Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours

(2020) Fei Xu et al.   Cell and Bioscience

The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction

(2020) B. A. Kermath et al.   MOLECULAR PSYCHIATRY

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

(2019) Richard Karlsson Linnér et al.   NATURE GENETICS

Dysregulated Prefrontal Cortical RhoA Signal Transduction in Bipolar Disorder with Psychosis: New Implications for Disease Pathophysiology

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Genome-wide association study identifies 30 loci associated with bipolar disorder

(2019) Eli A. Stahl et al.   NATURE GENETICS

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

(2018) Douglas M. Ruderfer et al.   CELL

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

(2018) Antonio F. Pardiñas et al.   NATURE GENETICS

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

(2018) James J. Lee et al.   NATURE GENETICS

Gamma Oscillation Dysfunction in mPFC Leads to Social Deficits in Neuroligin 3 R451C Knockin Mice

(2018) Wei Cao et al.   NEURON

Regulation and Roles of Autophagy at Synapses

(2018) Vassiliki Nikoletopoulou et al.   TRENDS IN CELL BIOLOGY

Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

(2018) Francisco T. Gallo et al.   Frontiers in Behavioral Neuroscience

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The characteristics of psychotic features in bipolar disorder

(2018) Annet H. van Bergen et al.   PSYCHOLOGICAL MEDICINE

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity

(2018) Sonali Uttam et al.   Frontiers in Genetics

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(2017) Maria Zachari et al.   Essays in Biochemistry

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(2017) Brisa Solé et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neurocognition in patients with psychotic and non-psychotic bipolar I disorder. A comparative study with individuals with schizophrenia

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Cognitive Impairment in Euthymic Pediatric Bipolar Disorder: A Systematic Review and Meta-Analysis

(2017) Liana R. Elias et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling

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Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

(2017) Zhiqiang Li et al.   NATURE GENETICS

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(2017) Gareth R I Barker et al.   NATURE NEUROSCIENCE

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis

(2017) Brian T. D. Tobe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Neuronal Activity in the Medial Prefrontal Cortex during Social Approach Behavior

(2016) E. Lee et al.   JOURNAL OF NEUROSCIENCE

Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling

(2016) Michael E. Cahill et al.   NEURON

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

(2016) Rosemary C. Bagot et al.   NEURON

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

(2016) Keiichiro Minatohara et al.   Frontiers in Molecular Neuroscience

Genome-wide association study of schizophrenia in Ashkenazi Jews

(2015) Fernando S. Goes et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

An evaluation of variation in published estimates of schizophrenia prevalence from 1990─2013: a systematic literature review

(2015) Jason C. Simeone et al.   BMC Psychiatry

The medial prefrontal cortex-lateral entorhinal cortex circuit is essential for episodic-like memory and associative object-recognition

(2015) Owen Y. Chao et al.   HIPPOCAMPUS

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(2015) Christian C. Dibble et al.   TRENDS IN CELL BIOLOGY

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(2015) Eirini Tsitsipa et al.   Annals of General Psychiatry

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Biological insights from 108 schizophrenia-associated genetic loci

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Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Neuronal representation of working memory in the medial prefrontal cortex of rats

(2014) Sheng-Tao Yang et al.   Molecular Brain

Prefrontal Cortical Dendritic Spine Pathology in Schizophrenia and Bipolar Disorder

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Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis

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(2013) Gregory B. Bissonette et al.   BEHAVIOURAL BRAIN RESEARCH

Abnormalities of brain response during encoding into verbal working memory among euthymic patients with bipolar disorder

(2013) Benjamin S McKenna et al.   BIPOLAR DISORDERS

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Lateral entorhinal cortex is critical for novel object-context recognition

(2013) David I.G. Wilson et al.   HIPPOCAMPUS

Role of Medial Prefrontal Cortex Serotonin 2A Receptors in the Control of Retrieval of Recognition Memory in Rats

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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Assessing Working Memory via N-Back Task in Euthymic Bipolar I Disorder Patients: A Review of Functional Magnetic Resonance Imaging Studies

(2013) Laura Cremaschi et al.   NEUROPSYCHOBIOLOGY

Genetic overlap between schizophrenia and bipolar disorder: A study with AKT1 gene variants and clinical phenotypes

(2012) Félicien Karege et al.   SCHIZOPHRENIA RESEARCH

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(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

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(2011) Jun Noguchi et al.   JOURNAL OF PHYSIOLOGY-LONDON

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

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(2010) Lorenzo Mazzarini et al.   JOURNAL OF AFFECTIVE DISORDERS

Genetic association of the AKT1 gene with schizophrenia in a British population

(2010) Aditi Mathur et al.   PSYCHIATRIC GENETICS

fMRI abnormalities in dorsolateral prefrontal cortex during a working memory task in manic, euthymic and depressed bipolar subjects

(2010) Jennifer Townsend et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

mTOR phosphorylated at S2448 binds to raptor and rictor

(2009) M. Rosner et al.   AMINO ACIDS

Antidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats

(2009) Clement Hamani et al.   BIOLOGICAL PSYCHIATRY

Clinical and neurocognitive predictors of functional outcome in bipolar euthymic patients: A long-term, follow-up study

(2009) C.M. Bonnín et al.   JOURNAL OF AFFECTIVE DISORDERS

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth

(2009) H. A. Acosta-Jaquez et al.   MOLECULAR AND CELLULAR BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry

(2009) Yonghao Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative study of neurocognitive function in euthymic bipolar patients and stabilized schizophrenic patients

(2009) Eva María Sánchez-Morla et al.   PSYCHIATRY RESEARCH

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

Association of Dorsolateral Prefrontal Cortex Dysfunction With Disrupted Coordinated Brain Activity in Schizophrenia: Relationship With Impaired Cognition, Behavioral Disorganization, and Global Function

(2008) Jong H. Yoon et al.   AMERICAN JOURNAL OF PSYCHIATRY

Schizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality

(2008) J. McGrath et al.   EPIDEMIOLOGIC REVIEWS

Medial Prefrontal Cortex Supports Recollection, But Not Familiarity, in the Rat

(2008) A. Farovik et al.   JOURNAL OF NEUROSCIENCE

Prefrontal cortex and hippocampus subserve different components of working memory in rats

(2008) T. Yoon et al.   LEARNING & MEMORY