Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 56, Issue 7, Pages 2415-2422Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-016-1352-4
Keywords
Fish oil; n-3 polyunsaturated fatty acids; Type 2 diabetes; Abdominal obesity; Glycemic control; Lipid levels
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Funding
- National Natural Science Foundation of China [81573144]
- nutrition research foundation from the Chinese Nutrition Society [201326]
- Fundamental Research Funds for the Central Universities
- Graduate Research and Innovation Projects of Colleges in Jiangsu Province [KYLX15_0175]
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Purpose This study aimed to determine the effects of fish oil-derived n-3 PUFA on glycemic control and lipid profiles in type 2 diabetic patients with abdominal obesity. Methods In a randomized, double-blind, placebo-controlled trial, 100 type 2 diabetic patients with abdominal obesity were randomized into two groups including 4 g/day of fish oil (2.4 g n-3 PUFA) or placebo (corn oil) for 6 months. Serum fatty acid, body composition, as well as markers of glucose regulation and lipid parameters were measured before and after intervention. Results Thirty-five men and 64 women aged 65.4 +/- 5.3 years completed the intervention. Although body composition was unchanged, serum EPA and DHA were higher in the fish oil group than those in the placebo group (P < 0.001 and P < 0.001, respectively). Serum triglyceride (TG) decreased (P = 0.007), whereas high-density lipoprotein cholesterol (HDL-C) increased (P = 0.006) in the fish oil group compared with the placebo group after 6 months. Serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), the ratio of LDL-C to HDL-C, and glycemic control (measured by serum glucose, glycated hemoglobin, insulin, and homeostasis model assessment-insulin resistance) were not significantly different between the two groups after 6 months. Conclusions This study showed that 6 months of fish oil supplement had no statistically significant effects on glycemic control, but improved TG and HDL-C in type 2 diabetic patients with abdominal obesity.
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