Article
Obstetrics & Gynecology
Vivian Wai Yan Ng, Mimi Tin Yan Seto, Holly Lewis, Ka Wang Cheung
Summary: This study evaluated the effectiveness of quantitative fetal fibronectin (fFN) concentration in predicting spontaneous preterm birth (PTB) in symptomatic women in Hong Kong. The findings suggest that fFN concentration can predict the risk of PTB and help clinicians rule out preterm birth and reduce unnecessary interventions and hospitalization.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Health Care Sciences & Services
Delia Grab, Bogdan Doroftei, Mihaela Grigore, Ovidiu Sebastian Nicolaiciuc, Sorana Caterina Anton, Gabriela Simionescu, Radu Maftei, Maria Bolota, Ciprian Ilea, Gabriel Costachescu, Emil Anton
Summary: Qualitative fetal fibronectin testing and transvaginal cervical length measurement are useful in predicting spontaneous onset of labor within 5 days in term pregnancies. They assist women and healthcare providers in determining the optimal time for hospital admission.
Article
Health Care Sciences & Services
Bedayah Amro, Iman Alhalabi, Anila George, Hanan Haroun, Amar Hassan Khamis, Nadia Al Sawalhi
Summary: This study aimed to evaluate the impact of the fetal fibronectin (FFN) test on the admission rate of threatened preterm labor, aiming to reduce hospital resources at Latifa Hospital, UAE. The results showed a 7% reduction in threatened preterm labor admissions after the introduction of the FFN test.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emmeli Mikkelsen, Berthold Huppertz, Ripudaman Singh, Katarina Ravn, Lotte Hatt, Mogens Kruhoffer, Rheanna Urrabaz-Garza, Niels Uldbjerg, Ramkumar Menon, Torben Steiniche
Summary: Unique markers in fetal membrane cells may be key in the search for biomarkers for preterm prelabor rupture of the fetal membranes (pPROM) in maternal blood. Through transcriptomic analysis and immunohistochemistry, markers exclusively expressed in fetal membranes were identified and their localization confirmed. These findings contribute to the understanding of the biological significance of these markers in the maternal circulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sudeshna Bhunia, Shaughn O'Brien, Yuting Ling, Zhihong Huang, Pensee Wu, Ying Yang
Summary: This study compared the mechanical properties and behaviors of term and preterm human fetal membranes and investigated the expression levels of various biomarkers within the membranes. The findings suggest that preterm membranes have greater heterogeneity in mechanical properties and higher expression of MMP-9, MMP-13, and IL-1 beta when subjected to simulated fetal movement forces. These results provide insights into the mechanisms of preterm rupture of membranes.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Ladina Vonzun, Ladina Rueegg, Julia Zepf, Ueli Moehrlen, Martin Meuli, Nicole Ochsenbein-Koelble
Summary: This study assessed the value of preoperative cervical length, cervical length dynamics, and fetal fibronectin tests in predicting obstetric complications and length of stay after fetal spina bifida repair. The results showed that perioperative cervical length dynamics affect the length of stay after surgery, and patients with increment cervical length greater than or equal to 10mm until discharge have a higher preterm delivery rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Janet W. Rich-Edwards, Jennifer J. Stuart, Iris A. Becene, Louise F. Largier, Kathryn M. Rexrode, David E. Cantonwine, Maribel O. Carpenter, Thomas F. Mcelrath, Kathryn J. Gray
Summary: This study aimed to develop and test the validity of a questionnaire to classify preterm delivery subtypes based on parental recall of labor and delivery events.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Biology
Corinne Belville, Flora Ponelle-Chachuat, Marion Rouzaire, Christelle Gross, Bruno Pereira, Denis Gallot, Vincent Sapin, Loic Blanchon
Summary: The integrity of human fetal membranes is crucial for fetal development, and this study explores the regulation of toll-like receptor 4 (TLR4) in pathological premature rupture of membranes.
Article
Obstetrics & Gynecology
Minyan Liao, Limin Wang, Ning Shang, Xueyi Hu, Bingjia He, Xiangjiao Liu, Guanghua Xiang, Wei Zhong
Summary: This study investigated the associations between fetal facial profile measurements, crown-rump length, and congenital malformations during early pregnancy. The results showed significant correlations between these measurements and crown-rump length, as well as significant differences with certain congenital malformations.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Youwen Mei, Yuxin Ran, Zheng Liu, Yunqian Zhou, Jie He, Nanlin Yin, Hongbo Qi
Summary: The study revealed that IL-27 promotes Th1 cell infiltration in human fetal membranes in preterm labor through the JAK2/STAT1/STAT3 signaling pathway, upregulating the expression of CXCL9, CXCL10, and CXCL11.
REPRODUCTIVE SCIENCES
(2022)
Article
Mechanics
Heiko Topol, Niraj Kumar Jha, Hasan Demirkoparan, Marcus Stoffel
Summary: This article studies the inflation and bulging of fiber reinforced hyperelastic membranes to understand the mechanical behavior of arterial soft tissue and the formation of aneurysms.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2022)
Review
Obstetrics & Gynecology
Jingning Chen, Guoliang Gong, Wenhua Zheng, Jingyun Xu, Xiaowei Luo, Yuanxin Zhang
Summary: This study examined the predictive values of quantitative fetal fibronectin (fFN) for spontaneous preterm birth (sPTB) at different predefined thresholds through systematic review and meta-analysis. The results suggest that the threshold of 10 ng/ml fFN may be a new choice for predicting sPTB, and quantitative testing provides improved diagnostic accuracy compared to qualitative testing.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Medicine, General & Internal
Fanny Tevaearai, Maike Katja Sachs, Samia El-Hadad, Ladina Vonzun, Ueli Moehrlen, Luca Mazzone, Martin Meuli, Franziska Kraehenmann, Nicole Ochsenbein-Koelble
Summary: In women undergoing fSB repair surgery, there was no significant difference in the incidence of abnormal vaginal flora preoperatively and postoperatively, and abnormal vaginal microbiome was not associated with preterm prelabour rupture of membranes (PPROM) and preterm birth (PTB).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biology
Belen Gimeno-Molina, Ingrid Muller, Pascale Kropf, Lynne Sykes
Summary: Neutrophils are surveillance cells that play a key role in both sterile inflammation and infection. They are important in both term and preterm deliveries and contribute to tissue remodelling.
Article
Mechanics
Heiko Topol, Hadi Asghari, Marcus Stoffel, Bernd Markert, Jose Merodio
Summary: This article investigates the process of bubbling and bifurcation in a cylindrical membrane consisting of isotropic ground substance and fibers. It finds that material properties, fiber pre-stretch, fiber dispersion, and loading have significant effects on the initiation and post-bifurcation behavior.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2023)
Article
Obstetrics & Gynecology
Anastasia Martin, Diane Nzelu, Annette Briley, Graham Tydeman, Andrew Shennan
Summary: The use of the Tydeman Tube (TT) by trained operators provides greater fetal head elevation compared to digital elevation and the Fetal Pillow (FP) on a simulator. The FP achieves similar elevation to the digital technique, especially when the user is trained in the procedure.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Joan Camunas-Soler, Elaine P. S. Gee, Mitsu Reddy, Jia Dai Mi, Mainou Thao, Tiffany Brundage, Farooq Siddiqui, Natasha L. Hezelgrave, Andrew H. Shennan, Eugeni Namsaraev, Carrie Haverty, Maneesh Jain, Michal A. Elovitz, Morten Rasmussen, Rachel M. Tribe
Summary: The study found that cell-free RNA profiles in maternal blood during early pregnancy can effectively predict the risk of spontaneous preterm birth, providing a window into the future possibility of preterm birth. The research also identified specific genes and pathways associated with the risk of spontaneous preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Obstetrics & Gynecology
Alice Beardmore-Gray, Paul T. Seed, Jessica Fleminger, Eva Zwertbroek, Thomas Bernardes, Ben W. Mol, Cheryl Battersby, Corine Koopmans, Kim Broekhuijsen, Kim Boers, Michelle Y. Owens, Jim Thornton, Marcus Green, Andrew H. Shennan, Henk Groen, Lucy C. Chappell
Summary: This individual participant data meta-analysis compared planned delivery to expectant management in women with preeclampsia. The results showed that planned delivery from 34 weeks gestation onward reduced the risk of maternal morbidity and the likelihood of the infant being born small for gestational age. However, it also increased the risk of short-term neonatal respiratory morbidity.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Natalie Suff, Vicky X. Xu, Giorgia Dalla Valle, Jenny Carter, Shaun Brennecke, Andrew Shennan
Summary: This study investigated the risk of recurrent spontaneous preterm birth (sPTB) in women with a prior term birth and a subsequent sPTB. The results showed that women with a previous term birth had a higher risk of recurrent sPTB compared to women with only a history of sPTB. The etiology of sPTB may differ in this subgroup of women and further research is needed to identify and treat them effectively.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Alice Beardmore-Gray, Melanie Greenland, Louise Linsell, Edmund Juszczak, Pollyanna Hardy, Anna Placzek, Rachael Hunter, Jenie Sparkes, Marcus Green, Andrew Shennan, Neil Marlow, Lucy C. Chappell
Summary: This study evaluated the optimal timing for delivery in late preterm pre-eclampsia to optimize long-term outcomes for infants and mothers. The results showed that neurodevelopmental assessments at 2 years of age for infants of women with late preterm pre-eclampsia were within normal range, regardless of whether planned delivery or expectant management was pursued.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
A. H. Shennan, L. Story
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Obstetrics & Gynecology
Natalie Suff, Vicky X. Xu, Agnieszka Glazewska-Hallin, Jenny Carter, Shaun Brennecke, Andrew Shennan
Summary: In women who have had a previous term caesarean section (EmCS) and have risk factors for preterm birth, the risk of a recurrent preterm birth is higher than in women without a previous EmCS. Furthermore, both first and second stage EmCS are associated with an increased risk of recurrent preterm birth.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Shawn Walker, Tisha Dasgupta, Andrew Shennan, Jane Sandall, Catey Bunce, Phoebe Roberts
Summary: This paper presents a study protocol for developing a Breech Core Outcome Set (Breech-COS) to evaluate the effectiveness of interventions for improving outcomes associated with term breech birth. The study involves a systematic literature review, a focus group discussion, an international Delphi survey, and a consensus meeting with stakeholders. The aim is to facilitate comparisons and improvements in maternal and neonatal outcomes through standardized outcome measurements in future studies.
Article
Obstetrics & Gynecology
George Daskalakis, Vasilios Pergialiotis, Magnus Domelloef, Harald Ehrhardt, Gian Carlo Di Renzo, Esin Koc, Ariadne Malamitsi-Puchner, Marian Kacerovsky, Neena Modi, Andrew Shennan, Diogo Ayres-de-Campos, Elko Gliozheni, Kristiina Rull, Thorsten Braun, Artur Beke, Katarzyna Kosinska-Kaczynska, Ana Luisa Areia, Simona Vladareanu, Tanja Premru Srsen, Thomas Schmitz, Bo Jacobsson
Summary: Corticosteroids should be given to pregnant women between 24 and 33 weeks of gestation, when preterm birth is expected within the next seven days, as they have been proven to reduce neonatal mortality and morbidity. In some cases, this period can be extended up to 34(+6) weeks. It is recommended to administer the corticosteroids within 7 days of delivery, even with a single dose, to improve neurodevelopmental outcome. Betamethasone or dexamethasone can be used as corticosteroids.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Cristina Fernandez Turienzo, Louise H. Hull, Kirstie Coxon, Mary Bollard, Pauline Cross, Paul T. Seed, Andrew H. Shennan, Jane Sandall
Summary: This study evaluated the implementation and effectiveness of the POPPIE care model, which combines midwifery continuity of care with a specialist obstetric clinic, for pregnant women at risk of preterm birth in London, UK. The results showed that the POPPIE model was feasible, acceptable, and implemented with high fidelity and sustainability. The importance of this study lies in providing a new care model for improving the care of pregnant women at risk of preterm birth.
Article
Medicine, General & Internal
Ioannis Gallos, Adam Devall, James Martin, Lee Middleton, Leanne Beeson, Hadiza Galadanci, Fadhlun Alwy Al-beity, Zahida Qureshi, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Lumaan Sheikh, George Gwako, Alfred Osoti, Ashraf Aswat, Kristie-Marie Mammoliti, Kulandaipalayam N. Sindhu, Marcelina Podesek, Isobelle Horne, Rebecca Timms, Idnan Yunas, Jenipher Okore, Mandisa Singata-Madliki, Edna Arends, Aminu A. Wakili, A. Mwampashi, Sidrah Nausheen, Shah Muhammad, Pallavi Latthe, Cherrie Evans, Shahinoor Akter, Gillian Forbes, David Lissauer, Shireen Meher, Andrew Weeks, Andrew Shennan, Anne Ammerdorffer, Eleanor Williams, Tracy Roberts, Mariana Widmer, Olufemi T. Oladapo, Fabiana Lorencatto, Meghan A. Bohren, Suellen Miller, Fernando Althabe, Metin Gulmezoglu, Jeffrey M. Smith, Karla Hemming, Arri Coomarasamy
Summary: This study aimed to evaluate a multicomponent clinical intervention for early detection and treatment of postpartum hemorrhage. The results showed that the use of a blood-collection drape and treatment bundle reduced the risk of severe postpartum hemorrhage and improved detection and adherence to treatment.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shawn Walker, Emma Spillane, Kate Stringer, Amy Meadowcroft, Tisha Dasgupta, Sian M. Davies, Jane Sandall, Andrew Shennan
Summary: OptiBreech Care is a feasible approach for providing care to breech presentation at term, with the goal of supporting physiologic breech birth attended by trained professionals. The study aimed to assess the feasibility of implementing OptiBreech team care prior to a planned pilot randomized controlled trial.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Obstetrics & Gynecology
Katy Kuhrt, Anastasia Martin, Lusako Paskali Mwaikasu, Andrew Shennan
Summary: Access to training and education in novel surgical and medical techniques is challenging in low-and-middle income settings, but video-based education tools can provide cost-effective and sustainable solutions, allowing clinicians in remote areas to develop new skills and improve patient care quality. A successful case in Tanzania showed how a clinician performed a transabdominal cerclage after studying a video developed by our team, resulting in successful pregnancy outcomes for two patients with poor obstetric histories. Video is a versatile medium that should be further integrated into surgical training curricula globally.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, General & Internal
Ioannis Gallos, Adam Devall, James Martin, Lee Middleton, Leanne Beeson, Hadiza Galadanci, Fadhlun Alwy Al-beity, Zahida Qureshi, G. Justus Hofmeyr, Neil Moran, Sue Fawcus, Lumaan Sheikh, George Gwako, Alfred Osoti, Ashraf Aswat, Kristie-Marie Mammoliti, Kulandaipalayam N. Sindhu, Marcelina Podesek, Isobelle Horne, Rebecca Timms, Idnan Yunas, Jenipher Okore, Mandisa Singata-Madliki, Edna Arends, Aminu A. Wakili, Ard Mwampashi, Sidrah Nausheen, Shah Muhammad, Pallavi Latthe, Cherrie Evans, Shahinoor Akter, Gillian Forbes, David Lissauer, Shireen Meher, Andrew Weeks, Andrew Shennan, Anne Ammerdorffer, Eleanor Williams, Tracy Roberts, Mariana Widmer, Olufemi T. Oladapo, Fabiana Lorencatto, Meghan A. Bohren, Suellen Miller, Fernando Althabe, Metin Gulmezoglu, Jeffrey M. Smith, Karla Hemming, Arri Coomarasamy
Summary: Early detection and bundled treatment of postpartum hemorrhage led to a lower risk of severe complications or death compared to usual care among patients undergoing vaginal delivery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Obstetrics & Gynecology
Jenny Carter, Naomi Carlisle, Anna David, Jane Sandall, Paul Seed, Andrew Shennan, Rachel Tribe, Helena Watson
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)