Article
Cardiac & Cardiovascular Systems
Andrew J. Einstein, Cole Hirschfeld, Michelle C. Williams, Joao V. Vitola, Nathan Better, Todd C. Villines, Rodrigo Cerci, Leslee J. Shaw, Andrew D. Choi, Sharmila Dorbala, Ganesan Karthikeyan, Bin Lu, Valentin Sinitsyn, Alexey A. Ansheles, Takashi Kudo, Chiara Bucciarelli-Ducci, Bjarne Linde Norgaard, Pal Maurovich-Horvat, Roxana Campisi, Elisa Milan, Lizette Louw, Adel H. Allam, Mona Bhatia, Lorenzo Sewanan, Eli Malkovskiy, Yosef Cohen, Michael Randazzo, Jagat Narula, Olga Morozova, Thomas N. B. Pascual, Yaroslav Pynda, Maurizio Dondi, Diana Paez
Summary: The study aimed to determine the impact of the COVID-19 pandemic on cardiac testing practices and volumes worldwide, showing recovery rates in high-income countries but stagnation in lower-income countries. Psychological stress among providers was found to affect patient care and recovery of cardiac testing.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Joseph M. Unger, Hong Xiao, Michael LeBlanc, Dawn L. Hershman, Charles D. Blanke
Summary: Clinical trial enrollments decreased during the full year of the COVID-19 pandemic, with reductions primarily seen in cancer control and prevention trials. However, there was not strong evidence of enrollment reductions in treatment trials, indicating that clinical research quickly adapted to enrolling and treating patients on protocols during the pandemic.
Article
Health Care Sciences & Services
Carolyn P. Chow, Christopher F. Chesley, Michaela Ward, Rebecca Neergaard, Taara V. Prasad, Erich M. Dress, Sara Reagan, Priyanka Kalyani, Nathan Smyk, Alexandra P. Turner, Roseline S. Agyekum, Caroline A. G. Ittner, Danielle K. Sandsmark, Nuala J. Meyer, Michael O. Harhay, Rachel Kohn, Catherine L. Auriemma
Summary: This study explores the recovery experiences of COVID-19 patients in the US, particularly focusing on medically underserved populations. Findings show that patients experienced persistent health deficits in physical, cognitive, and psychological aspects, leading to financial suffering and loss of identity. Clinicians' emphasis on physical health hindered holistic recovery, while facilitators included strong support systems and personal agency in health maintenance. Coping mechanisms involved spirituality and gratitude.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Letter
Medicine, General & Internal
Marion Renaud, Claire Thibault, Floriane Le Normand, Emily G. Mcdonald, Benoit Gallix, Christian Debry, Aina Venkatasamy
Summary: This cohort study examines the clinical course and prognosis of patients with COVID-19-related anosmia for 1 year after diagnosis.
Article
Biochemistry & Molecular Biology
Yan Zhan, Yufang Zhu, Shanshan Wang, Shijun Jia, Yunling Gao, Yingying Lu, Caili Zhou, Ran Liang, Dingwen Sun, Xiaobo Wang, Zhibing Hou, Qiaoqiao Hu, Peng Du, Hao Yu, Chang Liu, Miao Cui, Gangling Tong, Zhihua Zheng, Yunsheng Xu, Linyu Zhu, Jin Cheng, Feng Wu, Yulan Zheng, Peijun Liu, Peng Hong
Summary: Long-term immunity and functional recovery are observed in COVID-19 survivors, with high seroprevalence and stable total antibodies. However, decreased levels of specific antibodies and neutralization against variants pose a risk, especially for severe patients with lingering symptoms and organ involvement.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Genetics & Heredity
Maryam B. Khadzhieva, Alesya S. Gracheva, Olesya B. Belopolskaya, Dmitry S. Kolobkov, Darya A. Kashatnikova, Ivan V. Redkin, Artem N. Kuzovlev, Andrey V. Grechko, Lyubov E. Salnikova
Summary: Rare functional variants may contribute to COVID-19 severity by accumulating weak effects throughout the exome. The omnigenic model suggests that association signals spread across the genome through gene regulatory networks. In this study, whole-exome sequencing revealed an excess of rare, high-impact variants in severe COVID-19 patients, particularly in genes associated with immune and respiratory diseases.
FRONTIERS IN GENETICS
(2023)
Article
Respiratory System
Frederic Schlemmer, Simon Valentin, Laurent Boyer, Anne Guillaumot, Francois Chabot, Clairelyne Dupin, Pierre Le Guen, Gwenael Lorillon, Anne Bergeron, Damien Basille, Julia Delomez, Claire Andrejak, Valentine Bonnefoy, Helene Goussault, Jean-Baptiste Assie, Pascaline Choinier, Anne-Marie Ruppert, Jacques Cadranel, Maria Chiara Mennitti, Mehdi Roumila, Charlotte Colin, Sven Gunther, Olivier Sanchez, Thomas Gille, Lucile Sese, Yurdagul Uzunhan, Morgane Faure, Maxime Patout, Capucine Morelot-Panzini, Pierantonio Laveneziana, Maeva Zysman, Elodie Blanchard, Chantal Raherison-Semjen, Violaine Giraud, Etienne Giroux-Leprieur, Stefanie Habib, Nicolas Roche, Anh Tuan Dinh-Xuan, Islem Sifaoui, Pierre-Yves Brillet, Camille Jung, Emmanuelle Boutin, Richard Layese, Florence Canoui-Poitrine, Bernard Maitre
Summary: This pragmatic study aimed to describe the clinical follow-up and respiratory recovery trajectories of survivors of severe-to-critical COVID-19, as well as identify factors influencing their health-related quality of life. The results showed that although pulmonary function and radiological abnormalities improved up to 1 year post-acute COVID-19, a high percentage of severe-to-critical disease survivors had significant lung sequelae and residual symptoms, warranting prolonged follow-up.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jinhan Qiao, Peijun Zhao, Jianyao Lu, Lu Huang, Xiaoling Ma, Xiaoyue Zhou, Liming Xia
Summary: This study followed up patients with persistent cardiac symptoms after recovering from COVID-19 for one year and found that they had decreased cardiac function and increased extracellular volumes, mostly showing myocardial fibrosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Dapeng Li, Xuejiao Liao, Zhenghua Ma, Lina Zhang, Jingke Dong, Guoqin Zheng, Mei Zi, Wujian Peng, Lanlan Wei, Zhiyan Li, Yingjun Kong, Lifei Wang, Dongjing Liu, Fang Wang, Qing He, Guobao Li, Zheng Zhang, Lei Liu
Summary: This prospective cohort study evaluated the long-term clinical status of COVID-19 in recovered patients. The study found that one year after hospital discharge, patients continued to experience pulmonary and extrapulmonary dysfunction. Common symptoms reported included fatigue and sleep difficulties. Abnormal chest CT scans were found in the majority of patients, and kidney function declined persistently after discharge.
ANNALS OF INTENSIVE CARE
(2022)
Article
Computer Science, Information Systems
Jingcheng Du, Qing Wang, Jingqi Wang, Prerana Ramesh, Yang Xiang, Xiaoqian Jiang, Cui Tao
Summary: The study established a linked graph to facilitate the retrieval of COVID-19 clinical trials by extracting and normalizing clinical trial information, and using a graph database to support querying and visualization. The results showed that the COVID-19 Trial Graph had high precision and recall in case queries.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Siqin Wang, Xiao Huang, Bing She, Zhenlong Li
Summary: The COVID-19 pandemic has had catastrophic impacts on the restaurant industry. This study examines the effects of COVID-19 on the US restaurant industry using data from Yelp and SafeGraph. The findings provide quantitative evidence of lost restaurant visitations and revenue during the pandemic, changes in customer origins, and the diminishing distance-decay effect on visitations. These findings are useful for policymakers in monitoring economic relief measures and designing targeted policies for economic recovery.
Article
Respiratory System
Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstatter, David Haschka, Verena Petzer, Anna Boehm, Magdalena Aichner, Piotr Tymoszuk, Daniela Lener, Markus Theurl, Almut Lorsbach-Koehler, Amra Tancevski, Anna Schapfl, Marc Schaber, Richard Hilbe, Manfred Nairz, Bernhard Puchner, Doris Huettenberger, Christoph Tschurtschenthaler, Malte Asshoff, Andreas Peer, Frank Hartig, Romuald Bellmann, Michael Joannidis, Can Gollmann-Tepekoylu, Johannes Holfeld, Gudrun Feuchtner, Alexander Egger, Gregor Hoermann, Andrea Schroll, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Rudolf Kirchmair, Raimund Helbok, Helmut Prosch, Dietmar Rieder, Zlatko Trajanoski, Florian Kronenberg, Ewald Woell, Gunter Weiss, Gerlig Widmann, Judith Loeffler-Ragg, Ivan Tancevski
Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Medicine, General & Internal
Hidde Heesakkers, Johannes G. van der Hoeven, Stijn Corsten, Inge Janssen, Esther Ewalds, Koen S. Simons, Brigitte Westerhof, Thijs C. D. Rettig, Cretien Jacobs, Susanne van Santen, Arjen J. C. Slooter, Margaretha C. E. van der Woude, Mark van den Boogaard, Marieke Zegers
Summary: The study found that physical, mental, and cognitive symptoms were frequently reported among COVID-19 patients one year after ICU treatment.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Louis Dron, Alison Dillman, Michael J. Zoratti, Jonas Haggstrom, Edward J. Mills, Jay J. H. Park
Summary: During the COVID-19 pandemic, a large number of clinical trials have been conducted with many ending early due to feasibility issues, leading to inconclusive findings and potential false positives and negatives amidst a lack of common data standards for pooling results.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Immunology
Sara Baptista, Sanushka Naidoo, Sara Suliman, Emmanuel Nepolo, Bernard N. Kanoi, Jesse Gitaka, Oyedemi Mbaebie Blessing, Shymaa Enany
Summary: Africa continues to struggle in terms of COVID-19 vaccine distribution and faces challenges in vaccine development, deployment, and sustainability for other major infectious diseases. To address the ongoing vaccine shortage, Africa needs to diversify investments, improve vaccine acquisition capacity, and increase awareness about vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
