Review
Chemistry, Analytical
Alvaro Santana-Mayor, Ruth Rodriguez-Ramos, Antonio Herrera-Herrera, Barbara Socas-Rodriguez, Miguel Angel Rodriguez-Delgado
Summary: The development of sustainable chemistry has led to the emergence of new materials, with deep eutectic solvents (DESs) as a promising non-toxic alternative to toxic organic solvents, seeing a significant increase in their applications in analytical chemistry in recent years. The vast amount of information generated from studies associated with DESs needs continuous revision.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
Jean-Baptiste Chagnoleau, Ines L. D. Ryan, Ryan Khedher, Joao AP Coutinho, Thomas Michel, Xavier Fernandez, Nicolas Papaiconomou
Summary: A study was conducted on ternary biphasic systems composed of heptane, 1-butanol or ethyl acetate, and type III or type V deep eutectic solvents based on levulinic acid and choline chloride or thymol. The binodal curves, densities, and phase compositions of the equilibrium phases were determined for seven systems. The partition coefficients of six natural compounds were measured in these systems. Based on the results, a system composed of heptane, 1-butanol, and the deep eutectic solvent choline chloride:levulinic acid at a molar ratio of 1:3 was selected for centrifugal partition chromatography and showed good separation of apigenin, coumarin, beta-ionone, and alpha-tocopherol.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Maria Angeles Garcia, Sara Jimenez-Jimenez, Maria Luisa Marina
Summary: This work developed an Electrokinetic Chromatography (EKC) method that successfully separated the four stereoisomers of the acetamide herbicide dimethenamid. Different anionic cyclodextrins (CDs) were screened, and the use of a dual CD system improved the chiral separation. The addition of deep eutectic solvents showed beneficial effects on the separation in terms of resolution.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Multidisciplinary
Henrik Palmelund, Jukka Rantanen, Korbinian Lobmann
Summary: Deep eutectic solvents (DESs) are composed of a hydrogen bond donor and acceptor, and the interactions between them significantly lower the melting point of the mixture. Despite having eutectic melting temperatures above room temperature, all investigated DESs were able to appear liquid at room temperature under ambient conditions due to low RH0.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Chemical
Norafiqah Ismail, Jun Pan, Mahmoud Rahmati, Qian Wang, Denis Bouyer, Mohamed Khayet, Zhaoliang Cui, Naser Tavajohi
Summary: In this study, a new family of non-ionic deep eutectic solvents (NIDES) is proposed for membrane preparation, and high-performance PVDF membranes are efficiently prepared by dissolving PVDF polymer.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Fabian Thomas, Oliver Kayser
Summary: This study demonstrates the advantages of performing cannabinoid biotransformations in natural deep eutectic solvents (NADES), which significantly increase cannabinoid production. The research also suggests flexible manipulation of solvent compositions to enhance total cannabinoid content or alter cannabinoid specificity.
BIOCHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Maninder Meenu, Vasudha Bansal, Sudha Rana, Nitya Sharma, Vinod Kumar, Vaishali Arora, Monika Garg
Summary: Anthocyanins are extracted using alternative solvents such as ionic liquids, deep eutectic solvents, and natural deep eutectic solvents, which are more environmentally friendly and efficient compared to conventional solvents. Acid-based deep eutectic solvents with 20-30% water content showed the highest anthocyanin extraction yield. Ultrasonic-assisted extraction was the most common and efficient method, and DES-based extracts exhibited the highest stability and antioxidant activity. Fruits and their by-products are the most commonly used samples, while cereal and legumes are less explored.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2023)
Article
Biochemical Research Methods
Sergio M. Vilas-Boas, Isabella W. Cordova, Kiki A. Kurnia, Heloisa H. S. Almeida, Priscilla S. Gaschi, Joao A. P. Coutinho, Simao P. Pinho, Olga Ferreira
Summary: Countercurrent and centrifugal partition chromatography are techniques for separating compounds from natural extracts, with the selection of the biphasic solvent system being a key design parameter. COSMO-RS and NRTL-SAC models were used to estimate partition coefficients of phenolic compounds in different solvent systems, with the NRTL-SAC model showing higher reliability.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Biochemistry & Molecular Biology
Giovanni P. Rachiero, Paula Berton, Julia Shamshina
Summary: Innovative technologies can convert waste into raw materials, and biomass can be used as environmentally friendly solvents for utilization. This article summarizes the key role of deep eutectic solvents (DESs) in biomass waste valorization, including chitin extraction and separation of valuable chemicals and biofuels.
Review
Chemistry, Analytical
Vasil Andruch, Alica Varfalvyov, Radoslav Halko, Natalia Jatkowska, Justyna Plota Wasylk
Summary: This review summarizes the application of deep eutectic solvents (DESs) in bioanalysis. DESs have unique properties in terms of simplicity of preparation, designability, and low cost, and are widely used in sample preparation and analyte quantification, especially in various types of biological samples. DES-based methods have many advantages compared to traditional methods.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Jingyu Zhang, Shang Li, Liping Yao, Yuexing Yi, Lingqi Shen, Zuguang Li, Hongdeng Qiu
Summary: Deep eutectic solvents (DESs) have been recognized as a new type of green solvent with the potential to be used as customizable solvents. Switchable deep eutectic solvents (SDESs) have smart properties that can be switched by external driving forces, simplifying sample preparation steps and enabling the use of less organic solvents. This review summarizes the concept and research progress of SDESs, providing a reference for further research in analytical sample pretreatment.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Adriaan van den Bruinhorst, Margarida Costa Gomes
Summary: The study discusses the molecular origin of the large melting point depressions observed for deep eutectic solvents (DESs) and points out the lack of understanding about the relationship between DES liquid microstructure and macroscopic properties. The researchers call for experimental quantification of the observed balance between interactions and disorder at the molecular level and the incorporation of this data in thermodynamic models for calculation and prediction of solvation properties and eutectic depth.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2022)
Article
Engineering, Environmental
Maria F. Nava-Ocampo, Lamya Al Fuhaid, Robert Verpoorte, Young Hae Choi, Mark C. M. van Loosdrecht, Johannes S. Vrouwenvelder, Geert J. Witkamp, Andreia S. F. Farinha, Szilard S. Bucs
Summary: The study demonstrates that NADES can act as a biofilm structural breaker, solubilizing the main components of biofilms and weakening their structure, potentially serving as an environmentally-friendly green solvent for biofilm treatment.
Article
Chemistry, Multidisciplinary
Victor Gregorio, Piotr Jankowski, Nuria Garcia, Juan Maria Garcia Lastra, Pilar Tiemblo, Jin Hyun Chang
Summary: Gel polymer electrolytes composed of deep eutectic solvent acetamide(4):Zn(TFSI)(2) and poly(ethylene oxide) (PEO) are prepared using a fast, solvent-free method. The physicochemical and electrochemical properties of the electrolytes are influenced by the molecular weight and concentration of PEO. The addition of PEO can enhance the ionic conductivity and reduce dendritic growth in the soft gels.
Article
Electrochemistry
Renata Costa, Ana T. S. C. Brandao, Carlos M. Pereira, A. Fernando Silva
Summary: Many studies have focused on the physicochemical properties of ionic liquids (ILs), but less attention has been given to interfacial properties involving deep eutectic solvents (DES). The knowledge of DES-electrode interactions is lacking, which hinders the proposal of a suitable Electrical Double Layer model (EDL) for the description of DES at electrified interfaces. Measuring differential capacitance-potential curves is crucial for understanding the EDL structure and designing electrochemical systems. In this study, choline chloride-based DESs with different hydrogen bond donors (HBDs) were evaluated against different electrodes, and the differential capacitance-potential curves varied significantly depending on the electrode surface.
ELECTROCHIMICA ACTA
(2023)
Article
Agriculture, Multidisciplinary
Jose Perez-Navarro, Isidro Hermosin-Gutierrez, Sergio Gomez-Alonso, Aynur Kurt-Celebi, Nesrin Colak, Sema Hayirlioglu-Ayaz, Faik A. Ayaz, Erdal Akpinar
Summary: This study conducted a detailed profiling of non-anthocyanin phenolic fractions from 'Karaerik' table grape, revealing a high number of phenolic compounds and evaluating their antioxidant properties. Proanthocyanidins were found to be abundant in seeds with higher antioxidant capacity. These findings provide valuable information for promoting the varietal identity and health-related properties of this grape.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agronomy
Rita Astudillo-Neira, Evelyn Munoz-Nunez, Soledad Quiroz-Carreno, Jorge Avila-Stagno, Julio Alarcon-Enos
Summary: This study evaluated the bioconversion of ryegrass-fescue hay by solid state fermentation with Pleurotus ostreatus. After 14 days of fermentation, there was an increase in crude protein and non-fibrous carbohydrates, while neutral detergent fiber and acid detergent lignin decreased. Enzymatic activity measurements confirmed the biodegradation carried out by P. ostreatus.
Article
Biochemistry & Molecular Biology
Soledad Quiroz-Carreno, Evelyn Munoz-Nunez, Fabiana L. Silva, Luis Devotto-Moreno, David S. Seigler, Edgar Pastene-Navarrete, Carlos L. Cespedes-Acuna, Julio Alarcon-Enos
Summary: Cyclopeptide alkaloids present in plants of the family Rhamnaceae, such as Discaria chacaye, were studied to establish a connection with the presence of Frankia sp. The research identified 24 alkaloids, including cyclopeptides, and found that the presence of cyclopeptide alkaloids is associated with Frankia nodules. The alkaloid extracts also showed insecticidal activity.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Food Science & Technology
Sandra Tatiana Suescun-Ospina, Jorge Avila-Stagno, Nelson Vera-Aguilera, Rita Astudillo-Neira, Igor Trujillo-Mayol, Julio Alarcon-Enos
Summary: The study evaluates the effects of drying conditions on the chemical composition, bioactive compounds, and rumen fermentation parameters of Grape marc (GM) from Pais winery. The results show that oven-drying can preserve the chemical value of GM and extend its shelf-life, making it suitable for use as ruminant feed with potential positive environmental effects on enteric CH4 emissions. However, further in vitro and in vivo studies are required to assess the use of GM as a dietary ingredient.
Article
Agronomy
Carolina Tatagiba da Rocha Dadalto, Isidro Hermosin-Gutierrez, Jose Perez-Navarro, Rosa Maria Ojeda-Amador, Sergio Gomez-Alonso, Paulo Cesar Stringheta, Daniele de Almeida Paula, Marcos Roberto Moacir Ribeiro Pinto, Afonso Mota Ramos
Summary: This study assessed the phenolic composition of Jussara pulp from the Brazilian states of Minas Gerais and Espirito Santo using HPLC-DAD-MS/MS. Seventeen anthocyanins and other non-anthocyanic phenolic compounds were identified, with catechin and epicatechin being the main flavan-3-ols present in the fruits.
Article
Chemistry, Applied
Carolina Olivati, Yara P. O. Nishiyama, Roberto da Silva, Sergio Gomez-Alonso, Ellen S. Lago-Vanzela
Summary: The present study evaluated the effects of using EVOO as a pretreatment for the drying process of grapes on the phenolic compounds. The results showed that the EVOO treatment increased the content of phenolic compounds in raisins and reduced the drying time.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Entomology
Lorena Mazuecos, Marinela Contreras, Paul D. Kasaija, Prajwol Manandhar, Weronika Grazlewska, Eduardo Guisantes-Batan, Sergio Gomez-Alonso, Karelia Deulofeu, Isabel Fernandez-Moratalla, Rajesh Man Rajbhandari, Daniel Sojka, Libor Grubhoffer, Dibesh Karmacharya, Christian Gortazar, Jose de la Fuente
Summary: Ticks attaching to ear canals of humans and animals are the cause of otoacariasis, common in rural areas of Nepal. In indigenous medicine, leaf extracts of Clerodendrum viscosum are used as tick repellent to prevent or remove ticks from the ear canal. Our study provides support for the traditional use of C. viscosum leaf extracts in Nepal.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2023)
Article
Pharmacology & Pharmacy
Marta Rodriguez-Martinez, Maria Teresa Garcia, Jose Manuel Perez-Ortiz, Lucia Gonzalez, Sergio Gomez-Alonso, Irene Alvarez Lara, Ignacio Gracia, Juan Francisco Rodriguez, Javier Redondo-Calvo, Esther Garcia-Santos, David Padilla-Valverde
Summary: This study introduces the preclinical study of gemcitabine (GEM) impregnated in polymeric foams for intraoperative administration in pancreatic cancer (PC). The results show that the GEM-PLGA foam has good safety and drug release performance, and can be absorbed by the body.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carolina Olivati, Yara Paula Nishiyama-Hortense, Natalia Soares Janzantti, Roberto da Silva, Ellen Silva Lago Vanzela, Sergio Gomez-Alonso
Summary: Dark chocolate coated raisins treated with extra virgin olive oil showed increased concentrations of flavan-3-ols and proanthocyanidins compared to just raisins. The chocolate coating also led to the emergence of new compounds. This combination resulted in a dark chocolate coated raisin with good sensory acceptance and a more complex phenolic composition, potentially positively contributing to its functional quality.
Article
Food Science & Technology
Yara Paula Nishiyama-Hortense, Carolina Olivati, Jose Perez-Navarro, Reginaldo Teodoro Souza, Natalia S. Janzantti, Roberto Da-Silva, Isidro Hermosin-Gutierrez, Sergio Gomez-Alonso, Ellen Silva Lago-Vanzela
Summary: The study aimed to determine the phenolic compounds in the edible parts of BRS Carmem grapes harvested at two different stages of maturation. It was found that both mature and immature grapes contained high amounts of flavonols, anthocyanins, hydroxycinnamic acids derivatives, and stilbenes. The concentrations of these compounds were higher in the whole grapes compared to their skins, and higher in the seeds compared to the skins. Despite being immature, BRS Carmem grapes still exhibited a complex phenolic composition.
Article
Agriculture, Dairy & Animal Science
Rita Astudillo-Neira, Sandra Suescun-Ospina, Nelson Vera-Aguilera, Julio Alarcon-Enos, Jorge Avila-Stagno
Summary: The addition of white-rot fungi degraded hay improved in vitro digestibility and reduced methane production in the rumen. However, it had no significant effect on the concentration of total short-chain fatty acids.
ITALIAN JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Guisantes-Batan, Lorena Mazuecos, Blanca Rubio, Gema Pereira-Caro, Jose Manuel Moreno-Rojas, Antonio Andres, Sergio Gomez-Alonso, Nilda Gallardo
Summary: Regular consumption of grape seed extract (GSE) has beneficial effects on hepatic glucose and lipid metabolism. GSE activates AMPK and modulates the expression of ChREBP beta and PPAR beta/delta to improve liver function.
Article
Food Science & Technology
Yara Paula de Oliveira Nishiyama-Hortense, Maria Julia de Paula Rossi, Victoria Diniz Shimizu-Marin, Natalia Soares Janzantti, Sergio Gomez-Alonso, Roberto Da-Silva, Ellen Silva Lago-Vanzela
Summary: This study evaluated the applicability and quality of immature grape juice as a natural coloring ingredient in jelly candy. The composition of anthocyanins in the grapes, juice, and jelly candy were analyzed, and sensory analysis showed that the candy had a satisfactory taste and uniform color. The candy contained a considerable concentration of anthocyanins and had a grape odor and flavor.
Article
Plant Sciences
Michelly Cristiane Puludo, Silvia Borges Piamental de Olivira, Luciana Fontes de Oliveira, Ronam Carlos Colombo, Sergio Gomez-Alonso, Isidro Hermosin-Gutierrez, Rafaela Prata, Adriano Freitas Lima, Jose Teixeira Filho, Cristiano Augusto Ballus, Helena Teixeira Godoy
Summary: Jaboticaba, a plant extensively studied for its phenolic composition, was characterized in terms of anthocyanin and nonanthocyanin phenolic compositions in this study. The antiproliferative effect of five Jaboticaba varieties on breast and prostate cancer cells was also evaluated, with the Pintada variety from the 2015 crop showing the best action.
CURRENT PLANT BIOLOGY
(2022)