Journal
ORGANIC LETTERS
Volume 23, Issue 8, Pages 3070-3075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00739
Keywords
-
Categories
Funding
- Grant for Basic Science Research Projects from The Sumitomo Foundation
Ask authors/readers for more resources
Efficient dynamic kinetic resolution of cyclic halohydrins was achieved by asymmetric transfer hydrogenation of racemic alpha-haloketones using bifunctional oxo-tethered Ru(II) catalysts. The catalyst could produce chiral alcohols with various functional groups with excellent diastereo- and enantioselectivities, providing a concise synthetic approach to a dopamine D3 receptor ligand, (+)-PHNO.
A highly efficient dynamic kinetic resolution of cyclic halohydrins was achieved by the asymmetric transfer hydrogenation of racemic alpha-haloketones. Bifunctional oxo-tethered Ru(II) catalysts could promote the reduction without deterioration of halogens. By structural tuning of the catalyst, chiral alcohols having halogen, ester, carboxamide, and sulfone functions were obtained variably with excellent diastereo- and enantioselectivities (up to >99:1 d.r. and >99.9 ee), which provided a concise synthetic approach to a dopamine D3 receptor ligand, (+)-PHNO.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available