Novel Semi-Synthetic Cu (II)–Cardamonin Complex Exerts Potent Anticancer Activity against Triple-Negative Breast and Pancreatic Cancer Cells via Inhibition of the Akt Signaling Pathway

Myc instructs and maintains pancreatic adenocarcinoma phenotype

(2020) Nicole M Sodir et al.   Cancer Discovery

Cytotoxic Activity of Boesenbergia rotunda Extracts against Nasopharyngeal Carcinoma Cells (HK1). Cardamonin, a Boesenbergia rotunda Constituent, Inhibits Growth and Migration of HK1 Cells by Inducing Caspase-Dependent Apoptosis and G2/M–Phase Arrest

(2020) Mohammed Khaled Bin Break et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cardamonin: A new player to fight cancer via multiple cancer signaling pathways

(2020) Javaria Nawaz et al.   LIFE SCIENCES

Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mTOR pathway

(2019) Xiaoshu Zhou et al.   ANTI-CANCER DRUGS

Cardiac glycoside Cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition

(2019) Md Shahadat Hossan et al.   CANCER LETTERS

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype

(2019) Corena V. Grant et al.   BREAST CANCER RESEARCH AND TREATMENT

Cardamonin induces G2/M arrest and apoptosis via activation of the JNK–FOXO3a pathway in breast cancer cells

(2019) Weiwei Kong et al.   CELL BIOLOGY INTERNATIONAL

New substituted quinoxalines inhibit triple-negative breast cancer by specifically downregulating the c-MYC transcription

(2019) Ming-Hao Hu et al.   NUCLEIC ACIDS RESEARCH

Epigallocatechin-3-Gallate (EGCG) Suppresses Pancreatic Cancer Cell Growth, Invasion, and Migration partly through the Inhibition of Akt Pathway and Epithelial–Mesenchymal Transition: Enhanced Efficacy when Combined with Gemcitabine

(2019) Wei et al.   Nutrients

Anti‑proliferative effect of cardamonin on mTOR inhibitor‑resistant cancer cells

(2019) Peiguang Niu et al.   Molecular Medicine Reports

Molecular docking and inhibitory effects of a novel cytotoxic agent with bovine liver catalase

(2019) Somaye Shahraki et al.   JOURNAL OF MOLECULAR STRUCTURE

Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review

(2018) Ricardo L. B. Costa et al.   BREAST CANCER RESEARCH AND TREATMENT

Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway

(2018) Mohammed Khaled Bin Break et al.   FITOTERAPIA

Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

(2018) Christopher J. Smedley et al.   Scientific Reports

Synthesis of coumaperine derivatives: Their NF-κB inhibitory effect, inhibition of cell migration and their cytotoxic activity

(2017) Natarajan Nandakumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways

(2017) Lingli Gong et al.   Cell Death & Disease

Cardamonin, a chalcone, inhibits human triple negative breast cancer cell invasiveness by downregulation of Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition

(2016) Shweta Shrivastava et al.   BIOFACTORS

In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B

(2016) Mohannad E. Qazzaz et al.   CANCER LETTERS

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage

(2016) Catarina Vizetto-Duarte et al.   PHYTOMEDICINE

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells

(2015) Ching-Fen Wu et al.   JOURNAL OF NATURAL PRODUCTS

Cardamonin Inhibits Angiogenesis by mTOR Downregulation in SKOV3 Cells

(2015) Zeng-Gui Xue et al.   PLANTA MEDICA

An Overview on Cardamonin

(2014) Luís Moreira Gonçalves et al.   JOURNAL OF MEDICINAL FOOD

mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion

(2014) Ying Tang et al.   LIFE SCIENCES

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

(2014) Kenbun Sone et al.   Nature Communications

Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

(2013) Hilary M Collins et al.   BMC CANCER

Anchorage-independent cell growth signature identifies tumors with metastatic potential

(2009) S Mori et al.   ONCOGENE