Article
Cell Biology
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia (PE) is a major cause of maternal-fetal morbidity and mortality worldwide. This research shows that placental activation of PPAR gamma can improve the secretion of angiogenic proteins and enhance endothelial function in PE.
Article
Obstetrics & Gynecology
Sunitha Suresh, Easha Patel, Ariel Mueller, Jessica Morgan, Whitney Lynn Lewandowski, Stefan Verlohren, Peter von Dadelszen, Laura A. Magee, Sarosh Rana
Summary: Hypertension complicates a significant percentage of pregnancies and is a leading cause of maternal and perinatal morbidity and mortality. This study aimed to evaluate the prognostic value of the soluble fms-like tyrosine kinase-1/placental growth factor ratio in women with suspected preeclampsia who have already met the diagnostic criteria. The findings suggest that this ratio is associated with an increased risk of developing preeclampsia with severe features.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julia Binder, Pilar Palmrich, Erkan Kalafat, Petra Pateisky, Ebru Oeztuerk, Johanna Mittelberger, Asma Khalil
Summary: This study evaluated the predictive value of the sFlt-1/PlGF ratio in women with chronic hypertension for delivery due to superimposed preeclampsia, finding that angiogenic imbalance can predict delivery related to superimposed preeclampsia and is associated with a significantly shorter time to delivery interval.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Shunping Gui, Shengping Zhou, Min Liu, Yanping Zhang, Linbo Gao, Tao Wang, Rong Zhou
Summary: In patients with severe preeclampsia (sPE), the upregulation of soluble Axl (sAxl) in maternal plasma is positively correlated with elevated levels of sFlt-1 and negatively correlated with placental NO synthase (eNOS). Elevated sAxl levels suppress proliferation and tube formation of endothelial cells, and promote cytotoxicity. The study also demonstrates that sAxl plays a role in systemic vascular injury through the regulation of key molecules of angiogenesis, contributing to the development of sPE.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Obstetrics & Gynecology
Grzegorz Szewczyk, Michal Pyzlak, Katarzyna Pankiewicz, Ewa Szczerba, Aleksandra Stangret, Dariusz Szukiewicz, Marta Skoda, Joanna Bierla, Bozena Cukrowska, Anna Fijalkowska
Summary: Impaired angiogenesis is a common finding in preeclamptic placentas, with a new angiogenetic role of fractalkine (CX3CL1) being recognized. Higher levels of CX3CL1 and sFlt-1, and lower levels of PlGF were observed in preeclampsia cases. The underdevelopment of placental vascular network in preeclampsia is associated with changes in the CX3CL1/CX3CR1 system, especially in cases complicated with fetal growth restriction (FGR).
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Bianca R. Fato, Sally Beard, Natalie K. Binder, Tu'uhevaha J. Kaitu'u-Lino, Kenji Onda, Natalie J. Hannan
Summary: The study demonstrated that both esomeprazole MH and MTH could reduce key factors associated with preeclampsia, but esomeprazole MH was more efficacious in vitro.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Developmental Biology
Victor Antonio Ferreira Freire, Anderson Dutra de Melo, Herica de Lima Santos, Melina Barros-Pinheiro
Summary: Studies on oxidative stress biomarkers have shown that there are different phenotypes between early and late preeclampsia (PE). This study aimed to review the oxidative stress profile in different subtypes of PE and identify the markers that are altered in blood and placental tissue. A literature search was conducted without restrictions on year and language of publication. After screening a total of 13,319 records, 65 studies were included in the systematic review. The results showed that oxidative stress is closely related to the pathophysiology of PE, with increased lipid peroxidation in blood and placenta, reduced levels of nitric oxide (NO) and total antioxidant capacity (TAC) in blood, as well as lower enzymatic activity of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) in PE.
Article
Multidisciplinary Sciences
Jaskiran Kaur, Kajal Kamboj, Ashok Kumar Yadav, Prabhjot Kaur, Vivek Kumar, Vivekanand Jha
Summary: Cholecalciferol supplementation has a significant effect on the levels of angiogenic markers in non-diabetic CKD patients, and also improves brachial artery flow-mediated dilatation.
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Environmental Sciences
Miaoliang Wu, Fuhui Yan, Qian Liu, Ganzhong Liao, Yilin Shen, Zhi Bai, Xiaoshan Liu
Summary: Preeclampsia (PE) is a disease that occurs after 20 weeks of pregnancy and is characterized by new onset hypertension and albuminuria or other end-organ damage. It is a major complication of pregnancy that can increase morbidity and mortality in pregnant women and fetuses, causing significant social burden. Recent research suggests that exposure to environmental xenobiotic compounds, particularly endocrine disruptors, may contribute to the development of PE. However, the specific mechanisms underlying this relationship remain unclear. This paper reviews the role and potential mechanism of PE induced by exogenous chemicals and provides an outlook on the environmental etiology of PE.
Article
Obstetrics & Gynecology
Lisa Antonia Lorenz-Meyer, Lisa Frank, Dorota Sroka, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: This study examined the correlation between serum levels of sFlt-1 and PlGF and placental weight, and found a positive relationship in preeclampsia-associated pregnancy disorders. The study results indicate that the serum sFlt-1/PlGF ratio increases with severity of the disease.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Cell Biology
Xiaotong Yang, Paula A. Benny, Elorri Cervera-Marzal, Biyu Wu, Cameron B. Lassiter, Joshua Astern, Lana X. Garmire
Summary: Variations in telomere length have been linked to aging, stress, and diseases. This study investigated the association between placental telomere length and preeclampsia. The results suggest that placental telomere length is not significantly different between severe preeclampsia cases and healthy controls, but it is negatively correlated with gestational age and influenced by race.
Article
Cell Biology
Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia
Summary: Aberrant ceramide build-up in preeclampsia leads to exuberant autophagy-mediated trophoblast cell death. Lysosome formation is markedly increased in trophoblast cells of early-onset preeclamptic placentae, accompanied by augmented levels of transcription factor EB. Ceramide-induced lysosomal biogenesis and exocytosis contribute to maternal endothelial dysfunction in preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Peng Xu, Yeling Ma, Hongyu Wu, Yan-Ling Wang
Summary: Disorders in placental cells are closely associated with adverse pregnancy outcomes, and microRNAs in the placenta play important roles in regulating placental cell behaviors. Placental exosome miRNAs can potentially target maternal cells for intercellular communication between the mother and fetus, serving as novel biomarkers for predicting diseases such as preeclampsia. The transfer of placental miRNAs through exosomes may offer targeted strategies for diagnosing, prognosing, or treating preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Allergy
Alice Zavatta, Francesca Parisi, Chiara Mando, Chiara Scaccabarozzi, Valeria M. Savasi, Irene Cetin
Summary: Inflammation and cellular senescence play a role in various physiological processes in females, including ovulation, menstruation, placental homeostasis, and delivery. Factors such as lifestyles, nutrition, environmental insults, and pregestational inflammatory diseases can lead to chronic excessive inflammation and inflammaging, resulting in decreased fertility, poor pregnancy outcomes, impaired placental function, fetal development, and increased future health risks in offspring. Maladaptation to pregnancy and obstetric diseases can contribute to maternal inflammaging, which can further accelerate aging processes and the development of chronic diseases. Maternal inflammaging can also impact future adult health through transgenerational effects. Therefore, effective interventions should be implemented to reduce modifiable factors contributing to the inflammaging process and improve public health.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Acoustics
Bronacha Mylrea-Foley, Hans Wolf, Tamara Stampalija, Christoph Lees
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Environmental Sciences
Sara Molgora, Emanuela Saita, Maurizio Barbieri Carones, Enrico Ferrazzi, Federica Facchin
Summary: Postpartum depression is a common issue for mothers worldwide and is associated with anxiety disorders and parenting stress. This study aimed to describe the psychological status of mothers up to 12 months postpartum and identify predictors of depressive symptoms at 12 months postpartum. The findings highlight the importance of stable programs for mothers in the first year postpartum, and ensuring a positive childbirth experience to reduce potential long-term consequences.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Chiara Mando, Silvio Abati, Gaia Maria Anelli, Chiara Favero, Anais Serati, Laura Dioni, Marta Zambon, Benedetta Albetti, Valentina Bollati, Irene Cetin
Summary: This study found that the epigenetic profile in the saliva of obese pregnant women is markedly different from that of normal-weight pregnant women, suggesting the presence of impaired mechanisms and damaged pathways. The characterization of this profile can serve as a promising tool for the identification of obesity-related altered mechanisms and the development of biomarkers for early diagnosis and treatment of pregnancy-adverse conditions.
Article
Nutrition & Dietetics
Fabrizia Lisso, Maddalena Massari, Micaela Gentilucci, Chiara Novielli, Silvia Corti, Leonardo Nelva Stellio, Roberta Milazzo, Ersilia Troiano, Ella Schaefer, Irene Cetin, Chiara Mando
Summary: Pregnant women in Italy do not adhere to nutritional recommendations during pregnancy, with lower caloric intake, excess protein and sugar intake, and inadequate intake of micronutrients.
Article
Nutrition & Dietetics
Daniela Denis Di Martino, Laura Avagliano, Enrico Ferrazzi, Federica Fuse, Vittoria Sterpi, Marco Parasiliti, Tamara Stampalija, Sara Zullino, Antonio Farina, Gaetano Pietro Bulfamante, Matteo Di Maso, Francesco D'Ambrosi
Summary: This study found a higher prevalence of placental maternal vascular malperfusion in HDP-FGR and early FGR groups, which were associated with abnormal feto-placental Doppler parameters. In contrast, HDP-AGA fetus and late FGR presented more heterogeneous placental lesions not severe enough to cause feto-placental Doppler anomalies. These findings suggest potential preventive nutritional approaches for pregnant women with predisposing factors for HDP-AGA fetuses and late FGR.
Article
Nutrition & Dietetics
Daniela Di Martino, Mattia Cappelletti, Marta Tondo, Katia Basello, Camilla Garbin, Attilio Speciani, Enrico Ferrazzi
Summary: This study investigated the impact of SARS-CoV-2 infection on pregnant women and its relationship with overweight, obesity, and gestational diabetes. The findings showed that infected individuals had higher levels of advanced glycation end-products and glycated albumin, leading to premature delivery and impaired fetal growth.
Article
Obstetrics & Gynecology
Luz Maria Vilca, Valentina Sala, Antonio Chiantera, Nicola Colacurci, Irene Cetin
Summary: This study assessed the characteristics and integration of immunization services into prenatal care provided by maternity care units (MCUs) in Italy. The findings showed that most MCUs provided vaccine information, but only 22% had an onsite vaccination clinic. Less than half of the MCUs offered vaccines during prenatal visits, and 75% of them required women to set up an extra appointment for vaccination. Additionally, only 20% of MCUs managed to record vaccines in their own medical records. Institutional barriers and lack of certain vaccine-related services were identified as the main reasons for missed vaccination opportunities. Embedding maternal immunization programs within prenatal care services could improve vaccine coverage.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Microbiology
Sara Ornaghi, Alice Maraschini, Marta Buoncristiano, Edoardo Corsi Decenti, Elisabetta Colciago, Irene Cetin, Serena Donati
Summary: Italy conducted a population-based study on maternal sepsis occurring before or after childbirth. The study found an incidence rate of 5.5 per 10,000 maternities. Genital, respiratory, and urinary tract infections were the predominant sources of infection, mainly caused by E. coli and polymicrobial infections. It is important to raise awareness of maternal sepsis and its risk factors and management.
Article
Biochemistry & Molecular Biology
Daniela Denis Di Martino, Chiara Maria Soldavini, Gabriele Rossi, Maria Chiara Lonardoni, Gabriele Tine, Agnese Caneschi, Francesco D'Ambrosi, Enrico Ferrazzi
Summary: This study aimed to evaluate the sFlt-1/PlGF ratio in pregnancies complicated by COVID-19 and gestational diabetes (GD) and found that patients with both GD and SARS-CoV-2 infection had a higher sFlt-1/PlGF ratio, along with a higher incidence of obesity and hypertensive disorders of pregnancy.
Review
Acoustics
Moira Barbieri, Daniela Denis Di Martino, Enrico Mario Ferrazzi, Tamara Stampalija
Summary: Placental blood supply to the fetus can be measured by evaluating the umbilical vein blood flow. Despite its potential application in healthcare, the umbilical vein blood flow volume is still used only in research setting. One of the reasons is a concern regarding its reproducibility, partly due to technology issues. Nowadays, technology improvements make this evaluation accurate and reproducible. The aim of this review is to refresh basic elements of the physiology of umbilical vein blood flow and its analysis. Its evaluation in normal and abnormal fetal growth is also discussed.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Review
Medicine, General & Internal
Moira Barbieri, Giulia Zamagni, Ilaria Fantasia, Lorenzo Monasta, Leila Lo Bello, Mariachiara Quadrifoglio, Giuseppe Ricci, Gianpaolo Maso, Monica Piccoli, Daniela Denis Di Martino, Enrico Mario Ferrazzi, Tamara Stampalija
Summary: The objectives of this study were to review the available umbilical vein blood flow volume (UV-Q) reference ranges in uncomplicated pregnancies and compare them with UV-Q values obtained from a local cohort. Literature in English was reviewed according to PRISMA guidelines. Original articles were grouped based on UV sampling sites and formulae used to compute UV-Q. The UV-Q values were derived from formulae or tables presented by authors. A prospective observational study of uncomplicated singleton pregnancies was conducted to compare UV-Q with the systematic review results. Overall, there was a substantial heterogeneity in reported UV-Q central values, but values overlapped when using the same sampling methodology and formulae. The study suggests that UV-Q assessment is accurate and reproducible when adhering to the same methodology, encouraging further investigation on clinical applications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Anais Serati, Chiara Novielli, Gaia Maria Anelli, Maria Mandalari, Francesca Parisi, Irene Cetin, Renata Paleari, Chiara Mando
Summary: Maternal obesity and gestational diabetes mellitus (GDM) are associated with adverse maternal and foetal outcomes, and involve epigenetic alterations contributing to the pathogenesis of metabolic diseases. This pilot study analyzed plasma microRNAs in obese pregnant women with/without GDM, revealing differentially expressed microRNAs related to oxidative stress, inflammation, nutrients, and hormones metabolism. These findings provide insight into the complex epigenetic network regulating metabolic pathways in MO and GDM, but further investigations are needed.
Article
Health Care Sciences & Services
Chiara Lubrano, Alessandro Mancon, Gaia Maria Anelli, Gloria Gagliardi, Roberta Corneo, Micol Bianchi, Chiara Coco, Giulia Dal Molin, Michele Vignali, Irene Schirripa, Nicoletta Di Simone, Giulia Pavone, Antonio Pellegrino, Maria Rita Gismondo, Valeria Maria Savasi, Irene Cetin
Summary: COVID-19 infection is associated with increased risk of pregnancy complications, highlighting the importance of vaccination during pregnancy. This study evaluated the humoral and cell-mediated responses to SARS-CoV-2 immunization in maternal and neonatal plasma. The results showed that most vaccinated pregnant women produced positive anti-S antibodies and had effective placental transfer, but the evaluation of IFN-γ production was inconclusive.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Stefano Faiola, Maria Mandalari, Chiara Coco, Daniela Casati, Arianna Laoreti, Savina Mannarino, Carla Corti, Dario Consonni, Irene Cetin, Mariano Lanna
Summary: This study aimed to evaluate the long-term cardiological outcomes of prenatal RVOTAs in monochorionic diamniotic twin pregnancies complicated by TTTS and treated with FLS. The majority of these pregnancies still had CHD at long-term follow-up. The risk of major CHD increased with prenatal evidence of PS and decreased with the gestational age at the time of TTTS and with the prenatal normalization of blood flow across the pulmonary valve.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)