Computationally guided high-throughput design of self-assembling drug nanoparticles

Machine Learning Uncovers Food- and Excipient-Drug Interactions

(2020) Daniel Reker et al.   Cell Reports

“Inactive” ingredients in oral medications

(2019) Daniel Reker et al.   Science Translational Medicine

Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence

(2019) Ahil N. Ganesh et al.   ACS Chemical Biology

Computational advances in combating colloidal aggregation in drug discovery

(2019) Daniel Reker et al.   Nature Chemistry

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Part II: Onychomycosis: Treatment and Prevention of Recurrence

(2018) Shari R. Lipner et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Quantitative self-assembly prediction yields targeted nanomedicines

(2018) Yosi Shamay et al.   NATURE MATERIALS

Adversarial Controls for Scientific Machine Learning

(2018) Kangway V. Chuang et al.   ACS Chemical Biology

Bile Acids and Their Derivatives as Potential Modifiers of Drug Release and Pharmacokinetic Profiles

(2018) Nebojša Pavlović et al.   Frontiers in Pharmacology

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Stable Colloidal Drug Aggregates Catch and Release Active Enzymes

(2016) Christopher K. McLaughlin et al.   ACS Chemical Biology

Serum protein biomarkers relevant to hepatocellular carcinoma and their detection

(2016) Eric Waidely et al.   ANALYST

Multi-objective active machine learning rapidly improves structure–activity models and reveals new protein–protein interaction inhibitors

(2016) D. Reker et al.   Chemical Science

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Perspective: Special delivery for the gut

(2015) Giovanni Traverso et al.   NATURE

Meloxicam combined with sorafenib synergistically inhibits tumor growth of human hepatocellular carcinoma cells via ER stress-related apoptosis

(2015) JINGTAO ZHONG et al.   ONCOLOGY REPORTS

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice

(2014) Roman L. Bogorad et al.   Nature Communications

Antiretroviral Solid Drug Nanoparticles with Enhanced Oral Bioavailability: Production, Characterization, and In Vitro-In Vivo Correlation

(2013) Tom O. McDonald et al.   Advanced Healthcare Materials

Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture

(2012) Shawn C. Owen et al.   ACS Chemical Biology

Aggregating Behavior of Phenolic Compounds — A Source of False Bioassay Results?

(2012) Leena Pohjala et al.   MOLECULES

Downsizing tumour therapeutics

(2012) Christopher J. Cheng et al.   Nature Nanotechnology

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Multistage nanoparticle delivery system for deep penetration into tumor tissue

(2011) C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorafenib is active on lung metastases from synovial sarcoma

(2009) U. Basso et al.   ANNALS OF ONCOLOGY

Candidal onychomycosis: A Mini-Review

(2009) J. A. M. S. Jayatilake et al.   MYCOPATHOLOGIA

Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective

(2009) Mélanie Auffan et al.   Nature Nanotechnology

Review article: pharmacological therapy for hepatocellular carcinoma with sorafenib and other oral agents

(2008) M. CHAPARRO et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Glycyrrhizin surface-modified chitosan nanoparticles for hepatocyte-targeted delivery

(2008) Aihua Lin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS