Short-term treatment of golden retriever muscular dystrophy (GRMD) dogs with rAAVrh74.MHCK7.GALGT2 induces muscle glycosylation and utrophin expression but has no significant effect on muscle strength

Gene therapies in canine models for Duchenne muscular dystrophy

(2019) Peter P. Nghiem et al.   HUMAN GENETICS

Laminin-111 protein therapy enhances muscle regeneration and repair in the GRMD dog model of Duchenne Muscular Dystrophy

(2019) Pamela Barraza-Flores et al.   HUMAN MOLECULAR GENETICS

Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models

(2019) Yafeng Song et al.   NATURE MEDICINE

rAAVrh74.MCK.GALGT2 Demonstrates Safety and Widespread Muscle Glycosylation after Intravenous Delivery in C57BL/6J Mice

(2019) Deborah A. Zygmunt et al.   Molecular Therapy-Methods & Clinical Development

An Isolated Limb Infusion Method Allows for Broad Distribution of rAAVrh74.MCK. GALGT2 to Leg Skeletal Muscles in the Rhesus Macaque

(2018) Rui Xu et al.   Molecular Therapy-Methods & Clinical Development

Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone

(2017) Megan L. Cramer et al.   HUMAN GENE THERAPY

A Quick Reference on Hypercalcemia

(2017) Joao Felipe de Brito Galvão et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy

(2017) Caroline Le Guiner et al.   Nature Communications

The golden retriever model of Duchenne muscular dystrophy

(2017) Joe N. Kornegay   Skeletal Muscle

B4GALNT2 (GALGT2) Gene Therapy Reduces Skeletal Muscle Pathology in the FKRP P448L Mouse Model of Limb Girdle Muscular Dystrophy 2I

(2016) Paul J. Thomas et al.   AMERICAN JOURNAL OF PATHOLOGY

Use of the six-minute walk test to characterize golden retriever muscular dystrophy

(2016) Austin R. Acosta et al.   NEUROMUSCULAR DISORDERS

Deletion of Galgt2 (B4Galnt2) Reduces Muscle Growth in Response to Acute Injury and Increases Muscle Inflammation and Pathology in Dystrophin-Deficient Mice

(2015) Rui Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Modifier genes and their effect on Duchenne muscular dystrophy

(2015) Andy H. Vo et al.   CURRENT OPINION IN NEUROLOGY

Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy

(2015) J. W. McGreevy et al.   Disease Models & Mechanisms

Feasibility and Reproducibility of Echocardiographic Measures in Children with Muscular Dystrophies

(2015) Christopher F. Spurney et al.   JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Forelimb Treatment in a Large Cohort of Dystrophic Dogs Supports Delivery of a Recombinant AAV for Exon Skipping in Duchenne Patients

(2014) Caroline Le Guiner et al.   MOLECULAR THERAPY

A Comparative Study of N-glycolylneuraminic Acid (Neu5Gc) and Cytotoxic T Cell (CT) Carbohydrate Expression in Normal and Dystrophin-Deficient Dog and Human Skeletal Muscle

(2014) Paul T. Martin et al.   PLoS One

Targeting latent TGF  release in muscular dystrophy

(2014) E. Ceco et al.   Science Translational Medicine

NBD delivery improves the disease phenotype of the golden retriever model of Duchenne muscular dystrophy

(2014) Joe N Kornegay et al.   Skeletal Muscle

Vascular Delivery of rAAVrh74.MCK.GALGT2 to the Gastrocnemius Muscle of the Rhesus Macaque Stimulates the Expression of Dystrophin and Laminin α2 Surrogates

(2013) Louis G. Chicoine et al.   MOLECULAR THERAPY

Plasmapheresis Eliminates the Negative Impact of AAV Antibodies on Microdystrophin Gene Expression Following Vascular Delivery

(2013) LG Chicoine et al.   MOLECULAR THERAPY

Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers

(2013) Marianne Raith et al.   Skeletal Muscle

Evidence-based path to newborn screening for duchenne muscular dystrophy

(2012) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Bradykinin restores left ventricular function, sarcomeric protein phosphorylation, and e/nNOS levels in dogs with Duchenne muscular dystrophy cardiomyopathy

(2012) Jin Bo Su et al.   CARDIOVASCULAR RESEARCH

Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies

(2012) Joe N. Kornegay et al.   MAMMALIAN GENOME

Successful Regional Delivery and Long-term Expression of a Dystrophin Gene in Canine Muscular Dystrophy: A Preclinical Model for Human Therapies

(2012) Zejing Wang et al.   MOLECULAR THERAPY

Long-term functional adeno-associated virus-microdystrophin expression in the dystrophic CXMDj dog

(2011) Taeyoung Koo et al.   JOURNAL OF GENE MEDICINE

Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs

(2011) Deborah M. Fine et al.   NEUROMUSCULAR DISORDERS

Immunity and AAV-Mediated Gene Therapy for Muscular Dystrophies in Large Animal Models and Human Trials

(2011) Zejing Wang et al.   Frontiers in Microbiology

Use of Simpson's Method of Disc to Detect Early Echocardiographic Changes in Doberman Pinschers with Dilated Cardiomyopathy

(2010) G. Wess et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Widespread Muscle Expression of an AAV9 Human Mini-dystrophin Vector After Intravenous Injection in Neonatal Dystrophin-deficient Dogs

(2010) Joe N Kornegay et al.   MOLECULAR THERAPY

Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs

(2010) Christopher J. Tegeler et al.   MUSCLE & NERVE

Timeline of cardiac dystrophy in 3-18-month-old MDX mice

(2010) Christel Van Erp et al.   MUSCLE & NERVE

A Human-Specific Deletion in Mouse Cmah Increases Disease Severity in the mdx Model of Duchenne Muscular Dystrophy

(2010) K. Chandrasekharan et al.   Science Translational Medicine

Overexpression of Galgt2 Reduces Dystrophic Pathology in the Skeletal Muscles of Alpha Sarcoglycan-Deficient Mice

(2009) Rui Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

The synaptic CT carbohydrate modulates binding and expression of extracellular matrix proteins in skeletal muscle: Partial dependence on utrophin

(2009) Jung Hae Yoon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Evaluation of Vascular Delivery Methodologies to Enhance rAAV6-mediated Gene Transfer to Canine Striated Musculature

(2009) Paul Gregorevic et al.   MOLECULAR THERAPY

Immune Responses to AAV in Canine Muscle Monitored by Cellular Assays and Noninvasive Imaging

(2009) Zejing Wang et al.   MOLECULAR THERAPY

Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild-type mice

(2008) Paul T. Martin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs

(2008) Yongping Yue et al.   MOLECULAR THERAPY