Review
Pharmacology & Pharmacy
Thiruventhan Karunakaran, Kok Zhuo Ngew, Ahmad Alif Danial Zailan, Vivien Yi Mian Jong, Mohamad Hafizi Abu Bakar
Summary: Mitragynine is a naturally occurring indole alkaloid extracted from the leaves of the medicinal plant Mitragyna speciosa, which shows promising analgesic effects with limited adverse effects compared to morphine. This review discusses the pharmacological and toxicological properties of mitragynine and its diastereomers, speciogynine, speciociliatine, and mitraciliatine, and explores the structure-activity relationship of these compounds.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Yuqian Zhu, Jinran Zhao, Longbiao Luo, Yang Gao, He Bao, Pengfei Li, Hailong Zhang
Summary: Indole alkaloids play an important role in natural products due to their versatile biological activities, which are a potential source for novel antidiabetic drugs. The synthesized indole derivatives possess properties similar to natural indole alkaloids. In recent years, more and more indole derivatives have been designed and synthesized for exploring their bioactivities.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Ke Liu, Bixia Hong, Shuqi Wang, Fuxing Lou, Yecheng You, Ruolan Hu, Amna Shafqat, Huahao Fan, Yigang Tong
Summary: Cepharanthine, a natural bisbenzylisoquinoline alkaloid, is the only approved drug of its kind for human use. It has been used in the clinic for over 70 years and has various medicinal properties, including anti-tumor, anti-inflammatory, anti-pathogen activities, among others. Recently, it has been found to greatly inhibit SARS-CoV-2 infection. This article provides a comprehensive description of the pharmacological properties, mechanisms, safety, and potential clinical applications of cepharanthine, highlighting its potential as a drug for the treatment of different diseases.
Article
Chemistry, Organic
Hao-Feng Zhou, Wen-Yan Li, Li-Yan Peng, Xiao-Nian Li, Zhi-Li Zuo, Qin-Shi Zhao
Summary: Five new indole alkaloids, Rhynchines A-E, with a unique skeleton structure were isolated from Uncaria rhynchophylla. Among them, compounds 1 and 2 showed strong inhibitory activities against the Ca-v 3.1 calcium channel.
Article
Chemistry, Organic
Tape Kouame, Guillaume Bernadat, Victor Turpin, Marc Litaudon, Aboua Timothee Okpekon, Jean-Francois Gallard, Karine Leblanc, Somia Rharrabti, Pierre Champy, Erwan Poupon, Mehdi A. Beniddir, Pierre Le Pogam
Summary: Melonine is a basic monoterpene indole alkaloid (MIA) skeleton from Melodinus philliraeoides, with its structure revised into an unprecedented MIA scaffold. Proposed DFT-validated biosynthetic paths to both this new core and the originally reported form suggest the thermodynamic feasibility of the original structure of melonine, indicating its potential existence as a natural product.
Article
Chemistry, Organic
Eunjoon Park, Cheolwoo Bae, Cheon-Gyu Cho, Cheol-Hong Cheon
Summary: The total syntheses of the antirhine alkaloids were achieved through a series of reactions, including the cyanide-catalyzed imino-Stetter reaction and subsequent C-ring formation to generate the key intermediate. The trans-selective installation of the homoallylic alcohol side-chain at C-15 allowed the successful total syntheses of antirhine and its known epimer.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Francisco Leon, Samuel Obeng, Marco Mottinelli, Yiming Chen, Tamara King, Erin C. Berthold, Shyam H. Kamble, Luis F. Restrepo, Avi Patel, Lea R. Gamez-Jimenez, Carolina Lopera-Londono, Takato Hiranita, Abhisheak Sharma, Aidan J. Hampson, Clinton E. Canal, Lance R. McMahon, Christopher R. McCurdy
Summary: Research showed that kratom alkaloids have effects on serotonin receptors in vitro and in vivo, with paynantheine and speciogynine exhibiting high affinity for 5-HT(1A)Rs and 5-HT(2B)Rs. These alkaloids can produce antinociceptive properties through a mechanism independent of opioid receptors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Plant Sciences
Si-Fan Teng, Fang-Ru Li, Qi-Min Cui, Afsar Khan, Ting He, Xiao-Dong Luo, Ya-Ping Liu, Gui-Guang Cheng
Summary: Indole alkaloids are diverse natural products in plants with significant biological effects on human health. The genus Melodinus is rich in mono- and bis-indole alkaloids, which have been traditionally used for various medical purposes. This article provides a comprehensive review on the phytochemical diversity and pharmacological effects of indole alkaloids from Melodinus species. A total of 345 indole alkaloids have been reported, exhibiting cytotoxic, antimicrobial, anti-inflammatory, antifungal, and antioxidant activities. The review aims to promote further development and utilization of Melodinus species.
PHYTOCHEMISTRY REVIEWS
(2023)
Review
Integrative & Complementary Medicine
Mi Li, Li Yu-Chen, Sun Meng-Ru, Zhang Pei-Lin, Li Yi, Yang Hua
Summary: Aconitum alkaloids, extracted from Aconitum plants, have complex chemical structures and significant biological activity. They show a wide range of pharmacological activities, including protecting the cardiovascular system, nervous system, and immune system, as well as anti-cancer effects. However, they also exhibit strong cardiac toxicity, neurotoxicity, and liver toxicity, supported by clinical studies.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Plant Sciences
Rui Guo, Jian-Hua Shang, Rui-Han Ye, Yun-Li Zhao, Xiao-Dong Luo
Summary: This study confirms the potential therapeutic effect of alkaloids from A. scholaris on chronic glomerulonephritis (CGN). By regulating four key proteins (HRAS, CDK2, HSP90AA1, and KDR) of the PI3K-Akt pathway, TA and two major bioactive components (vallesamine and 19-epi-scholaricine) can exert protective effects against ADR-induced CGN in the MPC5 cells model.
Article
Chemistry, Organic
Jiahang Yan, Yanxia Zhen, Pengyan Wang, Yimeng Han, Huanhuan Zou, Junhan Chen, Weigang He, Weiqing Xie
Summary: In this study, a de novo synthesis of the bisindole alkaloid geissolosimine was accomplished, along with the synthesis of related compounds and the demonstration of an innovative strategy. These findings provide new insights for further research.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Matteo Faltracco, Said Ortega-Rosales, Elwin Janssen, Razvan C. Cioc, Christophe M. L. Vande Velde, Eelco Ruijter
Summary: The unexpected discovery in a seemingly trivial reaction led to the selective formation of a new carbazole product. This reaction, by carefully varying substituents, revealed a complex cascade mechanism with at least 10 elementary steps that could be directed towards different carbazole derivatives.
Article
Chemistry, Organic
Chao Liu, Luc Van Meervelt, Vsevolod A. Peshkov, Erik V. Van der Eycken
Summary: A novel gold-catalyzed hydroarylation/Michael addition process has been developed for the efficient construction of benzazepinoindole polycyclic scaffolds from readily accessible multifunctional Ugi adducts. The developed methodology exhibits a broad substrate scope, excellent functional-group tolerance, and high yields of the target benzazepinoindoles.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Medicinal
Joko Tri Wibowo, Peni Ahmadi, Siti Irma Rahmawati, Asep Bayu, Masteria Yunovilsa Putra, Anake Kijjoa
Summary: Novel secondary metabolites from marine macroorganisms and marine-derived microorganisms have been extensively studied. Indole alkaloids, as one of the most promising compounds, possess diverse biological/pharmacological activities. This review summarizes the indole alkaloids isolated from 2016 to 2021 and their relevant biological/pharmacological activities, describing a total of 186 indole alkaloids.
Review
Plant Sciences
Christian Bailly
Summary: The genus Ruta in the family Rutaceae includes about 40 species, including well-known plants such as common rue and fringed rue, as well as lesser-known species like narrow-leaved fringed rue. The narrow-leaved fringed rue, originating from the Mediterranean region, is well-distributed in Southeast Asia and is used in some countries to treat liver diseases and cancer. Extracts of this plant have antifungal, antiviral, and antiparasitic effects.
Review
Food Science & Technology
Saikat Mitra, Abu Montakim Tareq, Rajib Das, Talha Bin Emran, Firzan Nainu, Arka Jyoti Chakraborty, Islamudin Ahmad, Trina E. Tallei, Abubakr M. Idris, Jesus Simal-Gandara
Summary: This review discusses the synergistic interactions and specific health benefits of polyphenolic compounds, as well as their bioavailability in humans. The toxicity of some polyphenols is also evaluated. Synergistic treatment approaches using polyphenols may be effective in the treatment of various diseases.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Food Science & Technology
Tiantian Tian, Hui Cao, Mohamed Ali Farag, Siting Fan, Luxuan Liu, Wenjing Yang, Yuxuan Wang, Liang Zou, Ka-Wing Cheng, Mingfu Wang, Xiaolei Ze, Jesus Simal-Gandara, Chao Yang, Zhiwei Qin
Summary: This article summarizes the bioactive compounds in Prunus mume fruit and their potential applications in nutrition and medicine. Prunus mume exhibits various functional properties, including antioxidant, anticancer, antimicrobial, and hormone regulatory effects, but further research is needed to uncover its additional nutritional and functional therapeutic mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Gamal M. Hamad, Taha Mehany, Jesus Simal-Gandara, Sarah Abou-Alella, Okon J. Esua, Mosaad A. Abdel-Wahhab, Elsayed E. Hafez
Summary: Mycotoxin contamination is a significant threat to food safety and quality, and conventional methods for detoxification face challenges. Innovative strategies such as cold atmospheric plasma, polyphenols and flavonoids, magnetic materials and nanoparticles, and natural essential oils show promising potential for mycotoxin control. However, complete decontamination has not been achieved, and integrated management systems combining multiple strategies may be explored for higher efficiency and adaptability.
Article
Biochemistry & Molecular Biology
Reem M. Gahtani, Ali Alqahtani, Taha Alqahtani, Saeed Ahmed Asiri, Jamal Moideen Muthu Mohamed, S. Venkatesa Prabhu, Endalew Yaze Muluneh
Summary: The aim of this investigation was to develop polymeric nanoparticles (NPs) for intravenous drug delivery of 5-fluorouracil (FU) to improve its therapeutic effectiveness. The effectiveness of FU integration into NPs was influenced by the technique used to prepare the organic phase and the ratio of the organic phase to the aqueous phase. The integration of FU into NPs significantly increased its cytotoxic effect compared to the marketed formulation Fluracil (R).
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2023)
Article
Chemistry, Physical
Monika Bhattu, Aabid A. Wani, Meenakshi Verma, P. V. Bharatam, Deepika Kathuria, Jesus Simal-Gandara
Summary: In this study, eco-friendly organic nanoparticles were successfully synthesized with a size range of 15-20 nm. These nanoparticles demonstrated both U.V. visible and fluorescence responses for the selective detection of the hazardous pesticide azinphos-methyl in aqueous media. Additionally, these organic nanoparticles showed selective fluorescence responses in RO water, tap water, and orange juice. FT-IR and DFT studies helped identify the specific H-bonding interactions responsible for the selective detection of Azinphos-methyl.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Letter
Surgery
Hitesh Chopra, Mohamed S. Attia, Syed Faisal Badshah, Kuldeep Dhama, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Hitesh Chopra, Neil Patel, Yashendra Sethi, Talha B. Emran
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Diah Kusumawaty, Stella Melbournita Noor Augustine, Any Aryani, Yunus Effendi, Talha Bin Emran, Trina Ekawati Tallei
Summary: This study aimed to explore the bacterial communities in the digestive tracts of wild and cultivated Indonesian shortfin eel during the elver phase. The results showed that the microbiota in the eel's digestive tract was diverse and played a significant role in nutrient absorption. The findings of this study can contribute to assessing eel health and improving eel farming conditions.
Letter
Medicine, General & Internal
Soumeia Zeghoud, Deepak Chandran, Ilham Ben Amor, Hadia Hemmami, Pran Mohankumar, Talha Bin Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Infectious Diseases
Popat Mohite, Ramdas Pandhare, Nobendu Mukerjee, Rohit Sharma, Abhijit Dey, Ranjan K. Mohapatra, Snehasish Mishra, Ashish K. Sarangi, Bijaya K. Padhi, Ranjit Sah
NEW MICROBES AND NEW INFECTIONS
(2023)
Review
Chemistry, Applied
Prabhakar Semwal, Sakshi Painuli, J. P. Shabaaz Begum, Abhishek Jamloki, Abdur Rauf, Ahmed Olatunde, Md. Mominur Rahman, Nobendu Mukerjee, Anees Ahmed Khalil, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Jesus Simal-Gandara
Summary: Pulses have been consumed globally for centuries and are widely used as a food source due to their economic and nutritional benefits. They are rich in protein, fiber, vitamins, and minerals, and can have positive effects on cardiovascular health. However, their use is mostly limited to certain regions. This comprehensive review provides information on the chemical and nutritional properties, health effects, accessibility, and agricultural productivity of various pulse crops grown in the Indian Himalayan Region.
Article
Chemistry, Multidisciplinary
Dhiss Tesnim, Ben Amor Hedi, Jesus Simal-Gandara
Summary: In this study, an innovative green catalyst was used for the removal of Crocein Orange G dye from aqueous solution. The clay bentonite El Hamma-supported nanoscale zero-valent iron was employed as a heterogeneous Fenton-like catalyst, and palm waste extract was used for the synthesis of the catalyst. The results showed that this catalyst achieved total degradation of the dye within 180 minutes, and the degradation efficiency remained high even after three successive runs. This study provides a sustainable and effective method for azoic dye removal from industrial wastewaters.
Article
Food Science & Technology
Shiye Lin, Jesus Simal-Gandara, Hui Cao, Jianbo Xiao
Summary: Polyhydroxy flavonols are easily degraded during thermal processing. This study used UPLC-Q-tof-MS/MS to investigate the stability of dietary polyhydroxy flavonols, including myricetin, kaempferol, galangin, fisetin, myricitrin, quercitrin, and rutin, in boiling water. The degradation of flavonols mainly resulted from the opening of the heterocyclic ring C to form simpler aromatic compounds. The degradation products included 1,3,5-benzenetriol, 3,4,5-trihydroxybenzoic acid, 2,4,6-trihydroxybenzoic acid, and 2,4,6-trihydroxybenzaldehyde, among others. The presence of glycosides in myricitrin slightly affected its stability, while the glycosides in rutin and quercitrin significantly improved their stability in water. During boiling, flavonols underwent various chemical reactions, such as hydroxylation, dehydroxylation, deglycosidation, deprotonation, and C-ring cleavage.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Letter
Surgery
Hitesh Chopra, Talha B. Emran, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Microbiology
Surya Prakash Sharma, Sujata Dwivedi, Sunil Kumar, Kuldeep Dhama, Anil Kumar Sharma
Summary: Infectious keratitis is a major cause of blindness worldwide. Recent studies have found that contact lens usage, ocular injuries, and ocular surface disease are primary risk factors for keratitis. Advanced imaging techniques and molecular detection methods are more effective than traditional culture methods in rapidly and accurately diagnosing infectious keratitis.
CURRENT CLINICAL MICROBIOLOGY REPORTS
(2023)