Journal
NANO LETTERS
Volume 21, Issue 7, Pages 2926-2931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c00009
Keywords
magnetic nanoparticles; free radicals; deep penetration depth; tumor hypoxia; photodynamic therapy
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Funding
- National Natural Science Foundation of China [81501461, 21635002]
- Natural Science Foundation of Fujian Province of China [2018J01896]
- Joint Funds for the Innovation of Science and Technology, Fujian Province [2017Y9041]
- Scientific Foundation of Fujian Provincial Health Commission [2018-ZQN-37, 2016-1-44]
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This study introduces a novel magnetothermodynamic strategy for deep-seated tumor therapy, utilizing porous hollow iron oxide nanoparticles (PHIONs) loaded with a radical initiator (AIPH) to generate heat under an alternating magnetic field, triggering the release and decomposition of free radicals to effectively kill cancer cells under hypoxic conditions.
Tumor hypoxia and the tissue penetration limitation of excitation light hamper the widespread clinical use of photodynamic therapy. The development of new therapeutic strategies that can generate oxygen-independent free radicals without penetration depth limitation is of great demand. Herein, a novel magnetothermodynamic strategy for deep-seated tumor therapy is reported. In this system, a radical initiator (AIPH) was loaded into porous hollow iron oxide nanoparticles (PHIONs). Under the induction of an alternating magnetic field (AMF), PHIONs can generate heat to trigger the release and decomposition of AIPH, resulting in the generation of oxygen-independent alkyl radicals. The resulting alkyl radicals can effectively kill cancer cells under hypoxic conditions. More importantly, this magnetothermally triggered free-radical generator exhibits significant therapeutic efficacy for orthotopic liver tumors in a rat model. This magnetothermodynamic therapy strategy with the advantages of oxygen independence and no limitation of penetration depth holds great promise in deep-seated solid tumor treatment.
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