Article
Psychology, Clinical
Jennifer L. Gordon, Bethany Sander, Tory A. Eisenlohr-Moul, Laurie Sykes Tottenham
Summary: Individual sensitivity to estradiol is associated with the risk for perimenopausal depression, especially among women with no history of depression, reporting a low number of baseline stressful life events, and reporting fewer months since their last menstrual period.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Emilie Venborg, Merete Osler, Terese Sara Hoj Jorgensen
Summary: This study investigated the association between postpartum depression and depression during perimenopause. The results showed that postpartum depression is significantly associated with a higher risk of depression during the perimenopause.
Article
Endocrinology & Metabolism
Gioia M. Guerrieri, Rivka Ben Dor, Xiaobai Li, Shau-Ming Wei, Pedro E. Martinez, Lynnette K. Neiman, David R. Rubinow, Peter J. Schmidt
Summary: Research examined HPA axis function in perimenopausal women with and without depression, finding no abnormalities associated with PMD compared to women without depression.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychiatry
Chuanya Huang, Biru Luo, Jing Wang, Yiling Ao, Weijun Xiong, Shujuan Liao
Summary: This study explored the trajectories and longitudinal relationships between physical activity and depressive symptoms in Chinese perimenopausal women. The results showed that depressive symptoms worsened over time and were associated with age, monthly income, marital status, chronic disease, and negative life events. Physical activity decreased over time and was associated with educational background and monthly income. Perimenopausal women with more severe depressive symptoms tended to be less physically active, and those with less physical activity were more prone to report more severe depressive symptoms.
Article
Psychology, Multidisciplinary
Malgorzata Wlodarczyk
Summary: The study revealed a strong correlation between neuroticism and the frequency and intensity of psychological symptoms of menopause, with other personality traits showing a negative correlation with menopausal symptoms. Openness to experience did not exhibit correlation with vasomotor and somatic symptoms. Neuroticism was a significant predictor of the frequency and intensity of psychological, vasomotor, and somatic symptoms of menopause.
CURRENT PSYCHOLOGY
(2021)
Review
Medicine, General & Internal
Lifang Zheng, Zhanling Sun, Chenghao Liu, Jiamin Zhang, Yabei Jin, Huifang Jin
Summary: This study conducted a network meta-analysis to compare different acupuncture treatments for perimenopausal depression. The findings showed that warm acupuncture was more effective than other acupuncture methods and medication treatment in treating perimenopausal depression. These findings can provide evidence for choosing the best acupuncture treatment for patients.
Article
Psychology, Clinical
Shabaz Sendi, Susanne Fischer, Andrew Papadopoulos, Lucia Poon, Lena J. J. Rane, Abebaw Fekadu, Valeria Mondelli, Anthony J. J. Cleare
Summary: This study found that patients with major depressive disorder have higher cortisol levels after awakening compared to healthy controls, but this difference only exists in patients reporting childhood trauma. The results suggest that early life stress may impact the biological markers of individuals with major depressive disorder. Therefore, tailored treatments may be needed for this population.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Da Seul Kim, Hee Jun Kim, Min Kyoon Kim, Jae-Chan Jin, Doug Hyun Han, Sun Mi Kim
Summary: This study aimed to identify factors influencing menopause symptoms. The results showed that a family history of menopausal symptoms, age at menarche, number of pregnancies, history of postpartum mental illness, and other psychiatric disorders were positively associated with the severity of menopause symptoms. However, age and number of deliveries were negatively associated with the severity of menopause symptoms.
Article
Geriatrics & Gerontology
Da Seul Kim, Hee Jun Kim, Min Kyoon Kim, Jae-Chan Jin, Doug Hyun Han, Sun Mi Kim
Summary: This study aimed to identify factors influencing menopause symptoms. The results found that a family history of menopausal symptoms, late menarcheal age, a higher number of pregnancies, history of postpartum depression, postpartum psychosis, and other psychiatric disorders were positively associated with more severe menopause symptoms. On the other hand, age and number of deliveries were negatively associated with the severity of menopausal symptoms.
Article
Endocrinology & Metabolism
Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Margo Nathan, Aleta Wiley, Sybil Crawford, Hadine Joffe
Summary: Irritability is highly prevalent among mildly depressed perimenopausal women, and is associated with estradiol dynamics rather than depressive symptoms. Depression severity explains the largest portion of the variance in irritability.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Pamela Alebna, Nasim Maleki
Summary: This study provides the first systematic and quantitative examination of allostatic load in migraine patients, revealing that women with migraines are more likely to experience higher levels of allostatic load than their non-migraine counterparts during perimenopausal transition. The findings suggest the need for new interventions aimed at modifying the levels of allostatic load biomarkers to reduce the burden of the disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Xing-Yue Liu, Shu-Zhi Peng, Meng-Yun Pei, Peng Zhang
Summary: This study found that physical activity partially mediated the relationship between depression and quality of life in Chinese perimenopausal women. Suitable prevention methods and interventions for physical activity may improve the quality of life for perimenopausal women.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychology, Clinical
Kristen M. Culbert, Katharine N. Thakkar, Kelly L. Klump
Summary: This narrative review examines the theories behind the heightened risk for psychosis in midlife women and looks at the potential role of ovarian hormones. Studies indicate that the peak ages of midlife psychosis risk in women overlap with the age range of key menopausal stages, especially the perimenopausal transition. However, there is a lack of direct research on menopausal stage. Studies on ovarian hormone effects have mostly focused on earlier developmental stages and events, showing increases in psychotic symptoms during periods of lower estradiol levels. Future research is needed to fill the gaps in our knowledge.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Nanette Santoro, Cassandra Roeca, Brandilyn A. Peters, Genevieve Neal-Perry
Summary: Menopause transition is a disruptive process that can last for over a decade, affecting a majority of women with features like gradual loss of oocytes, altered responsiveness to gonadal steroids, wide hormonal fluctuations, and irregular menstrual patterns. Recognizing early signs and symptoms of the transition and being prepared to offer treatment to mitigate these symptoms is crucial for clinicians.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychology, Biological
Annie K. Griffith, Michelle M. Martel, Tory Eisenlohr-Moul, Mark T. Fillmore
Summary: Compared with men, women are more affected by alcohol, and the fluctuation of ovarian hormones and reduced inhibitory control may contribute to this vulnerability. This study found that the disinhibiting effect of alcohol increased nearly twofold during the late follicular phase, suggesting that ovarian hormone fluctuations play a role in increasing the risk of excessive alcohol use in women.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Substance Abuse
Jordan C. C. Barone, Jaclyn M. M. Ross, Anisha Nagpal, Gabriela Guzman, Erin Berenz, Raina D. D. Pang, Tory A. A. Eisenlohr-Moul
Summary: This study examines the relationship between alcohol use and drinking motives across the menstrual cycle in female psychiatric outpatients. The results show that women are more likely to drink heavily on weekends during the periovulatory and perimenstrual phases, and they are more likely to drink to cope during the perimenstrual phase. These findings highlight the predictable phases of increased high-risk alcohol use and the importance of individual assessment of cyclical changes to prevent heavy drinking during ovulation and menstruation.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Psychiatry
Beatriz Penalver Bernabe, Pauline M. Maki, Janet L. Cunningham, Tory Eisenlohr-Moul, Lisa Tussing-Humphreys, Ian M. Carroll, Samantha Meltzer-Brody, Jack A. Gilbert, Mary Kimmel
Summary: Higher stress during pregnancy is associated with negative outcomes and elevated inflammation. The gut microbiota and host immune responses provide insights into perceived stress during pregnancy. This study examined the associations between perceived stress, gut microbiota composition, and immune system activity in two cohorts of pregnant individuals. The results showed distinct taxonomical and immunological signatures related to perceived stress, suggesting the potential role of the gut microbiome and immune factors in modulating stress during pregnancy.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Tory A. Eisenlohr-Moul, Savannah M. Bowers, Mitchell J. Prinstein, Katja M. Schmalenberger, Erin C. Walsh, Steven L. Young, David R. Rubinow, Susan S. Girdler
Summary: Female suicide attempts peak peri-menstrually, potentially due to withdrawal of estradiol and progesterone. Experimental administration of these hormones can reduce perimenstrual exacerbation of suicidal ideation and related symptoms, while delayed withdrawal leads to symptom relapse.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Ashley G. Eng, Jenny M. Phan, Elizabeth A. Shirtcliff, Tory A. Eisenlohr-Moul, Patrick K. Goh, Michelle M. Martel
Summary: The reproductive neuroendocrine system may explain why some ADHD youths experience worsened symptoms during adolescence. This study found that males with ADHD had higher levels of hyperactivity, impulsivity, and inattention, while females had higher levels of impairment. As youth aged, hyperactivity and impulsivity declined, while impairment and depressive symptoms increased, especially amongst those at later pubertal stages.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2023)
Article
Urology & Nephrology
Jeff Kiesner, Celeste Bittoni, Tory Eisenlohr-Moul, Barry Komisaruk, Massimiliano Pastore
Summary: This study aims to examine the association between the menstrual cycle and changes in sexual desire, taking into account psychological and physical changes. Analysis of daily reports from 213 female university students over 2 menstrual cycles showed individual differences in how the menstrual cycle influences sexual desire. Results also highlight the importance of psychological changes for predicting sexual desire.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Melissa J. M. Walsh, Kathryn Gibson, Megan Hynd, Tory A. Eisenlohr-Moul, Erin C. Walsh, Lauren Schiff, Fred Jarskog, David Lalush, Gabriel S. Dichter, Crystal E. Schiller
Summary: This clinical trial aims to investigate the neural and molecular mechanisms by which estradiol treatment improves symptoms of anhedonia and psychosis during the perimenopausal transition. The study will recruit 100 unmedicated women in the late-stage perimenopausal transition and assess clinical symptoms and neurobiological markers before and after estradiol treatment. This research will provide valuable insights into predicting, treating, and developing biomarkers for perimenopausal psychiatric symptoms.
Article
Psychology, Developmental
Elizabeth Andersen, Hannah Klusmann, Tory Eisenlohr-Moul, Kayla Baresich, Susan Girdler
Summary: Female adolescents are at increased risk of depression during puberty, and this risk continues throughout their reproductive lifespan. Hormone fluctuation is considered a key factor in the development of mood disorders tied to reproductive events, but its effects on affective state change during puberty are not well understood. This study investigated the impact of recent stressful life events on the relationship between hormone change and affective symptoms in peripubertal females. The results showed that stressful life events near the pubertal transition influenced the effects of hormone change on affective symptoms, with greater symptoms associated with hormone increases in a high stress context and hormone decreases in a low stress context. These findings suggest that stress-related hormone sensitivity may contribute to the development of affective symptoms during peripubertal hormone flux.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
Editorial Material
Neurosciences
Tory A. Eisenlohr-Moul, Jordan C. Barone
BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Tory Eisenlohr-Moul, Danielle A. Swales, David R. Rubinow, Lauren Schiff, Crystal E. Schiller
Summary: The hormonal changes during pregnancy and childbirth can affect a person's emotional state, especially for those with a history of postpartum depression. This study aimed to understand how hormone-sensitive individuals can be differentiated from hormone-insensitive controls and which symptoms show the most rapid and consistent response. The results showed that hormone-sensitive participants could be distinguished from controls early on in the study, with symptoms such as anger/irritability, mood swings, and fatigue showing the most significant changes within the first week of hormone manipulation. This study highlights the importance of reproductive hormones in perinatal affective disorders and suggests that anger and irritability may be early indicators of hormone sensitivity.
NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Jordan Barone, Jessica Peters, Tory Eisenlohr-Moul
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Jordan Barone, A. Leslie Morrow, David Rubinow, Susan Girdler, Tory Eisenlohr-Moul
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Shadi Beshai, Sandeep Mishra, Justin R. Feeney, Tansi Summerfield, Chet C. Hembroff, Gregory P. Kratzig
Summary: Public safety personnel face increased risk of depression and anxiety, and trainees may be particularly susceptible to the damaging effects of envy. However, dispositional mindfulness and self-compassion can act as buffers against these negative mental health outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Meeting Abstract
Neurosciences
Jordan Barone, Tory Eisenlohr-Moul
BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Amanda Wuth, Sandeep Mishra, Shadi Beshai, Justin Feeney
Summary: The study found that unpredictable and harsh childhood environments were associated with more maladaptive schemas and cognitive distortions, and fewer positive schemas. Path analyses indicated that a model of unpredictable and harsh environments leading to maladaptive schemas and cognitive distortions had excellent statistical fit.
CURRENT PSYCHOLOGY
(2022)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)