK Inhibitor TAK-733 against Melanoma Cell Lines and Patient-Derived Tumor Explants

(2014) L. N. Micel et al.   MOLECULAR CANCER THERAPEUTICS

Divergent Chemo-, Regio-, and Diastereoselective Normal Electron-Demand Povarov-Type Reactions with α-Oxo-ketene Dienophiles

(2014) Jaime Galvez et al.   ORGANIC LETTERS

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

(2013) Michael P. Dickens et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

(2013) Kurt G. Pike et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient Synthesis of Uracil-Derived Hexa- and Tetrahydropyrido[2,3-d]pyrimidines

(2013) Nikita Tolstoluzhsky et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

(2013) Silvia Licciulli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Construction and functionalization of fused pyridine ring leading to novel compounds as potential antitubercular agents

(2012) Balakrishna Dulla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Catalyst- and Halogen-Free Regioselective Friedel-Crafts α-Ketoacylations

(2012) Kishor Mohanan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Microwave-Assisted Domino Benzannulation of α-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones

(2012) Juan-Carlos Castillo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design, synthesis and transformation of some heteroannulated 3-aminopyridines—purine isosteres with exocyclic nitrogen atom

(2012) Viktor O. Iaroshenko et al.   TETRAHEDRON

Expeditious Divergent Synthetic Approach to Polycyclic Terpene-Like Molecules

(2011) Thomas Boddaert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

(2011) Miriam Redondo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combination of Rearrangement with Metallic and Organic Catalyses - a Step- and Atom-Economical Approach to α-Spiroactones and -lactams

(2011) Thomas Boddaert et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Ionic liquid mediated one-pot synthesis of 6-aminouracils

(2011) Sunil S. Chavan et al.   GREEN CHEMISTRY

1,3-Dipolar Cycloaddition of Hydrazones with α-Oxo-ketenes: A Three-Component Stereoselective Entry to Pyrazolidinones and an Original Class of Spirooxindoles

(2011) Marc Presset et al.   ORGANIC LETTERS

Periselectivity Switch of Acylketenes in Cycloadditions with 1-Azadienes: Microwave-Assisted Diastereoselective Domino Three-Component Synthesis of α-Spiro-δ-lactams

(2010) Marc Presset et al.   ORGANIC LETTERS

6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors

(2009) Pamela Crepaldi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microwave-Assisted Domino and Multicomponent Reactions with Cyclic Acylketenes: Expeditious Syntheses of Oxazinones and Oxazindiones

(2009) Marc Presset et al.   ORGANIC LETTERS

Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3Adenosine Receptor Antagonists

(2008) Barbara Cosimelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted Wolff Rearrangement of Cyclic 2-Diazo-1,3-Diketones: An Eco-compatible Route to α-Carbonylated Cycloalkanones

(2008) Marc Presset et al.   JOURNAL OF ORGANIC CHEMISTRY