Evaluation of chimeric antigen receptor T cell therapy in non-human primates infected with SHIV or SIV

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques

(2018) Cristina Bergamaschi et al.   CYTOKINE

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments

(2018) Claire Deleage et al.   Retrovirology

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

(2018) Dionysios C. Watson et al.   PLoS Pathogens

Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication

(2018) Kumudhini Preethi Haran et al.   Frontiers in Immunology

Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels

(2017) James N. Kochenderfer et al.   JOURNAL OF CLINICAL ONCOLOGY

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

(2017) Anjie Zhen et al.   PLoS Pathogens

HIV-1-Specific Chimeric Antigen Receptors Based on Broadly Neutralizing Antibodies

(2016) Ayub Ali et al.   JOURNAL OF VIROLOGY

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

(2016) Rosemarie D. Mason et al.   PLoS Pathogens

IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions

(2015) Arne Sattler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

(2015) Kai Deng et al.   NATURE

Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+T cells, and disease progression

(2015) Daniel T. Claiborne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

(2013) Andrew L. Ferguson et al.   IMMUNITY

Characterization and Favorablein VivoProperties of Heterodimeric Soluble IL-15·IL-15Rα Cytokine Compared to IL-15 Monomer

(2013) Elena Chertova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating IL-15 exists as heterodimeric complex with soluble IL-15R  in human and mouse serum

(2012) C. Bergamaschi et al.   BLOOD

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

(2011) T. A. Waldmann et al.   BLOOD

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Trafficking, Persistence, and Activation State of Adoptively Transferred Allogeneic and Autologous Simian Immunodeficiency Virus-Specific CD8 + T Cell Clones during Acute and Chronic Infection of Rhesus Macaques

(2009) Diane L. Bolton et al.   JOURNAL OF IMMUNOLOGY