Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses

Adeno-Associated Virus Serotype-Specific Inverted Terminal Repeat Sequence Role in Vector Transgene Expression

(2020) Lauriel F. Earley et al.   HUMAN GENE THERAPY

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening

(2020) Kathleen Börner et al.   MOLECULAR THERAPY

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity

(2020) Julia Fakhiri et al.   JOURNAL OF VIROLOGY

AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo

(2020) Sara K. Powell et al.   MOLECULAR THERAPY

Establishment of a Recombinant AAV2/HBoV1 Vector Production System in Insect Cells

(2020) Xuefeng Deng et al.   Genes

Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy

(2020) James M. Wilson et al.   HUMAN GENE THERAPY

Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

(2020) Thilo Buck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of an In Vitro Biopotency Assay for an AAV8 Hemophilia B Gene Therapy Vector Suitable for Clinical Product Release

(2020) Johannes Lengler et al.   Molecular Therapy-Methods & Clinical Development

Production, Processing, and Characterization of synthetic AAV Gene Therapy Vectors

(2020) Jihad El Andari et al.   Biotechnology Journal

Novel chimeric gene therapy vectors based on Adeno-associated virus (AAV) and four different mammalian bocaviruses (BoV)

(2019) Julia Fakhiri et al.   Molecular Therapy-Methods & Clinical Development

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy of systemic temozolomide‐activated phage‐targeted gene therapy in human glioblastoma

(2019) Justyna Magdalena Przystal et al.   EMBO Molecular Medicine

Targeted AAVP-based therapy in a mouse model of human glioblastoma: a comparison of cytotoxic versus suicide gene delivery strategies

(2019) Fernanda I. Staquicini et al.   CANCER GENE THERAPY

Safe and sustained expression of human iduronidase after adeno-associated virus 9 intrathecal administration in infant rhesus monkeys

(2019) Juliette Hordeaux et al.   HUMAN GENE THERAPY

Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

(2019) Julia Tabatabai et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Immune System Stimulation by Oncolytic Rodent Protoparvoviruses

(2019) Assia Angelova et al.   Viruses-Basel

The hybrid AAVP tool gets an upgrade

(2019) João Alves-Cruzeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer

(2019) Keittisak Suwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanobody-enhanced targeting of AAV gene therapy vectors

(2019) Anna Marei Eichhoff et al.   Molecular Therapy-Methods & Clinical Development

A prokaryotic-eukaryotic hybrid viral vector for delivery of large cargos of genes and proteins into human cells

(2019) Jingen Zhu et al.   Science Advances

Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design

(2019) Pierce J. Ogden et al.   SCIENCE

Pathogenicity of a variant goose parvovirus, from short beak and dwarfism syndrome of Pekin ducks, in goose embryos and goslings

(2018) Kang Ning et al.   AVIAN PATHOLOGY

Severe Toxicity in Nonhuman Primates and Piglets Following High-Dose Intravenous Administration of an Adeno-Associated Virus Vector Expressing Human SMN

(2018) Christian Hinderer et al.   HUMAN GENE THERAPY

In Vivo Potency Assay for Adeno-Associated Virus–Based Gene Therapy Vectors Using AAVrh.10 as an Example

(2018) Bishnu P. De et al.   Human Gene Therapy Methods

Identification and characterization of a novel rodent bocavirus from different rodent species in China

(2018) Chi Zhang et al.   Emerging Microbes & Infections

Selective Inhibition of Histone Deacetylation in Melanoma Increases Targeted Gene Delivery by a Bacteriophage Viral Vector

(2018) Samuel Campbell et al.   Cancers

A Novel Molecular Design for a Hybrid Phage-DNA Construct Against DKK1

(2018) Saeed Khalili et al.   MOLECULAR BIOTECHNOLOGY

Establishment of a High Yield rAAV/HBoV Vector Production System Independent of Bocavirus Non-structural Proteins

(2018) Ziying Yan et al.   HUMAN GENE THERAPY

A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses

(2018) Anne-Kathrin Herrmann et al.   ACS Synthetic Biology

Association of the Human Bocavirus With Tonsil Squamous Cell Carcinomas

(2018) Merle Höpken et al.   Frontiers in Microbiology

Optimization of design and production strategies for novel adeno-associated viral display peptide libraries

(2017) J Körbelin et al.   GENE THERAPY

Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes

(2017) Ziying Yan et al.   HUMAN GENE THERAPY

Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution

(2017) Dirk Grimm et al.   HUMAN GENE THERAPY

Parvovirus Expresses a Small Noncoding RNA That Plays an Essential Role in Virus Replication

(2017) Zekun Wang et al.   JOURNAL OF VIROLOGY

Identification of liver-specific enhancer–promoter activity in the 3′ untranslated region of the wild-type AAV2 genome

(2017) Grant J Logan et al.   NATURE GENETICS

Genomic and pathogenic analysis of a Muscovy duck parvovirus strain causing short beak and dwarfism syndrome without tongue protrusion

(2017) Qiuling Fu et al.   RESEARCH IN VETERINARY SCIENCE

Next-generation AAV vectors for clinical use: an ever-accelerating race

(2017) Jonas Weinmann et al.   VIRUS GENES

Human Protoparvoviruses

(2017) Elina Väisänen et al.   Viruses-Basel

Evaluating Efficiencies of Dual AAV Approaches for Retinal Targeting

(2017) Livia S. Carvalho et al.   Frontiers in Neuroscience

Genetic and phylogenetic characterization of novel bocaparvovirus infecting chimpanzee

(2016) Kristýna Brožová et al.   INFECTION GENETICS AND EVOLUTION

Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China

(2016) Susanna K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Analysis ofcisandtransRequirements for DNA Replication at the Right-End Hairpin of the Human Bocavirus 1 Genome

(2016) Weiran Shen et al.   JOURNAL OF VIROLOGY

Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids

(2016) Fikret Aydemir et al.   JOURNAL OF VIROLOGY

Nonstructural Protein NP1 of Human Bocavirus 1 Plays a Critical Role in the Expression of Viral Capsid Proteins

(2016) Wei Zou et al.   JOURNAL OF VIROLOGY

Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries

(2016) Jakob Körbelin et al.   MOLECULAR THERAPY

Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

(2016) Joshua C Grieger et al.   MOLECULAR THERAPY

Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer

(2016) Fortunato Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes

(2016) Andrey S. Dobroff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas

(2016) Tracey L. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human bocavirus: Current knowledge and future challenges

(2016) Marcello Guido et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction

(2016) Effrosyni Tsafa et al.   Oncotarget

Expressing Transgenes That Exceed the Packaging Capacity of Adeno-Associated Virus Capsids

(2016) Kyle Chamberlain et al.   Human Gene Therapy Methods

Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways

(2016) Xuefeng Deng et al.   PLoS Pathogens

Manufacturing of recombinant adeno-associated viral vectors for clinical trials

(2016) Nathalie Clément et al.   Molecular Therapy-Methods & Clinical Development

Strategies to generate high-titer, high-potency recombinant AAV3 serotype vectors

(2016) Chen Ling et al.   Molecular Therapy-Methods & Clinical Development

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy

(2015) Randy J. Chandler et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Functional Analysis of Novel Nonstructural Proteins of Human Bocavirus 1

(2015) Weiran Shen et al.   JOURNAL OF VIROLOGY

Modulation of extracellular matrix in cancer is associated with enhanced tumor cell targeting by bacteriophage vectors

(2015) Teerapong Yata et al.   Molecular Cancer

E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal—Tailored Acceleration of AAV Evolution

(2015) Dirk Grimm et al.   MOLECULAR THERAPY

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

(2015) Jean-Charles Nault et al.   NATURE GENETICS

Role of capsid proteins in parvoviruses infection

(2015) Mengyu Tu et al.   Virology Journal

Engineering adeno-associated viruses for clinical gene therapy

(2014) Melissa A. Kotterman et al.   NATURE REVIEWS GENETICS

Porcine Bocavirus: Achievements in the Past Five Years

(2014) Feng Zhou et al.   Viruses-Basel

Hybrid Nanomaterial Complexes for Advanced Phage-guided Gene Delivery

(2014) Teerapong Yata et al.   Molecular Therapy-Nucleic Acids

The family Parvoviridae

(2013) Susan F. Cotmore et al.   ARCHIVES OF VIROLOGY

Triple Trans-Splicing Adeno-Associated Virus Vectors Capable of Transferring the Coding Sequence for Full-Length Dystrophin Protein into Dystrophic Mice

(2013) Taeyoung Koo et al.   HUMAN GENE THERAPY

Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis

(2013) Jeannine Lacroix et al.   INTERNATIONAL JOURNAL OF CANCER

Detection of HBoV DNA in idiopathic lung fibrosis, Cologne, Germany

(2013) Wolfram Windisch et al.   JOURNAL OF CLINICAL VIROLOGY

Structural Characterization of H-1 Parvovirus: Comparison of Infectious Virions to Empty Capsids

(2013) S. Halder et al.   JOURNAL OF VIROLOGY

Mechanistic Insights into the Enhancement of Adeno-Associated Virus Transduction by Proteasome Inhibitors

(2013) Angela M. Mitchell et al.   JOURNAL OF VIROLOGY

Adeno-Associated Virus Capsid Proteins May Play a Role in Transcription and Second-Strand Synthesis of Recombinant Genomes

(2013) M. Salganik et al.   JOURNAL OF VIROLOGY

A Novel Chimeric Adenoassociated Virus 2/Human Bocavirus 1 Parvovirus Vector Efficiently Transduces Human Airway Epithelia

(2013) Ziying Yan et al.   MOLECULAR THERAPY

In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine

(2013) P. Tao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Histone Deacetylation and DNA Methylation Improves Gene Expression Mediated by the Adeno-Associated Virus/Phage in Cancer Cells

(2013) Azadeh Kia et al.   Viruses-Basel

Parvovirus Diversity and DNA Damage Responses

(2013) S. F. Cotmore et al.   Cold Spring Harbor Perspectives in Biology

Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activity

(2012) Z Yuan et al.   CANCER GENE THERAPY

Antitumoral activity of parvovirus-mediated IL-2 and MCP-3/CCL7 delivery into human pancreatic cancer: implication of leucocyte recruitment

(2012) Sebastian Dempe et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Molecular Pathways: Rodent Parvoviruses--Mechanisms of Oncolysis and Prospects for Clinical Cancer Treatment

(2012) J. P. F. Nuesch et al.   CLINICAL CANCER RESEARCH

Clathrin-mediated Endocytosis and Subsequent Endo-Lysosomal Trafficking of Adeno-associated Virus/Phage

(2012) Charlotte A. Stoneham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication of Minute Virus of Mice in Murine Cells Is Facilitated by Virally Induced Depletion of p21

(2012) R. O. Adeyemi et al.   JOURNAL OF VIROLOGY

Dual Systemic Tumor Targeting with Ligand-Directed Phage and Grp78 Promoter Induces Tumor Regression

(2012) A. Kia et al.   MOLECULAR CANCER THERAPEUTICS

Proteasome inhibition in cancer is associated with enhanced tumor targeting by the adeno-associated virus/phage

(2012) Justyna M. Przystal et al.   Molecular Oncology

Establishment of a Reverse Genetics System for Studying Human Bocavirus in Human Airway Epithelia

(2012) Qinfeng Huang et al.   PLoS Pathogens

Interferon γ improves the vaccination potential of oncolytic parvovirus H-1PV for the treatment of peritoneal carcinomatosis in pancreatic cancer

(2011) Svitlana P. Grekova et al.   CANCER BIOLOGY & THERAPY

The Fecal Viral Flora of California Sea Lions

(2011) L. Li et al.   JOURNAL OF VIROLOGY

The parvoviral capsid controls an intracellular phase of infection essential for efficient killing of stepwise-transformed human fibroblasts

(2011) Justin Paglino et al.   VIROLOGY

Proteasome inhibition: A new therapeutic strategy to cancer treatment

(2010) William Ka Kei Wu et al.   CANCER LETTERS

Production, Purification and Characterization of Adeno-Associated Vectors

(2010) Eduard Ayuso et al.   CURRENT GENE THERAPY

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors

(2010) N Zeltner et al.   GENE THERAPY

Human Bocaviruses Are Highly Diverse, Dispersed, Recombination Prone, and Prevalent in Enteric Infections

(2010) Amit Kapoor et al.   JOURNAL OF INFECTIOUS DISEASES

Proteasome Inhibitors Enhance Gene Delivery by AAV Virus Vectors Expressing Large Genomes in Hemophilia Mouse and Dog Models: A Strategy for Broad Clinical Application

(2010) Paul E Monahan et al.   MOLECULAR THERAPY

Identification and Characterization of a New Bocavirus Species in Gorillas

(2010) Amit Kapoor et al.   PLoS One

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors

(2010) Gilles Moulay et al.   PLoS One

A viral assembly factor promotes AAV2 capsid formation in the nucleolus

(2010) F. Sonntag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parvovirus H-1 induces cytopathic effects in breast carcinoma-derived cultures

(2009) Ghaffar Muharram et al.   BREAST CANCER RESEARCH AND TREATMENT

Oncolytic Rat Parvovirus H-1PV, a Candidate for the Treatment of Human Lymphoma: In Vitro and In Vivo Studies

(2009) Assia L Angelova et al.   MOLECULAR THERAPY

Directed evolution of adeno-associated virus to an infectious respiratory virus

(2009) K. J. D. A. Excoffon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel Bocavirus Associated with Acute Gastroenteritis in Australian Children

(2009) Jane L. Arthur et al.   PLoS Pathogens

Tumor vasculature-targeted delivery of tumor necrosis factor-α*

(2008) Anita Tandle et al.   CANCER

Augmented transgene expression in transformed cells using a parvoviral hybrid vector

(2008) L Krüger et al.   CANCER GENE THERAPY

Enhancing transduction of the liver by adeno-associated viral vectors

(2008) A C Nathwani et al.   GENE THERAPY

Animal Bocaviruses: A Brief Review

(2008) Jill Manteufel et al.   INTERVIROLOGY

Molecular Characterization of the Heparin-Dependent Transduction Domain on the Capsid of a Novel Adeno-Associated Virus Isolate, AAV(VR-942)

(2008) M. Schmidt et al.   JOURNAL OF VIROLOGY

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY

Adeno-associated Virus of a Single-polarity DNA Genome Is Capable of Transduction In Vivo

(2008) Xiaohuai Zhou et al.   MOLECULAR THERAPY

DNA Shuffling of Adeno-associated Virus Yields Functionally Diverse Viral Progeny

(2008) James T Koerber et al.   MOLECULAR THERAPY

A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging

(2008) A. Hajitou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses

(2008) L. Zhong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA