Article
Psychiatry
Wei Zheng, Miao-Ling Jiang, Hong-Bo He, Ri-Peng Li, Qi-Long Li, Chun-Ping Zhang, Su-Miao Zhou, Su Yan, Yu-Ping Ning, Xiong Huang
Summary: A study on Chinese patients with TRD showed that adjunctive NET could effectively improve depressive symptoms, enhance neurocognitive function, and does not lead to adverse neurocognitive effects. Randomized controlled studies are needed to confirm these findings.
PSYCHIATRIC QUARTERLY
(2021)
Review
Psychiatry
Dong-Bin Cai, Hua-Rong Zhou, Wan-Nian Liang, Li-Mei Gu, Mei He, Xiong Huang, Zhan-Ming Shi, Hua-Cheng Hou, Wei Zheng
Summary: The review found that adjunctive nonconvulsive electrotherapy (NET) may be a safe, well-tolerated, and effective therapy for depression based on limited evidence from 3 studies.
PSYCHIATRIC QUARTERLY
(2021)
Review
Psychiatry
Pao-Yuan Ching, Tien-Wei Hsu, Guan-Wei Chen, Chih-Chuan Pan, Che-Sheng Chu, Po-Han Chou
Summary: This study investigated the efficacy and tolerability of cranial electrotherapy stimulation (CES) for patients with anxiety symptoms. The results showed that CES significantly reduced anxiety symptoms with a moderate effect size. Subgroup analysis indicated that CES was effective for both primary and secondary anxiety, with better efficacy for primary anxiety. CES also reduced depressive symptoms in patients with anxiety disorders. The treatment was well-tolerated, with minimal side effects.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Feng-Chin Chung, Cheuk-Kwan Sun, Yi Chen, Yu-Shian Cheng, Weilun Chung, Ruu-Fen Tzang, Hsien-Jane Chiu, Ming-Yu Wang, Ying-Chih Cheng, Kuo-Chuan Hung
Summary: This meta-analysis found that electrical cranial stimulation (CES) has significant therapeutic effectiveness in reducing anxiety, depression, and insomnia in patients with anxiety symptoms. The use of the Alpha-Stim device for CES was particularly effective in alleviating anxiety.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Xianli An, Yaqing Wang
Summary: This study reviewed literature on neurotrophic signaling and cell proliferation after electroconvulsive shock (ECS) treatment, showing that repeated ECS can increase neurotrophin expression in more brain regions and cell proliferation in a dose-and time-dependent manner.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
J. Douglas Steele, Tom Farnan, David M. M. Semple, Siwei Bai
Summary: Recent observational studies have found that the cognitive side-effects and therapeutic efficacy of electroconvulsive therapy (ECT) are associated with electric field-induced changes in brain structures. A specific fronto-medial electrode placement has been found to reduce electric fields in the hippocampi while increasing electric fields in the dorsal sagittal cortex. This finding is clinically relevant as it may help minimize side-effects and improve treatment outcomes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Subha Subramanian, Ruthzaine Lopez, Charles F. Zorumski, Pilar Cristancho
Summary: This article provides a qualitative review of the effectiveness of electroconvulsive therapy (ECT) for treatment resistant depression (TRD), optimal ECT parameters for improved remission rates and fewer side effects, and proposed neurobiological mechanisms. It suggests that right unilateral (RUL) electrode placement is as effective as bilateral ECT for major depression and has fewer cognitive side effects. The methods for sustaining remission and the neurobiological mechanisms of ECT remain uncertain.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Randall T. Espinoza, Charles H. Kellner
Summary: Update on Electroconvulsive Therapy (ECT): ECT is effective for several disorders, notably severe or treatment-resistant depression, showing rapid response. However, stigma hampers its usage. The mechanism remains unknown, but a seizure is necessary for efficacy. ECT prominently affects memory, albeit transiently.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Psychiatry
George Kirov, Sameer Jauhar, Pascal Sienaert, Charles H. Kellner, Declan M. McLoughlin
Summary: Electroconvulsive therapy is considered one of the most effective treatments for severe, psychotic or treatment-resistant depression, but its effectiveness continues to be questioned.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Bin Wu, Yuanyuan Guo, Jie Deng, Qibin Chen, Su Min
Summary: The study conducted on rats modeling depressive-like behaviors found that depressed rats developed resistance to electric shocks following stress induction. Within five shocks, improvements were observed in sucrose preference and synaptic plasticity in depressed rats, while spatial learning and memory deficits worsened.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Ifat Israel-Elgali, Libi Hertzberg, Guy Shapira, Aviv Segev, Israel Krieger, Uri Nitzan, Yuval Bloch, Nir Pillar, Ori Mayer, Abraham Weizman, David Gurwitz, Noam Shomron
Summary: This study aimed to elucidate the transcriptional differences in peripheral blood mononuclear cells (PBMC) between individuals with treatment-resistant depression (TRD) and a control group. The findings suggest that the expression levels of FKBP5, ITGA2B, and miR-24-3p in PBMC could be further explored as potential biomarkers for ECT response.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Clinical Neurology
P. Parker Schwab, Amitha Dhingra, Hannah Chapman, Amanda C. Tan, William M. McDonald, Patricio Riva-Posse, A. Umair Janjua, Gregory Job, Rachel Hershenberg, Adriana P. Hermida
Summary: This study examined the safety and efficacy of UBRUL ECT for patients with late-life BD. Results showed significant symptomatic response and remission rates, with most patients experiencing improvement in clinical impression and cognitive status after treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Marta Cano, Erik Lee, Christopher Polanco, Tracy Barbour, Kristen K. Ellard, Blake Andreou, Sofia Uribe, Michael E. Henry, Stephen Seiner, Narcis Cardoner, Carles Soriano-Mas, Joan A. Camprodon
Summary: In this study, the authors compared the brain volumetric changes in patients with treatment-resistant depression (TRD) after receiving electroconvulsive therapy (ECT) or repetitive transcranial magnetic stimulation (rTMS). The results showed that patients who received ECT exhibited greater volumetric increase in certain brain regions compared to those who received rTMS. However, the changes in brain volume were not associated with clinical improvement.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Xiao Li, Jiamei Guo, Xiaolu Chen, Renqiang Yu, Wanjun Chen, Anhai Zheng, Yanjie Yu, Dongdong Zhou, Linqi Dai, Li Kuang
Summary: The efficacy of electroconvulsive therapy (ECT) in the treatment of adolescents with treatment-refractory depression is unsatisfactory, and it is unclear which factors are related to the treatment effect. Resting-state fMRI may be a good tool to predict the clinical efficacy of this treatment and identify the most suitable population for it.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Jurjen J. Luykx, Dore Loef, Bochao Lin, Linda van Diermen, Jasper O. Nuninga, Eric van Exel, Mardien L. Oudega, Didi Rhebergen, Sigfried N. T. M. Schouws, Philip van Eijndhoven, Esmee Verwijk, Didier Schrijvers, Tom K. Birkenhager, Karen M. Ryan, Baer Arts, Suzanne C. van Bronswijk, Gunter Kenis, Geert Schurgers, Bernhard T. Baune, Martijn Arns, Edwin E. van Dellen, Metten Somers, Iris E. C. Sommer, Marco P. Boks, Sinan Guloksuz, Declan M. McLoughlin, Annemiek Dols, Bart P. F. Rutten
Summary: This study revealed a linear association between PRS-SCZ and ECT outcome, which strengthens the relevance of PRS-SCZ to treatment response in psychiatry.
BIOLOGICAL PSYCHIATRY
(2022)