Mas-related G protein-coupled receptors (Mrgprs) - Key regulators of neuroimmune interactions

Interplay between physiological systems in the body plays a prominent role in health and disease. At the cellular level, such interplay is orchestrated through the binding of specific ligands to their receptors expressed on cell surface. G protein-coupled receptors (GPCR) are seven-transmembrane domain receptors that initiate various cellular responses and regulate homeostasis. In this review, we focus on particular GPCRs named Mas-related G protein-coupled receptors (Mrgprs) mainly expressed by sensory neurons and specialized immune cells. We describe the different subfamilies of Mrgprs and their specific ligands, as well as recent advances in the field that illustrate the role played by these receptors in neuro-immune biological processes, including itch, pain and inflammation in diverse organs.

Automated summary

This review focuses on Mrgprs, a specific subfamily of GPCRs expressed mainly by sensory neurons and specialized immune cells, and discusses their role in neuro-immune biological processes such as itch, pain, and inflammation in various organs. This research helps to deepen understanding of the mechanisms underlying diseases such as pain, itch, and inflammation.