Article
Pharmacology & Pharmacy
Romain Brusini, Julien Iehl, Elodie Clerc, Melanie Gallet, Francois Bourdon, Jimmy Faivre
Summary: This study compared the influence of lidocaine and mepivacaine on fillers and found that they had similar effects, making both suitable as anesthetics for soft-tissue fillers.
Review
Biochemistry & Molecular Biology
Salvatore Piero Fundaro, Giovanni Salti, Dennis Malvin Hernandez Malgapo, Silvia Innocenti
Summary: This review describes the rheological properties of hyaluronic acid (HA) fillers, aiming to help clinicians understand their characteristics and their likely correlation with clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Stefano Pluda, Cecilia Salvagnini, Anna Fontana, Anna Marchetti, Alba Di Lucia, Devis Galesso, Cristian Guarise
Summary: This study investigates the modulation of hyaluronic acid dermal filler properties, particularly rheology, through process parameters such as modification degree, concentration, and molecular weight. The characterization of commercial hyaluronic acid injectables provides insights into their clinical effects and correlations with in vitro parameters. The findings emphasize the impact of hydrogel composition, rheological properties, and needle size on injectability and fibroblast recognition.
Article
Biochemistry & Molecular Biology
Wim H. De Jong, Danyel Jennen, Peter H. J. Keizers, Hennie M. Hodemaekers, Jolanda P. Vermeulen, Frank Bakker, Paul Schwillens, Marcel van Herwijnen, Marlon Jetten, Jos C. S. Kleinjans, Robert E. Geertsma, Rob J. Vandebriel
Summary: Research has revealed that a higher degree of cross-linking in hyaluronic acid fillers may not necessarily lead to more severe adverse effects. Monitoring cytokine induction and gene expression in macrophages can provide a predictive method for biomaterial-induced responses in patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Surgery
Yolanda Salinas-Alvarez, Alejandro Quiroga-Garza, Adolfo Soto-Dominguez, Arnulfo Villanueva-Olivo, Roberto Montes-de-Oca-Luna, Sandra Sabrina Rojo-Garza, Guillermo Jacobo-Baca, Santos Guzman-Lopez, Rodrigo Enrique Elizondo-Omana
Summary: This review discusses the use of animal models in evaluating the properties, characteristics, and treatments of HA fillers. Rats are commonly used to study the properties and degradation of HA fillers, while rabbits are preferred for evaluating HA embolism treatments. Mice and rats are challenging for vascular occlusion models due to vessel size and filler viscosity.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Dermatology
Leonie W. Schelke, Peter Velthuis, Jonathan Kadouch, Arthur Swift
Summary: Using duplex ultrasonography and injection of hyaluronidase can improve the treatment outcome after a vascular adverse event with hyaluronic acid filler treatments.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Surgery
Ayaka Nishikawa, Yoshiyuki Aikawa, Taro Kono
Summary: This study retrospectively observed that early complications of hyaluronic acid filler injection mainly included vascular compromise, with the most common site being the nasolabial fold. To avoid these early complications, injectors need to have good anatomical knowledge and experience with hyaluronic acid fillers, and follow guidelines strictly.
AESTHETIC SURGERY JOURNAL
(2023)
Editorial Material
Dermatology
Khalifa Al-Ghanim, Robert Richards, Steven Cohen
Summary: The study aims to create clinical charts for filler selection, injection, and addressing complications. A numerical and color-coded chart based on G-prime, as well as an anatomical table and safety table, were created using literature and expert opinions. Fillers play a significant role in achieving favorable results, and their selection in different anatomical planes is crucial.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Polymer Science
Giuseppe Alonci, Anna Boussard, Martina Savona, Fabiana Cordella, Gaetano Angelici, Roberto Mocchi, Sabrina Sommatis, Damiano Monticelli
Summary: Hyaluronic acid is an important ingredient in dermal fillers that is often cross-linked to improve properties and durability. Poly(ethylene glycol) diglycidyl ether (PEGDE) has been introduced as a crosslinker with similar chemical reactivity as the commonly used crosslinker BDDE. However, there are no literature methods available to monitor PEGDE content. This study presents an HPLC-QTOF method for routine examination of PEGDE content in HA hydrogels, following the guidelines of the International Council on Harmonization.
Review
Dermatology
Ploymanee Wongprasert, Cecile A. Dreiss, Gillian Murray
Summary: Soft-tissue augmentation using hyaluronic acid-based dermal fillers is a popular non-surgical treatment for restoring volume loss and filling fine lines. This article reviews the methods and parameters used to characterize dermal fillers, providing a useful guide for clinicians and injectors in selecting the optimal product for each patient.
DERMATOLOGIC THERAPY
(2022)
Review
Surgery
Yiwen Huang, Yibin Zhang, Xiaojing Fei, Qi Fan, Jie Mao
Summary: This meta-analysis compared the efficacy and safety of monophasic and biphasic hyaluronic acid (HA) fillers for esthetic nasolabial folds (NLFs) correction. The results showed that monophasic fillers had a significantly higher improvement in NLF severity scores compared to biphasic fillers. This effect was consistent regardless of ethnicity, total injection volume, and baseline NLF severity. Furthermore, more subjects preferred monophasic fillers and reported a lower rate of post-injection pain.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Dermatology
Joon Min Jung, Woo Shun Lee, Jihae Yoon, Seung Hwan Paik, Hye Sung Han, Woo Jin Lee, Sung Eun Chang, Chong Hyun Won, Beom Joon Kim
Summary: This study compared the long-term effectiveness and safety of Neuramis Volume Lidocaine and Juvederm Voluma with Lidocaine in mid-face volume restoration in Asians, showing comparable longevity and safety over 2 years. Both fillers had durable effects for up to 2 years with minimal safety concerns in mid-face volume restoration.
DERMATOLOGIC THERAPY
(2021)
Article
Dermatology
Agnieszka Owczarczyk-Saczonek, Koenraad De Boulle
Summary: There has been a continuous increase in the popularity of esthetic procedures using substances like hyaluronic acid (HA) in recent years, which has resulted in a rise in the number of adverse events. This article presents a case-series study of patients who developed ASIA syndrome following HA injection after a delayed inflammatory reaction (DIR), highlighting the importance of long-term monitoring for such reactions.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danyel G. J. Jennen, Marcel van Herwijnen, Marlon Jetten, Rob J. Vandebriel, Peter Keizers, Robert E. Geertsma, Wim H. de Jong, Jos C. S. Kleinjans
Summary: The use of injectable dermal fillers for aesthetic purposes has increased significantly in recent years, leading to a rise in related adverse reactions. A study on gene expression changes in a human 3D skin model exposed to different hyaluronic acid fillers revealed elevated expression of cytokines and chemokines related to acute inflammation, as well as down-regulation of genes related to mitochondrial dysfunction. The study suggests that fillers may induce inflammatory and fibrotic responses, highlighting the importance of understanding the biological responses induced by these products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Wioletta Baranska-Rybak, Magdalena Antoszewska
Summary: The study evaluated the efficacy of HA dermal filler injections combined with personally prepared skincare formulations on skin conditions affected by aging. Results showed promising outcomes in addressing various skin dysfunctions, such as loss of elasticity, hyperpigmentation, erythema, and hyperseborrhea. The combination therapy of HA fillers and personalized skincare products demonstrated overall satisfaction among participants.
DERMATOLOGIC THERAPY
(2021)
Article
Ophthalmology
Jane S. Kim, Leon Rafailov, Ilya M. Leyngold
Summary: Corneal neurotization is effective in improving corneal sensation and promoting corneal healing in patients with postherpetic neurotrophic keratopathy. Additionally, it can enhance visual acuity in these patients.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Letter
Dermatology
Roshni U. Ranjit-Reeves, Atalie C. Thompson, Leon Rafailov, Jane S. Kim, Julie A. Woodward
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2021)
Article
Ophthalmology
Jane S. Kim, Anna Ginter, Roshni Ranjit-Reeves, Julie A. Woodward
Summary: Ablative carbon dioxide laser resurfacing of the lower eyelids can provide excellent aesthetic results with high patient satisfaction and low complication rates. Timely and proper management of postoperative complications is essential for maximizing successful cosmetic outcomes.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Review
Clinical Neurology
Jane S. Kim, Jason Liss
Summary: Lesions of the lacrimal gland can be caused by various factors, including inflammatory and lymphoproliferative disorders, benign and malignant epithelial tumors. Benign tumors are usually unilateral, while a rapid onset of symptoms and periorbital pain may indicate malignant disease. A good understanding of common clinical characteristics and radiographic imaging findings is essential for diagnosis and treatment.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2021)
Article
Ophthalmology
Leon Rafailov, Jane S. Kim, Clayton Ellis Wisely, Edgar M. Espana, Matias Soifer, Ilya M. Leyngold
Summary: Corneal neurotization (CN) provides improvement in corneal health and sensibility, with high patient satisfaction and minimal postoperative pain and morbidity.
Article
Ophthalmology
Jane S. Kim, Alan D. Proia, Jason Liss, Joel Morgenlander, Landon C. Meekins
Summary: Primary ductal adenocarcinoma of the lacrimal gland is a rare and aggressive malignancy that presents with symptoms such as proptosis, pain, and vision problems. In rare cases, it may first present with multiple cranial neuropathies. A targeted diagnostic evaluation involving clinical history, examination, and neuroimaging, as well as repeat biopsy or complete excision of the lacrimal gland, may be necessary for accurate diagnosis.
OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Shoaib Ugradar, Jane S. Kim, Noelle Trost, Emanuil Parunakian, Erin Zimmerman, Kambiz Ameli, Marissa K. Shoji, Wendy W. Lee
Summary: This study assessed the effects of oxymetazoline hydrochloride 0.1% ophthalmic solution on upper and lower eyelid position, brow position, and sclera color in patients with ptosis. The results showed that within 2 hours of treatment, oxymetazoline significantly improved eyelid aperture size and made the eyes appear whiter.
AESTHETIC SURGERY JOURNAL
(2022)
Editorial Material
Ophthalmology
Jane S. Kim, Jonathan D. Trobe, Shannon S. Joseph
Summary: A woman in her 60s with a history of hyperlipidemia, hypothyroidism, and chronic migraines presented with progressively worsening left-sided ptosis. Examination revealed mild fullness in the left superior sulcus and mildly increased left-sided resistance to retropulsion. What would you do next?
JAMA OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Cynthia A. Boxrud, Nicholas A. Householder, Dylan K. Kim, Katherine M. Kugler, Chandler S. Harris, Brooke P. Benjamin, Alexa H. Panrudkevich, Gavin G. Bahadur
Summary: Face mask-wearing practices have an impact on the visual field, especially during the COVID-19 pandemic. This study examined the visual field of 10 participants using different types of masks and found that wearing duckbill N95 masks was associated with increased errors in the lower visual field compared to wearing surgical masks or no masks. These findings support the previous guidance on the risks of falls and accidents related to face mask wearing.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Orthopedics
Nicholas A. Householder, Akshay Raghuram, Kofi Agyare, Skyler Thipaphay, Mimi Zumwalt
Summary: This article reviews the current research on experimental injections aimed at achieving cellular restoration of the hyaline cartilage tissue of the knee joint. The most promising intra-articular injections for the treatment of primary osteoarthritis include bioengineered advanced-delivery steroid-hydrogel preparations, ex vivo expanded allogeneic stem cell injections, genetically engineered chondrocyte injections, recombinant fibroblast growth factor therapy, injections of selective proteinase inhibitors, senolytic therapy via injections, injectable antioxidant therapies, injections of Wnt pathway inhibitors, injections of nuclear factor-kappa beta inhibitors, injections of modified human angiopoietin-like-3, various potential viral vector-based genetic therapy approaches, and RNA genetic technology administered via injections.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Ophthalmology
Bradford W. Lee, Jane S. Kim, Richard L. Scawn, Bobby S. Korn, Don O. Kikkawa
Summary: This study retrospectively analyzed the effects of removal of the lateral orbital rim in patients with residual symptomatic proptosis after three-wall decompression for thyroid eye disease. The results showed that removal of the lateral orbital rim can effectively reduce the degree of proptosis without significant complications.
TAIWAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jane S. Kim, Amal Al-Lozi, Ilya M. Leyngold
Summary: Malignant orbital masses can be caused by a variety of pathologies, including primary tumors, mesenchymal tumors, optic nerve tumors, lymphoproliferative disorders, and secondary tumors. Clinical knowledge and imaging findings are necessary to make a correct diagnosis and provide appropriate treatment. Treatment plans should be determined based on clinical stage and histological grade of the tumor.
CURRENT OPHTHALMOLOGY REPORTS
(2021)
