Article
Clinical Neurology
Emma C. Argaet, Belinda Y. C. Kwok, Justine Bradley, Allison S. Young, Benjamin Nham, Zeljka Calic, Rachael L. Taylor, Jacob M. Pogson, Nicole Reid, Jonathan H. K. Kong, Sean Flanagan, Gabor M. Halmagyi, Sally M. Rosengren, Miriam S. Welgampola
Summary: This study aimed to investigate the relationship between two widely used otolith function tests, Subjective Visual Horizontal (SVH) and Vestibular Evoked Myogenic Potentials (VEMP). A retrospective analysis of 301 patients showed that SVH had a significant moderate correlation with bone-conducted oVEMP, and a weak correlation with air-conducted cVEMP. This finding supports the hypothesis of a common utricular origin for both SVH and oVEMPs.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jinying Zhang, Lichao Ye, Xuefeng Bai, Yali Huang, Jiayu Lin, Huapin Huang
Summary: Diabetic peripheral neuropathy may lead to vestibular dysfunction, and VEMP can be a useful tool for assessing vestibular impairment in these patients.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Otorhinolaryngology
V. P. Thirusangu, S. K. Sinha
Summary: This study investigated the masseter vestibular-evoked myogenic potential in healthy adults using clicks and 500 Hz tone burst stimuli. The results showed that the amplitude of the p11-n21 complex was higher for 500 Hz tone burst than for click stimulus, and bilateral stimulation elicited a larger response than ipsilateral and contralateral stimulation.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2023)
Article
Otorhinolaryngology
Maristela Mian Ferreira, Karen de Carvalho Lopes, Thais Alvares de Abreu e Silva Grigol, Mauricio Malavasi Gananc, Heloisa Helena Caovilla
Summary: This study aimed to evaluate otolith function in patients with unilateral definite Meniere's disease during the inter-crisis period by comparing the findings of the Subjective Visual Vertical, the cervical Vestibular Evoked Myogenic Potential, and the ocular Vestibular Evoked Myogenic Potential tests. The results showed no significant difference among these tests, indicating concordance.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Jessie N. Patterson, Amanda I. Rodriguez, Katherine R. Gordon, Julie A. Honaker, Kristen L. Janky
Summary: Age significantly influenced the amplitudes of cervical and ocular VEMPs regardless of stimulus type (ACS, B81, IH). All stimuli are suitable for eliciting c- and oVEMPs in young individuals, while ACS resulted in higher cVEMP corrected amplitudes in older individuals. IH showed higher response rates and larger amplitudes for oVEMPs, followed by B81 and ACS. Overall, the B81 performed well across the lifespan for c- and oVEMPs, but may not be a replacement for ACS.
Article
Pharmacology & Pharmacy
Sherifa Ahmed Hamed, Amira Mohamed Osiely
Summary: Vestibular dysfunctions are common in children with epilepsy, with bilateral peripheral dysfunction being more prevalent than central dysfunction, suggesting a potential adverse effect of valproate on the vestibular system.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Imelda P. Hannigan, Benjamin Nham, Chao Wang, Sally M. Rosengren, Belinda Y. C. Kwok, Leigh A. McGarvie, Nicole M. Reid, Ian S. Curthoys, Gabor Michael Halmagyi, Miriam S. Welgampola
Summary: This study found a significant correlation between the subjective visual horizontal (SVH) and ocular-VEMPs (oVEMPs) in patients with acute vestibular neuritis, suggesting that both tests can assess otolith function.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Clinical Neurology
Dietrich Klunk, Timo B. Woost, Christopher Fricke, Joseph Classen, David Weise
Summary: This study investigated VEMP to differentiate between Parkinson's disease (PD) and atypical parkinsonism (AP). The results showed that oVEMP and balance assessments may be differentially affected in PD and AP, with cVEMP not showing significant differences. Balance assessment and oVEMP could be implemented in the differential diagnostic work up of parkinsonian syndromes.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sarah Hosli, Dominik Straumann
Summary: The study indicates that the relationships among oVEMPs, SVV, and BCR in assessing utricular function are complex, with no correlation between oVEMP and SVV, and a high correlation between SVV and BCR.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jiali Shen, Lu Wang, Xiaobao Ma, Zichen Chen, Jianyong Chen, Xueyan Wang, Kuan He, Wei Wang, Jin Sun, Qin Zhang, Min Shen, Xiangping Chen, Qing Zhang, Kimitaka Kaga, Maoli Duan, Jun Yang, Yulian Jin
Summary: The study compared the features of air-conducted sound cervical vestibular evoked myogenic potential (ACS-cVEMP) and bone-conducted vibration cVEMP (BCV-cVEMP) between infants and healthy adults, suggesting that combining both methods can improve the accuracy of infant vestibular screening.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Feray Gulec Uyaroglu, Roza Ucar, Ahmet Acarer, Nese Celebisoy
Summary: In this study, cervical vestibular-evoked myogenic potentials (cVEMPs) were studied in essential tremor (ET) patients to explore the interaction between the tremor network and the vestibular neural pathways. The results showed that cVEMP responses were affected in ET patients, which could be caused by dysfunctional structures or pathways responsible for ET, or an additional disorder of vestibular information processing in these patients.
NEUROLOGICAL SCIENCES
(2021)
Review
Neurosciences
Wenqi Cui, Zhenghao Duan, Juan Feng
Summary: A meta-analysis revealed abnormal findings of vestibular-evoked myogenic potentials in patients with Parkinson's disease, suggesting dysfunction of the brainstem in PD.
Article
Clinical Neurology
Sandra Carpinelli, Philipp O. Valko, Daniel Waldvogel, Elena Buffone, Christian R. Baumann, Dominik Straumann, Esther Werth, Christopher J. Bockisch, Konrad P. Weber, Yulia Valko
Summary: The study found that the central vestibular pathways were more severely damaged in PSP patients compared to PD patients, as indicated by higher VEMP scores in PSP. There were meaningful correlations between VEMPs and motor and non-motor symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Francesca Cianfrone, Italo Cantore, Raffaelino Roperto, Francesco Tauro, Francesco Bianco, Luciano Mastronardi, Paolo Ruscito
Summary: This study introduces a method to accurately predict the nerve branch of origin of vestibular schwannoma through preoperative testing. The results show that preoperative audiological and vestibular evaluation can predict the vestibular tumor branch of origin with high accuracy. These findings may change the preoperative approach and counseling with the patients.
NEUROSURGICAL REVIEW
(2022)
Review
Clinical Neurology
Estelle Nakul, Fabrice Bartolomei, Christophe Lopez
Summary: This article reviews studies on vestibular evoked potentials (EPs) using various methods of vestibular stimulation, revealing the spatiotemporal dynamics of vestibular information processing. Results show short, middle, and late latency EPs, with generator analysis providing new insights into the neuroimaging of the vestibular system.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
Amir H. Talebi, Jan H. L. Ypinga, Nienke M. De Vries, Jorik Nonnekes, Marten Munneke, Bas R. Bloem, Tom Heskes, Yoav Ben-Shlomo, Sirwan K. L. Darweesh
Summary: Specialized physiotherapy and occupational therapy can reduce the incidence rate of Parkinson's disease-related complications. There may be a synergistic effect among multiple specialized allied health disciplines. The findings of this study support the introduction of specialized allied health therapy expertise in Parkinson's disease care.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Milan Beckers, Bastiaan R. Bloem, Rick C. Helmich
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Anneli Langbroek-Amersfoort, Sabine Schootemeijer, Lars Bouten, Bastiaan R. Bloem, Nienke M. De Vries
Summary: There is increasing evidence supporting the positive effects of community-based exercise for individuals with Parkinson's disease. However, the studies on this topic vary greatly in terms of exercise types, study designs, and outcome measures. While this review acknowledges the feasibility and potential benefits of community-based exercise, it also emphasizes the need for improvement in the overall quality of these studies.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Article
Clinical Neurology
Dijana Nuic, Sjors van de Weijer, Saoussen Cherif, Anna Skrzatek, Eline Zeeboer, Claire Olivier, Jean-Christophe Corvol, Pierre Foulon, Jenica Z. Pastor, Gregoire Mercier, Brian Lau, Bastiaan R. Bloem, Nienke M. De Vries, Marie-Laure Welter
Summary: This study aimed to evaluate the efficacy of a home-based training system using a tailored exergame for patients with Parkinson's disease (PD) to improve gait and balance disorders. The results showed that home-based training using a tailored exergame can be performed safely by PD patients and could potentially improve gait and balance disorders.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Neurosciences
Federica Albanese, Bastiaan R. Bloem, Lorraine V. Kalia
Summary: Metascience emphasizes the importance of replication, reproducibility, and rigor in research, particularly in studying major diseases like Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Editorial Material
Clinical Neurology
Tessa F. Peerbolte, Rozanne J. A. van Diggelen, Marjan J. Meinders, Bastiaan R. Bloem, Sanne W. van den Berg
PRACTICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Milan Beckers, Peter J. Koehler, Geert J. A. Wanten, Bastiaan R. Bloem
Summary: There is a hypothesis suggesting that Adolf Hitler had Parkinson's disease and suffered from gastrointestinal symptoms, possibly linked to small-intestinal bacterial overgrowth (SIBO), serving as an early indication of Parkinson's.
EUROPEAN NEUROLOGY
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)