Presenilin 1 mutation likely contributes to U1 small nuclear RNA dysregulation and Alzheimer's disease–like symptoms

A Preliminary Study: PS1 Increases U1 snRNA Expression Associated with AD

(2017) Zhi Cheng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Aggregates of Small Nuclear Ribonucleic Acids (snRNAs) in Alzheimer's Disease

(2014) Chadwick M. Hales et al.   BRAIN PATHOLOGY

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

(2014) Chadwick M Hales et al.   Molecular Neurodegeneration

Vitamins C and E reverse melamine-induced deficits in spatial cognition and hippocampal synaptic plasticity in rats

(2014) Lei An et al.   NEUROTOXICOLOGY

Insights into the U1 small nuclear ribonucleoprotein complex superfamily

(2014) J Guiro et al.   Wiley Interdisciplinary Reviews-RNA

RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism

(2013) James D. Mills et al.   NEUROSCIENCE LETTERS

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

U1 snRNP Determines mRNA Length and Regulates Isoform Expression

(2012) Michael G. Berg et al.   CELL

Weight loss and Alzheimer's disease: temporal and aetiologic connections

(2012) Giuseppe Sergi et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases

(2011) James Dominic Mills et al.   NEUROBIOLOGY OF AGING

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

(2010) Daisuke Kaida et al.   NATURE

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

Neuronal Apoptosis and Autophagy Cross Talk in Aging PS/APP Mice, a Model of Alzheimer's Disease

(2008) Dun-Sheng Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Medial septal β-amyloid 1-40 injections alter septo-hippocampal anatomy and function

(2008) Luis V. Colom et al.   NEUROBIOLOGY OF AGING

Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection

(2008) Steven W. Flavell et al.   NEURON