NUCLEIC ACIDS Designing in vivo active DNAzymes

The therapeutic applications of DNAzymes are limited because of their low effectiveness in vivo. Now, a promising approach for constructing DNAzymes that show high gene-silencing efficiency in mammalian cells has been developed. This approach incorporates chemical modifications into an existing DNAzyme scaffold.

Automated summary

Therapeutic applications of DNAzymes are restricted due to their low effectiveness in vivo, but a promising approach has been developed to construct DNAzymes with high gene-silencing efficiency in mammalian cells by incorporating chemical modifications into an existing DNAzyme scaffold.