Global RNA profiles show target selectivity and physiological effects of peptide-delivered antisense antibiotics

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

(2021) Dina A. Moustafa et al.   mBio

Cross-species RNA-seq for deciphering host–microbe interactions

(2021) Alexander J. Westermann et al.   NATURE REVIEWS GENETICS

MAPS integrates regulation of actin-targeting effector SteC into the virulence control network of Salmonella small RNA PinT

(2021) Sara Correia Santos et al.   Cell Reports

Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling

(2020) Aubrie O’Rourke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial Peptide Nucleic Acids—Facts and Perspectives

(2020) Monika Wojciechowska et al.   MOLECULES

An RNA biology perspective on species‐specific programmable RNA antibiotics

(2020) Jörg Vogel   MOLECULAR MICROBIOLOGY

Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads

(2020) Gianluca Prezza et al.   RNA

Global discovery of bacterial RNA-binding proteins by RNase-sensitive gradient profiles reports a new FinO domain protein

(2020) Milan Gerovac et al.   RNA

Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CREEscherichia coli

(2020) Thomas R. Aunins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed Delay of a Virulence Circuit Promotes Salmonella Pathogenicity

(2019) Jeongjoon Choi et al.   mBio

The sRNA PinT contributes to PhoP-mediated regulation of the SPI1 T3SS in Salmonella enterica serovar Typhimurium

(2019) Kyungsub Kim et al.   JOURNAL OF BACTERIOLOGY

Envelope stress responses: balancing damage repair and toxicity

(2019) Angela M. Mitchell et al.   NATURE REVIEWS MICROBIOLOGY

Influence of different Cell-Penetrating Peptides on the antimicrobial efficiency of antisense Peptide Nucleic Acids in Streptococcus pyogenes

(2019) Gina Barkowsky et al.   Molecular Therapy-Nucleic Acids

Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae

(2018) Bruce L Geller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chlortetracycline and florfenicol induce expression of genes associated with pathogenicity in multidrug-resistant Salmonella enterica serovar Typhimurium

(2018) Devin B. Holman et al.   Gut Pathogens

Extensive reshaping of bacterial operons by programmed mRNA decay

(2018) Daniel Dar et al.   PLoS Genetics

Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection

(2018) Seth M. Daly et al.   ACS Infectious Diseases

In Vivo Cleavage Map Illuminates the Central Role of RNase E in Coding and Non-coding RNA Pathways

(2017) Yanjie Chao et al.   MOLECULAR CELL

Antibacterial Peptide Nucleic Acid–Antimicrobial Peptide (PNA–AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

(2016) Anna Mette Hansen et al.   BIOCONJUGATE CHEMISTRY

Antisense antimicrobial therapeutics

(2016) Erin K Sully et al.   CURRENT OPINION IN MICROBIOLOGY

A feed-forward loop between SroC and MgrR small RNAs modulates the expression of eptB and the susceptibility to polymyxin B in Salmonella Typhimurium

(2016) Lillian G. Acuña et al.   MICROBIOLOGY-SGM

Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions

(2016) Alexander J. Westermann et al.   NATURE

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

(2016) Dilay Hazal Ayhan et al.   PLOS BIOLOGY

The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium

(2016) Aoife M. Colgan et al.   PLoS Genetics

Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens

(2016) Mostafa F. N. Abushahba et al.   Scientific Reports

S. Typhimurium strategies to resist killing by cationic antimicrobial peptides

(2015) Susana Matamouros et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA

(2015) M. Miyakoshi et al.   EMBO JOURNAL

Diverse mechanisms of post-transcriptional repression by the small RNA regulator of glucose-phosphate stress

(2015) Maksym Bobrovskyy et al.   MOLECULAR MICROBIOLOGY

Simultaneous generation of many RNA-seq libraries in a single reaction

(2015) Alexander A Shishkin et al.   NATURE METHODS

How data analysis affects power, reproducibility and biological insight of RNA-seq studies in complex datasets

(2015) Lucia Peixoto et al.   NUCLEIC ACIDS RESEARCH

Messenger RNA Degradation in Bacterial Cells

(2014) Monica P. Hui et al.   Annual Review of Genetics

Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity

(2014) Zachary D Dalebroux et al.   CURRENT OPINION IN MICROBIOLOGY

Species-Selective Killing of Bacteria by Antimicrobial Peptide-PNAs

(2014) Madhav Mondhe et al.   PLoS One

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

(2014) Abiola O. Olaitan et al.   Frontiers in Microbiology

The Biology of the PmrA/PmrB Two-Component System: The Major Regulator of Lipopolysaccharide Modifications

(2013) H. Deborah Chen et al.   Annual Review of Microbiology

An Infection-Relevant Transcriptomic Compendium for Salmonella enterica Serovar Typhimurium

(2013) Carsten Kröger et al.   Cell Host & Microbe

Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo

(2013) B. L. Geller et al.   JOURNAL OF INFECTIOUS DISEASES

Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification

(2013) Kyung Moon et al.   MOLECULAR MICROBIOLOGY

Inhibition of Growth and Gene Expression by PNA-peptide Conjugates in Streptococcus pyogenes

(2013) Nadja Patenge et al.   Molecular Therapy-Nucleic Acids

Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

(2012) Anubrata Ghosal et al.   ACS Chemical Biology

The Seed Region of a Small RNA Drives the Controlled Destruction of the Target mRNA by the Endoribonuclease RNase E

(2012) Katarzyna J. Bandyra et al.   MOLECULAR CELL

The promoter architectural landscape of the Salmonella PhoP regulon

(2012) Igor Zwir et al.   MOLECULAR MICROBIOLOGY

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

RNA snap ™: a rapid, quantitative and inexpensive, method for isolating total RNA from bacteria

(2012) Mark B. Stead et al.   NUCLEIC ACIDS RESEARCH

The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium

(2012) C. Kroger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cationic antimicrobial peptides serve as activation signals for the Salmonella Typhimurium PhoPQ and PmrAB regulons in vitro and in vivo

(2012) Susan M. Richards et al.   Frontiers in Cellular and Infection Microbiology

Antisense inhibition of gene expression and growth in gram-negative bacteria by cell-penetrating peptide conjugates of peptide nucleic acids targeted to rpoD gene

(2011) Hui Bai et al.   BIOMATERIALS

Design, Synthesis and Characterization of a New Anionic Cell-Penetrating Peptide: SAP(E)

(2011) Irene Martín et al.   CHEMBIOCHEM

Pervasive post-transcriptional control of genes involved in amino acid metabolism by the Hfq-dependent GcvB small RNA

(2011) Cynthia M. Sharma et al.   MOLECULAR MICROBIOLOGY

ROAST: rotation gene set tests for complex microarray experiments

(2010) Di Wu et al.   BIOINFORMATICS

RNase P-dependent Cleavage of Polycistronic mRNAs within Their Downstream Coding Regions in Escherichia coli

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Modulation of Salmonella gene expression by subinhibitory concentrations of quinolones

(2010) Grace Yim et al.   JOURNAL OF ANTIBIOTICS

Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex

(2010) David E. Greenberg et al.   JOURNAL OF INFECTIOUS DISEASES

An antisense RNA that governs the expression kinetics of a multifunctional virulence gene

(2010) Eun-Jin Lee et al.   MOLECULAR MICROBIOLOGY

Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA

(2010) K. Papenfort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation

(2009) Verena Pfeiffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Concurrent Growth Rate and Transcript Analyses Reveal Essential Gene Stringency in Escherichia coli

(2009) Shan Goh et al.   PLoS One

Inactivation of expression of several genes in a variety of bacterial species by EGS technology

(2009) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency against Escherichia coli In Vitro and In Vivo

(2008) B. L. Mellbye et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Salmonellae PhoQ sensor: mechanisms of detection of phagosome signals

(2008) Lynne R. Prost et al.   CELLULAR MICROBIOLOGY

Small RNA Binding to 5′ mRNA Coding Region Inhibits Translational Initiation

(2008) Marie Bouvier et al.   MOLECULAR CELL

The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more

(2008) John S. Gunn   TRENDS IN MICROBIOLOGY