Journal
ORGANIC LETTERS
Volume 23, Issue 10, Pages 3818-3822Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.1c00835
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Funding
- National Key Research and Development Program [2018YFA0903300]
- National Natural Science Foundation of China [21772125, 21922106, 81803359]
- West China Hospital of Sichuan University
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A general and mild approach for preparing alpha-branched aliphatic amines from imines is reported here. This method utilizes a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest a radical pathway for this transformation.
Here we report a general and mild approach to prepare alpha-branched aliphatic amines from imines. This method capitalizes on a cobalt-catalyzed umpolung alkylation of imines, employs easily available reaction partners, and demonstrates a broad substrate scope. Mechanistic studies suggest this transformation occurs by a radical pathway.
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