Journal
MUCOSAL IMMUNOLOGY
Volume 14, Issue 4, Pages 803-814Publisher
ELSEVIER SCIENCE INC
DOI: 10.1038/s41385-021-00391-w
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Funding
- INSERM
- Laboratoire d'Excellence consortium Inflamex [ANR-11-IDEX-0005-02]
- Agence Nationale de la Recherche [ANR-17-CE14-0002-01 Diab1MAIT, ANR-19-CE14-0041-01 HEPADIMAIT]
- Fondation pour la Recherche Medicale [EQU201903007779]
- EFSD/JDRF/Lilly
- EFSD/Lilly grant
- Aide aux Jeunes Diabetiques fellowship
- Ministry of Research PhD grant
- Federation Francaise des Diabetiques (FFD)
- Abbott
- AstraZeneca
- Eli Lilly
- Merck Sharp Dohme (MSD)
- Novo Nordisk
- FFRD
- CNRS
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Mucosal Associated Invariant T (MAIT) cells play an important role in protecting and maintaining mucosal barriers, but may also be involved in immune and inflammatory pathologies affecting these organs.
Mucosal Associated Invariant T (MAIT) cells are evolutionary conserved innate-like T cells able to recognize bacterial and fungal ligands derived from vitamin B biosynthesis. These cells are particularly present in liver and blood but also populate mucosal sites including skin, oral, intestinal, respiratory, and urogenital tracts that are in contact with the environment and microbiota of their host. Growing evidence suggests important involvement of MAIT cells in safeguarding the mucosa against external microbial threats. Simultaneously, mucosal MAIT cells have been implicated in immune and inflammatory pathologies affecting these organs. Here, we review the specificities of mucosal MAIT cells, their functions in the protection and maintenance of mucosal barriers, and their interactions with other mucosal cells.
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