Targeting Central Nervous System Regeneration with Cell Type Specificity

Injured adult neurons regress to an embryonic transcriptional growth state

(2020) Gunnar H. D. Poplawski et al.   NATURE

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes

(2019) Nicholas M. Tran et al.   NEURON

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Dissecting spinal cord regeneration

(2018) Michael V. Sofroniew   NATURE

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

(2018) Leonie Asboth et al.   NATURE NEUROSCIENCE

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Intrinsic mechanisms of neuronal axon regeneration

(2018) Marcus Mahar et al.   NATURE REVIEWS NEUROSCIENCE

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury

(2018) Claudia A. Angeli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeted neurotechnology restores walking in humans with spinal cord injury

(2018) Fabien B. Wagner et al.   NATURE

Integrated systems analysis reveals conserved gene networks underlying response to spinal cord injury

(2018) Jordan W Squair et al.   eLife

Cell biology of spinal cord injury and repair

(2017) Timothy M. O’Shea et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell transplantation therapy for spinal cord injury

(2017) Peggy Assinck et al.   NATURE NEUROSCIENCE

Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others

(2017) Michael W. Norsworthy et al.   NEURON

A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions

(2017) Yuanyuan Liu et al.   NEURON

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury

(2017) Yilong Ren et al.   Scientific Reports

Restoration of Visual Function by Enhancing Conduction in Regenerated Axons

(2016) Fengfeng Bei et al.   CELL

Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics

(2016) Karthik Shekhar et al.   CELL

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration

(2016) Ken Kadoya et al.   NATURE MEDICINE

Intrinsic Control of Axon Regeneration

(2016) Zhigang He et al.   NEURON

Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury

(2015) Y. Zhu et al.   NEUROBIOLOGY OF DISEASE

Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms

(2015) Homaira Nawabi et al.   NEURON

Injury-Induced Decline of Intrinsic Regenerative Ability Revealed by Quantitative Proteomics

(2015) Stephane Belin et al.   NEURON

Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

(2015) Xin Duan et al.   NEURON

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans

(2014) Claudia A. Angeli et al.   BRAIN

The Fibrotic Scar in Neurological Disorders

(2014) Francisco Fernández-Klett et al.   BRAIN PATHOLOGY

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

(2014) K. Bartus et al.   JOURNAL OF NEUROSCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Extracellular matrix alterations, accelerated leukocyte infiltration and enhanced axonal sprouting after spinal cord hemisection in tenascin-C-deficient mice

(2013) Jenny Schreiber et al.   ACTA HISTOCHEMICA

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

(2013) K. Zukor et al.   JOURNAL OF NEUROSCIENCE

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

A Novel Growth-Promoting Pathway Formed by GDNF-Overexpressing Schwann Cells Promotes Propriospinal Axonal Regeneration, Synapse Formation, and Partial Recovery of Function after Spinal Cord Injury

(2013) L.-X. Deng et al.   JOURNAL OF NEUROSCIENCE

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

(2013) C. Soderblom et al.   JOURNAL OF NEUROSCIENCE

Heterogeneity of reactive astrocytes

(2013) Mark A. Anderson et al.   NEUROSCIENCE LETTERS

Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice

(2013) H. Sabelstrom et al.   SCIENCE

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

(2012) Paul Lu et al.   CELL

Role of the lesion scar in the response to damage and repair of the central nervous system

(2012) Hitoshi Kawano et al.   CELL AND TISSUE RESEARCH

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

(2012) R. van den Brand et al.   SCIENCE

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study

(2011) Susan Harkema et al.   LANCET

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

Cell survival or cell death: differential vulnerability of long descending and thoracic propriospinal neurons to low thoracic axotomy in the adult rat

(2011) A.C. Conta Steencken et al.   NEUROSCIENCE

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

A Pericyte Origin of Spinal Cord Scar Tissue

(2011) C. Goritz et al.   SCIENCE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Spinal Interneuron Axons Spontaneously Regenerate after Spinal Cord Injury in the Adult Feline

(2009) K. K. Fenrich et al.   JOURNAL OF NEUROSCIENCE

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

Transformation of nonfunctional spinal circuits into functional states after the loss of brain input

(2009) Grégoire Courtine et al.   NATURE NEUROSCIENCE

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

KLF Family Members Regulate Intrinsic Axon Regeneration Ability

(2009) D. L. Moore et al.   SCIENCE

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury

(2008) Edmund R. Hollis et al.   EXPERIMENTAL NEUROLOGY

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

Reflections

(2008) Martin E. Schwab et al.   NEURON

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

(2008) Konstantinos Meletis et al.   PLOS BIOLOGY