Article
Multidisciplinary Sciences
Eriya Shimada, Hiroyasu Kanetaka, Hiroki Hihara, Akitake Kanno, Ryuta Kawashima, Nobukazu Nakasato, Kaoru Igarashi
Summary: The periodontal ligaments play a crucial role in our daily life, especially in perceiving food size or hardness, determining jaw position, and adjusting masticatory strength. This study investigates the sensory characteristics of the periodontal ligaments, focusing on the maxillary and mandibular first molars. The results show that neural signals from the mandibular periodontal ligaments pass faster and more intensely to the central nervous system compared to those from the maxillary periodontal ligaments, suggesting their preferential involvement in the adjustment of occlusal force and position.
Article
Multidisciplinary Sciences
Zachary P. Rosenthal, Ryan Raut, Ryan M. Bowen, Abraham Z. Snyder, Joseph P. Culver, Marcus E. Raichle, Jin-Moo Lee
Summary: Slow waves, crucial for neural plasticity and memory, were found to be globally propagating low-frequency oscillations during sleep and anesthesia. Experimental results showed that somatosensory stimulation can evoke bilateral waves and under anesthesia, rhythmic stimuli can elicit globally resonant, front-to-back propagating slow waves.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Eriya Shimada, Hiroki Hihara, Chihiro Kitayama, Akitake Kanno, Ryuta Kawashima, Akimitsu Sato, Yoshimichi Imai, Nobukazu Nakasato, Kaoru Igarashi, Hiroyasu Kanetaka
Summary: This study compared the palatal sensation of patients with cleft palate after palatoplasty with healthy subjects, finding higher palatal sensory thresholds in patients with cleft palate possibly due to central nervous system compensation mechanisms. Somatosensory evoked magnetic fields provide effective objective evaluation of palatal sensation in these patients, potentially leading to improved surgical methods preserving palatal sensation.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Ryoki Sasaki, Sho Kojima, Naofumi Otsuru, Hirotake Yokota, Kei Saito, Hiroshi Shirozu, Hideaki Onishi
Summary: This study investigated the mechanisms of cortical connections in adult tactile perception and found that the connections within the somatosensory cortex and between different somatosensory cortices are related to tactile spatial acuity. This is the first study to demonstrate the functional support of specific cortical networks for tactile spatial acuity.
Review
Clinical Neurology
Marko Mijic, Andres Jung, Benedikt Schoser, Peter Young
Summary: This study systematically reviewed the role of peripheral electrical stimulation (PES) in changing somatosensory evoked potentials (SEP) in healthy subjects and stroke patients. The results suggest a correlation between sensory and motor function assessments and changes in SEP components. However, further randomized controlled trials are needed to verify the relationship between SEP, sensory reorganization, and cortical plasticity.
FRONTIERS IN NEUROLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Michael S. Beauchamp, William H. Bosking, Denise Oswalt, Daniel Yoshor
Summary: The study successfully implanted an electrode array with 96 penetrating electrodes in the visual cortex of a blind patient, allowing the patient to perceive visual patterns created by passing current through array electrodes. Penetrating electrodes require less current to create a visual percept compared to electrodes resting on the cortical surface, but patterned electrical stimulation often fails to produce the expected percept, necessitating further research to understand the relationship between stimulus and perception.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Physiology
Thierry Paillard
Summary: Percutaneous electrical stimulation is a method used to improve functional capabilities in older individuals. The specific physiological needs of the individual determine whether neuromuscular electrical stimulation (NMES) or sensory electrical stimulation (SES) is most appropriate. NMES enhances muscle strength and motor output, while SES facilitates sensorimotor activity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Clinical Neurology
Piia Lonnberg, Elina Pihko, Leena Lauronen, Jussi Nurminen, Sture Andersson, Marjo Metsaranta, Aulikki Lano, Paivi Nevalainen
Summary: In extremely preterm born (EPB) children, absence of secondary somatosensory cortex (SII) response at term-equivalent age correlated with poorer motor outcome at age 6. However, there was no significant difference in SII responses between EPB and term-born (TB) children at age 6. Motor inhibition was associated with decreased SII peak latencies in TB children, but this effect was lacking in EPB children.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Dat Le Cong, Daisuke Sato, Koyuki Ikarashi, Tomomi Fujimoto, Genta Ochi, Koya Yamashiro
Summary: The study investigated the effects of whole-hand water flow stimulation on the neural balance in the somatosensory cortex (S1), finding that this stimulation led to decreased neural inhibition in participants with higher neural inhibition at baseline. However, the study suggests that the duration of each intervention (15 minutes) may not be sufficient to significantly alter the balance of excitation and inhibition in the S1.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Yanlong Song, Emmanuelle Renoul, Stephanie Acord, Yvette R. Johnson, Warren Marks, George Alexandrakis, Christos Papadelis
Summary: Abnormal phase synchronizations were found within and between somatosensory areas in both hemispheres of children with hemiplegic cerebral palsy (HCP). The less-affected hemisphere showed diminished phase synchronizations after stimulus onset, while the more-affected hemisphere demonstrated enhanced phase synchronizations.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Harri Piitulainen, Timo Nurmi, Maria Hakonen
Summary: The early processing of proprioceptive afference in the primary sensorimotor cortex is modulated by attention. Attention to proprioception results in changes in the sensorimotor beta power, movement-evoked field amplitude, and corticokinematic coherence strength in healthy individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Matilde Forni, Palmi Thor Thorbergsson, Jonas Thelin, Jens Schouenborg
Summary: Developed a biocompatible microelectrode cluster to provide powerful and selective analgesia in awake rats without noticeable side effects. This method had minimal impact on gait, spontaneous cortical activity, and tactile responses, indicating a highly selective action.
Article
Clinical Neurology
Fengqiao Sun, Guojun Zhang, Liankun Ren, Tao Yu, Zhiwei Ren, Runshi Gao, Xiaohua Zhang
Summary: The study reveals the somatotopical characteristics of the entire human primary somatosensory cortex and identifies several previously unreported body-part representations in the sulcal cortex, such as forehead, deep elbow and wrist joints. The results extend the scope of the classical homunculus.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Hideo Ohba, Kei Nakagawa, Koji Iida, Louis Yuge
Summary: This study used magnetoencephalography to investigate sensory information processing after finger movement. The results showed that the sensitivity of the primary somatosensory cortex increased after completing a motor task.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Shikha Spencer, Marzena Mielczarek, Jurek Olszewski, Magdalena Sereda, Iris Joossen, Hanne Vermeersch, Annick Gilles, Sarah Michiels
Summary: The aim of this study was to evaluate the feasibility and efficacy of non-invasive bimodal auditory-somatosensory stimulation in reducing tinnitus severity among a general population of people with subjective tinnitus. The results showed that the bimodal stimulation is a feasible and safe method of tinnitus treatment, with a statistically significant decrease in tinnitus severity. However, further research is needed to establish the optimal treatment protocol and inclusion criteria.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Shigeki Kameyama, Hiroshi Masuda, Hiroshi Shirozu
Summary: The study found that multiple trajectories passing through the genu of the internal capsule were associated with emotional facial paresis, while a single trajectory had lower relevance to EFP. These results supported the hypothesis that the emotional corticobulbar tract passes through the genu of the internal capsule.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Pediatrics
Yui Shiroshita, Hikari Kirimoto, Mio Ozawa, Tatsunori Watanabe, Hiroko Uematsu, Keisuke Yunoki, Ikuko Sobue
Summary: The study reviewed the use of event-related potential (ERP) evoked by heel lance in neonates as an index of pain assessment and found potential problems including the possible activation of non-noxious stimuli-responsive A beta fibers instead of noxious-stimuli-responsive A delta or C fibers. Further research is needed to clarify the efficacy of using ERP evoked by heel lance as a pain assessment index in neonates.
Article
Neurosciences
Takuya Matsumoto, Tatsunori Watanabe, Takayuki Kuwabara, Keisuke Yunoki, Xiaoxiao Chen, Nami Kubo, Hikari Kirimoto
Summary: Our study found that SICI in the ipsi-M1 is decreased during visually guided finger movements compared to rest condition. Additionally, both SICI and LICI were smaller in the right M1 compared to the left M1, regardless of task conditions.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Neurosciences
Sho Kojima, Naofumi Otsuru, Shota Miyaguchi, Hirotake Yokota, Kazuaki Nagasaka, Kei Saito, Yasuto Inukai, Hiroshi Shirozu, Hideaki Onishi
Summary: The study revealed that the effects of repetitive mechanical tactile stimulation on somatosensory evoked magnetic fields and cortical oscillations depend on the patterns of tactile stimuli. Different patterns of stimulation elicited different cortical responses, showing potential for modulation of tactile functions based on cortical states.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sumiya Shibata, Tatsunori Watanabe, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Sachimori Ichimura, Hikari Kirimoto, Tatsuya Mima
Summary: Transcranial static magnetic stimulation (tSMS) over the left primary motor cortex (M1) for 20 min modulates local cortical activity and interregional functional coupling in the theta band, suggesting its potential role in inducing neural oscillations and neurophysiological effects in the frontal cortex.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Hiroshi Shirozu, Hiroshi Masuda, Shigeki Kameyama
Summary: The study indicated that seizure outcomes in patients with hypothalamic hamartoma following stereotactic radiofrequency thermocoagulation showed significant improvement for gelastic seizures (GS), but not for other types of seizures (nGS), which may be related to the independence of secondary epileptogenesis from surgical factors.
Article
Clinical Neurology
Shinsaku Yoshitomi, Shin-ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki, Yushi Inoue
Summary: The study reveals the challenging neurological, physical and developmental aspects, as well as intractable seizures, in patients with West syndrome. More than a half of the children showed developmental delay after onset, even though seizures were reduced during the course of the disease.
EPILEPTIC DISORDERS
(2021)
Article
Clinical Neurology
Yushi Inoue, Shin-ichiro Hamano, Masaharu Hayashi, Hiroshi Sakuma, Shinichi Hirose, Atsushi Ishii, Ryoko Honda, Akio Ikeda, Katsumi Imai, Kazutaka Jin, Akiko Kada, Akiyoshi Kakita, Mitsuhiro Kato, Kensuke Kawai, Tamihiro Kawakami, Katsuhiro Kobayashi, Toyojiro Matsuishi, Takeshi Matsuo, Shin Nabatame, Nobuhiko Okamoto, Susumu Ito, Akihisa Okumura, Akiko Saito, Hideaki Shiraishi, Hiroshi Shirozu, Takashi Saito, Hidenori Sugano, Yukitoshi Takahashi, Hitoshi Yamamoto, Tetsuhiro Fukuyama, Ichiro Kuki
Summary: This study examined the medical and psychosocial status of patients with epilepsy in Japan to assess the application of the Intractable/Rare Diseases Act. The majority of epilepsy patients met the severity criteria defined by the Act, but some groups had lower proportions due to successful surgical therapy. The study suggests that further research is needed to update the list of designated syndromes/diseases in the Act.
EPILEPTIC DISORDERS
(2022)
Review
Clinical Neurology
Hiroshi Masuda, Hiroshi Shirozu, Yosuke Ito, Masafumi Fukuda, Yukihiko Fujii
Summary: Deep brain stimulation (DBS) is an effective treatment for drug-resistant involuntary movements. Traditional leads cause unintended effects, but directional leads provide targeted stimulation. However, programming becomes more complex with directional leads.
NEUROLOGIA MEDICO-CHIRURGICA
(2022)
Article
Clinical Neurology
Hiroshi Shirozu, Hiroshi Masuda, Shigeki Kameyama
Summary: This study evaluated the feasibility of a new approach, SRT-TT, for disconnecting bilateral hypothalamic attachments in epileptic hypothalamic hamartomas (HHs). The results showed that SRT-TT could reduce the invasiveness of reoperation and minimize damage to the contralateral hypothalamus.
Article
Multidisciplinary Sciences
Takayuki Horinouchi, Tatsunori Watanabe, Takuya Matsumoto, Keisuke Yunoki, Takayuki Kuwabara, Kanami Ito, Haruki Ishida, Hikari Kirimoto
Summary: Prior knowledge of color can influence reaction times. In a Go/No-go task with an LED lighting device, reaction times were longer when responding to a red signal and withholding the response to a blue signal compared to when responding to a blue signal and withholding the response to a red signal. This study found that the effect of prior knowledge on reaction times was not significant in signals presented on an LCD monitor, but it was significant when presented on an LED lighting device.
Article
Multidisciplinary Sciences
Keisuke Yunoki, Tatsunori Watanabe, Takuya Matsumoto, Takayuki Kuwabara, Takayuki Horinouchi, Kanami Ito, Haruki Ishida, Hikari Kirimoto
Summary: This study aimed to investigate the difference in cutaneous information processing between position and force tasks during static muscle contraction. The results demonstrated that the reduction of somatosensory evoked potentials (SEPs) amplitude was significantly larger in the force task, and the amplitude of cutaneomuscular reflex (CMR) was greater in the force task as well.
Article
Physiology
Kanami Ito, Tatsunori Watanabe, Takayuki Horinouchi, Takuya Matsumoto, Keisuke Yunoki, Haruki Ishida, Hikari Kirimoto
Summary: Synchronous finger tapping to external sensory stimuli is more stable for audiovisual combined stimuli than sole auditory or visual stimuli. Piano players show superior synchronization stability and motor control compared to novices. Improvements in sensorimotor processing and finger motor control by piano practice contribute to superior synchronization stability.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2023)
Article
Multidisciplinary Sciences
Takefumi Higashijima, Hiroshi Shirozu, Hirotomo Saitsu, Masaki Sonoda, Atsushi Fujita, Hiroshi Masuda, Tetsuya Yamamoto, Naomichi Matsumoto, Shigeki Kameyama
Summary: This study found that patients with Hypothalamic hamartoma (HH) and mutations of Shh-related genes show hippocampal maldevelopment and abnormal hippocampal infolding angle (HIA). The HIA can be used as an indicator of abnormalities in the Shh signaling pathway.
Article
Clinical Neurology
Mitsuyoshi Nakatani, Morito Inouchi, Masako Daifu-Kobayashi, Tomohiko Murai, Jumpei Togawa, Shunsuke Kajikawa, Katsuya Kobayashi, Takefumi Hitomi, Takeharu Kunieda, Satoka Hashimoto, Motoki Inaji, Hiroshi Shirozu, Kyoko Kanazawa, Masaki Iwasaki, Naotaka Usui, Yushi Inoue, Taketoshi Maehara, Akio Ikeda
Summary: This study aimed to evaluate the utility of EEG analysis in epilepsy surgery. The results showed that ictal direct-current shifts were more frequently detected in the seizure-onset zone compared to ictal high-frequency oscillations, and the complete resection of the core area of ictal direct-current shifts was associated with favorable surgical outcomes.
BRAIN COMMUNICATIONS
(2022)
