Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases

Characterization and expression analysis of genes encoding Taxol biosynthetic enzymes in Taxus spp.

(2021) Luyuan Jiang et al.   JOURNAL OF FORESTRY RESEARCH

Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees

(2021) Chunna Yu et al.   BMC PLANT BIOLOGY

Tissue‐specific study across the stem of Taxus media identifies a phloem‐specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis

(2020) Chunna Yu et al.   PLANT JOURNAL

The R2R3-MYB transcription factor family in Taxus chinensis: identification, characterization, expression profiling and posttranscriptional regulation analysis

(2020) Xinling Hu et al.   PeerJ

The Research Progress of taxol in Taxus

(2020) Fenjuan Shao et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Transcriptome analyses provide insights into the expression pattern and sequence similarity of several taxol biosynthesis-related genes in three Taxus species

(2019) Ting Zhou et al.   BMC PLANT BIOLOGY

Iso-Seq analysis of the Taxus cuspidata transcriptome reveals the complexity of Taxol biosynthesis

(2019) Xuejun Kuang et al.   BMC PLANT BIOLOGY

Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei

(2019) Tao Wang et al.   International Journal of Genomics

Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families

(2019) Hiroaki Kusano et al.   Frontiers in Plant Science

Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana

(2019) Jianhua Li et al.   Nature Communications

Activity Essential Residue Analysis of Taxoid 10β-O-Acetyl Transferase for Enzymatic Synthesis of Baccatin

(2018) Lin-Feng You et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Enhanced catalytic activities and modified substrate preferences for taxoid 10β-O-acetyl transferase mutants by engineering catalytic histidine residues

(2018) Lin-Feng You et al.   BIOTECHNOLOGY LETTERS

Transcriptome profiling reveals specific patterns of paclitaxel synthesis in a new Taxus yunnanensis cultivar

(2018) Chun-Tao He et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

TcMYC2a, a Basic Helix–Loop–Helix Transcription Factor, Transduces JA-Signals and Regulates Taxol Biosynthesis in Taxus chinensis

(2018) Meng Zhang et al.   Frontiers in Plant Science

Comparative metabolomics reveals the metabolic variations between two endangered Taxus species (T. fuana and T. yunnanensis) in the Himalayas

(2018) Chunna Yu et al.   BMC PLANT BIOLOGY

Comparative Transcriptome Analysis Revealed the Tissue-Specific Accumulations of Taxanes among Three Experimental Lines of Taxus yunnanensis

(2018) Samavia Mubeen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Comparative proteomic analyses of two Taxus species (Taxus � media and Taxus mairei) reveals variations in the metabolisms associated with paclitaxel and other metabolites

(2017) Juan Hao et al.   PLANT AND CELL PHYSIOLOGY

Identification of potential genes that contributed to the variation in the taxoid contents between two Taxus species (Taxus media and Taxus mairei)

(2017) Chunna Yu et al.   TREE PHYSIOLOGY

Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production

(2017) Bing-Juan Li et al.   Nature Communications

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

Transcript profiling of jasmonate-elicited Taxus cells reveals a β-phenylalanine-CoA ligase

(2015) Karla Ramírez-Estrada et al.   PLANT BIOTECHNOLOGY JOURNAL

Two jasmonate-responsive factors, TcERF12 and TcERF15, respectively act as repressor and activator of tasy gene of taxol biosynthesis in Taxus chinensis

(2015) Meng Zhang et al.   PLANT MOLECULAR BIOLOGY

Nature as a remarkable chemist

(2014) Mansukh C. Wani et al.   ANTI-CANCER DRUGS

Molecular cloning and characterization of a cytochrome P450 taxoid 9á-hydroxylase in Ginkgo biloba cells

(2014) Nan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids

(2014) Sarah Jarchow-Choy et al.   CURRENT ORGANIC CHEMISTRY

Paclitaxel: biosynthesis, production and future prospects

(2014) Susan Howat et al.   New Biotechnology

Will fungi be the new source of the blockbuster drug taxol?

(2014) S.K. Gond et al.   Fungal Biology Reviews

Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate

(2012) Shu-tao Li et al.   BMC GENOMICS

Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene inTaxus chinensis

(2012) S. Li et al.   PLANT BIOLOGY

The First Insight into the Tissue Specific Taxus Transcriptome via Illumina Second Generation Sequencing

(2011) Da Cheng Hao et al.   PLoS One

Overexpression of a 10-deacetylbaccatin III-10 β-O-acetyltransferase gene leads to increased taxol yield in cells of Taxus chinensis

(2010) Peng Zhang et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review

(2010) Sonia Malik et al.   PROCESS BIOCHEMISTRY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production

(2009) Daniela Hampel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Medicinal Chemistry of Paclitaxel and its Analogues

(2009) Y. Fu et al.   CURRENT MEDICINAL CHEMISTRY

AnN-Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificityin Vitrowith Analogues ofN-Dearoylpaclitaxel

(2009) Danielle M. Nevarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Origin and evolution of metabolic pathways

(2009) Renato Fani et al.   Physics of Life Reviews

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens

(2009) Aldwin Anterola et al.   TRANSGENIC RESEARCH

Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis

(2008) Robert M. Long et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS