Essential Tremor – A Cerebellar Driven Disorder?

Essential tremor pathology: neurodegeneration and reorganization of neuronal connections

(2020) Elan D. Louis et al.   Nature Reviews Neurology

LINGO1 is a regulatory subunit of large conductance, Ca2+-activated potassium channels

(2020) Srikanth Dudem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purkinje cell misfiring generates high-amplitude action tremors that are corrected by cerebellar deep brain stimulation

(2020) Amanda M Brown et al.   eLife

A Slow Short-Term Depression at Purkinje to Deep Cerebellar Nuclear Neuron Synapses Supports Gain-Control and Linear Encoding over Second-Long Time Windows

(2020) Christine M. Pedroarena   JOURNAL OF NEUROSCIENCE

Neural Evidence of the Cerebellum as a State Predictor

(2019) Hirokazu Tanaka et al.   CEREBELLUM

Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor

(2019) Daniel Kroneberg et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Eye movement abnormalities in essential tremor versus tremor dominant Parkinson’s disease

(2019) F. Visser et al.   CLINICAL NEUROPHYSIOLOGY

White matter rather than gray matter damage characterizes essential tremor

(2019) Sara Pietracupa et al.   EUROPEAN RADIOLOGY

The use of transcranial magnetic stimulation as a treatment for movement disorders: A critical review

(2019) Anna Latorre et al.   MOVEMENT DISORDERS

Deletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments

(2019) Nobutake Hosoi et al.   JOURNAL OF NEUROSCIENCE

Role of cerebellar GABAergic dysfunctions in the origins of essential tremor

(2019) Xu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular organization of cerebellar climbing fiber inputs during goal-directed behavior

(2019) Shinichiro Tsutsumi et al.   eLife

A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: Results at the 2-year follow-up

(2018) Jin Woo Chang et al.   ANNALS OF NEUROLOGY

Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1

(2018) Chandrakanth Reddy Edamakanti et al.   JOURNAL OF CLINICAL INVESTIGATION

Magnetic resonance–guided focused ultrasound thalamotomy for tremor: a report of 30 Parkinson's disease and essential tremor cases

(2018) Menashe Zaaroor et al.   JOURNAL OF NEUROSURGERY

Neurological adverse event profile of magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor

(2018) Paul S. Fishman et al.   MOVEMENT DISORDERS

Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes

(2018) Danielle Lee et al.   PARKINSONISM & RELATED DISORDERS

Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD

(2018) Guy Cheron et al.   Scientific Reports

Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

(2018) Rashmi Sarnaik et al.   eLife

Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions

(2018) William Heffley et al.   NATURE NEUROSCIENCE

Revisiting the Clinical Phenomenology of “Cerebellar Tremor”: Beyond the Intention Tremor

(2018) Abhishek Lenka et al.   CEREBELLUM

Clinical improvement associated with targeted interruption of the cerebellothalamic tract following MR-guided focused ultrasound for essential tremor

(2017) J. Levi Chazen et al.   JOURNAL OF NEUROSURGERY

Re-emergent tremor in Parkinson's disease

(2017) Daniele Belvisi et al.   PARKINSONISM & RELATED DISORDERS

Climbing fiber-Purkinje cell synaptic pathology in tremor and cerebellar degenerative diseases

(2016) Sheng-Han Kuo et al.   ACTA NEUROPATHOLOGICA

Progressive gait ataxia following deep brain stimulation for essential tremor: adverse effect or lack of efficacy?

(2016) Martin M. Reich et al.   BRAIN

Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat

(2016) Hassan Abbassian et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cerebellar dysfunction in essential tremor

(2016) Ritsuko Hanajima et al.   MOVEMENT DISORDERS

Transcranial Direct Current Stimulation in the Treatment of Essential Tremor

(2016) Nesrin Helvaci Yilmaz et al.   NEUROLOGIST

Timing Rules for Synaptic Plasticity Matched to Behavioral Function

(2016) Aparna Suvrathan et al.   NEURON

Excitatory Amino acid transporter expression in the essential tremor dentate nucleus and cerebellar cortex: A postmortem study

(2016) Jie Wang et al.   PARKINSONISM & RELATED DISORDERS

Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex

(2016) Josef Turecek et al.   Cell Reports

Motor network disruption in essential tremor: a functional and effective connectivity study

(2015) Arthur W. G. Buijink et al.   BRAIN

Mapping Purkinje Cell Placement Along the Purkinje Cell Layer: an Analysis of Postmortem Tissue from Essential Tremor Patients vs. Controls

(2015) Elan D. Louis et al.   CEREBELLUM

Structure-Function Relationships between Aldolase C/Zebrin II Expression and Complex Spike Synchrony in the Cerebellum

(2015) S. Tsutsumi et al.   JOURNAL OF NEUROSCIENCE

Climbing fiber synaptic changes correlate with clinical features in essential tremor

(2015) R. J. Louis et al.   NEUROLOGY

Integrated plasticity at inhibitory and excitatory synapses in the cerebellar circuit

(2015) Lisa Mapelli et al.   Frontiers in Cellular Neuroscience

Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor

(2014) Elan D. Louis et al.   BRAIN

Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum

(2014) Chi-Ying Lin et al.   BRAIN

Torpedo Formation and Purkinje Cell Loss: Modeling their Relationship in Cerebellar Disease

(2014) Elan D. Louis et al.   CEREBELLUM

Cerebellar Endocannabinoids: Retrograde Signaling from Purkinje Cells

(2014) Païkan Marcaggi   CEREBELLUM

Increased LINGO1 in the cerebellum of essential tremor patients

(2014) Charlotte Delay et al.   MOVEMENT DISORDERS

Activity-Dependent Gating of Calcium Spikes by A-type K+ Channels Controls Climbing Fiber Signaling in Purkinje Cell Dendrites

(2014) Yo Otsu et al.   NEURON

Releasing Dentate Nucleus Cells from Purkinje Cell Inhibition Generates Output from the Cerebrocerebellum

(2014) Takahiro Ishikawa et al.   PLoS One

Decreased EAAT2 protein expression in the essential tremor cerebellar cortex

(2014) Michelle Lee et al.   Acta Neuropathologica Communications

Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau

(2013) Sheng-Han Kuo et al.   ACTA NEUROPATHOLOGICA

Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains

(2013) Rachel Babij et al.   BRAIN

Enhanced Synaptic Inhibition in the Cerebellar Cortex of the Ataxic PMCA2−/− Knockout Mouse

(2013) Ruth M. Empson et al.   CEREBELLUM

The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls

(2013) Elan D. Louis et al.   MOVEMENT DISORDERS

The  2 glutamate receptor gates long-term depression by coordinating interactions between two AMPA receptor phosphorylation sites

(2013) K. Kohda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of cerebellar microzonal organization in GluD2 (GluRδ2) knockout mouse

(2013) Miki Hashizume et al.   Frontiers in Neural Circuits

Cerebellar rTMS stimulation may induce prolonged clinical benefits in essential tremor, and subjacent changes in functional connectivity: An open label trial

(2012) T. Popa et al.   Brain Stimulation

Diversity of Neuronal Elements and Circuitry in the Cerebellar Nuclei

(2012) Marylka Yoe Uusisaari et al.   CEREBELLUM

Assessing Glutamatergic Function and Dysfunction in Peripheral Tissues

(2012) L. Tremolizzo et al.   CURRENT MEDICINAL CHEMISTRY

Glutamate Receptor  2 Associates with Metabotropic Glutamate Receptor 1 (mGluR1), Protein Kinase C , and Canonical Transient Receptor Potential 3 and Regulates mGluR1-Mediated Synaptic Transmission in Cerebellar Purkinje Neurons

(2012) A. S. Kato et al.   JOURNAL OF NEUROSCIENCE

Defective dentate nucleus GABA receptors in essential tremor

(2011) Sarah Paris-Robidas et al.   BRAIN

Torpedoes in the Cerebellar Vermis in Essential Tremor Cases vs. Controls

(2011) Elan D. Louis et al.   CEREBELLUM

Biomarkers demonstrate increased consumption, but not abuse, of ethanol in essential tremor

(2011) Olga Ulmanová et al.   JOURNAL OF NEUROLOGY

Projected numbers of people with movement disorders in the years 2030 and 2050

(2011) Jan-Philipp Bach et al.   MOVEMENT DISORDERS

Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei

(2011) Abigail L. Person et al.   NATURE

In Vivo Analysis of Inhibitory Synaptic Inputs and Rebounds in Deep Cerebellar Nuclear Neurons

(2011) Fredrik Bengtsson et al.   PLoS One

Parallel fiber counts and parallel fiber integrated density are similar in essential tremor cases and controls

(2010) Sheng-Han Kuo et al.   ACTA NEUROPATHOLOGICA

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

"Hairy Baskets” Associated With Degenerative Purkinje Cell Changes in Essential Tremor

(2010) Cordelia R. Erickson-Davis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Ablation of Glutamate Receptor GluR 2 in Adult Purkinje Cells Causes Multiple Innervation of Climbing Fibers by Inducing Aberrant Invasion to Parallel Fiber Innervation Territory

(2010) T. Miyazaki et al.   JOURNAL OF NEUROSCIENCE

Intrinsic Plasticity Complements Long-Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells

(2010) A. Belmeguenai et al.   JOURNAL OF NEUROSCIENCE

GABAergic Dysfunction in Essential Tremor: An 11C-Flumazenil PET Study

(2010) H. Boecker et al.   JOURNAL OF NUCLEAR MEDICINE

Endocannabinoid-mediated synaptically evoked suppression of GABAergic transmission in the cerebellar cortex

(2010) M.J. Urbanski et al.   NEUROSCIENCE

CaV3.1 is a tremor rhythm pacemaker in the inferior olive

(2010) Y.-G. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbln1 Is a Ligand for an Orphan Glutamate Receptor  2, a Bidirectional Synapse Organizer

(2010) K. Matsuda et al.   SCIENCE

Functions of glutamate transporters in cerebellar Purkinje cell synapses

(2009) Y. Takayasu et al.   Acta Physiologica

Balance and Motor Speech Impairment in Essential Tremor

(2009) Martin Kronenbuerger et al.   CEREBELLUM

Motor learning in essential tremor

(2009) Holly A. Shill et al.   MOVEMENT DISORDERS

Variant in the sequence of the LINGO1 gene confers risk of essential tremor

(2009) Hreinn Stefansson et al.   NATURE GENETICS

BK Channels Control Cerebellar Purkinje and Golgi Cell Rhythmicity In Vivo

(2009) Guy Cheron et al.   PLoS One

LINGO-1 and its role in CNS repair

(2008) Sha Mi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Projection of reconstructed single purkinje cell axons in relation to the cortical and nuclear aldolase C compartments of the rat cerebellum

(2008) Izumi Sugihara et al.   JOURNAL OF COMPARATIVE NEUROLOGY