Quantification of P-Glycoprotein in the Gastrointestinal Tract of Humans and Rodents: Methodology, Gut Region, Sex, and Species Matter

Sex- and Gender-Based Pharmacological Response to Drugs

(2021) Franck Mauvais-Jarvis et al.   PHARMACOLOGICAL REVIEWS

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

(2021) Zahari Vinarov et al.   ADVANCED DRUG DELIVERY REVIEWS

Impact of gastrointestinal physiology on drug absorption in special populations – An UNGAP review

(2020) Cordula Stillhart et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of Food and an Animal’s Sex on P-Glycoprotein Expression and Luminal Fluids in the Gastrointestinal Tract of Wistar Rats

(2020) Liu Dou et al.   Pharmaceutics

Robotic screening of intestinal drug absorption

(2020) Abdul W. Basit et al.   Nature Biomedical Engineering

Boosting drug bioavailability in men but not women through the action of an excipient

(2020) Yang Mai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Sex-Dependence in the Effect of Pharmaceutical Excipients: Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but not Female Rats

(2019) Mai et al.   Pharmaceutics

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

(2019) Bhagwat Prasad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review

(2019) Maria Vertzoni et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

An animal's sex influences the effects of the excipient PEG 400 on the intestinal P-gp protein and mRNA levels, which has implications for oral drug absorption

(2018) Yang Mai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Establishing an in vitro permeation model to predict the in vivo sex-related influence of PEG 400 on oral drug absorption

(2018) Yang Mai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes

(2018) Anna Vildhede et al.   MOLECULAR PHARMACEUTICS

P-glycoprotein expression in the gastrointestinal tract of male and female rats is influenced differently by food

(2018) Liu Dou et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens

(2018) Marek Drozdzik et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

An overview of technical considerations for Western blotting applications to physiological research

(2016) J. J. Bass et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans

(2015) Grace B. Hatton et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

(2015) Antonis Koussounadis et al.   Scientific Reports

Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine

(2014) Marek Drozdzik et al.   MOLECULAR PHARMACEUTICS

Simultaneous LC–MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma

(2014) Marija Bosilkovska et al.   Bioanalysis

In vitro and in vivo models for the study of oral delivery of nanoparticles

(2013) Jennifer M. Gamboa et al.   ADVANCED DRUG DELIVERY REVIEWS

LC–MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins

(2013) C. Gröer et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Human housekeeping genes, revisited

(2013) Eli Eisenberg et al.   TRENDS IN GENETICS

The Correlation Between the Expression of Differentiation Markers in Rat Small Intestinal Mucosa and the Transcript Levels of Schlafen 3

(2013) Pavlo L. Kovalenko et al.   JAMA Surgery

Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease

(2011) Alaa H. Abuznait et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Role of P-Glycoprotein in Region-Specific Gastrointestinal Absorption of Talinolol in Rats

(2010) L. Kagan et al.   DRUG METABOLISM AND DISPOSITION

Effect of Variations in the Amounts of P-Glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the Human Small Intestine on PBPK Models for Predicting Intestinal First Pass

(2010) Arnaud Bruyère et al.   MOLECULAR PHARMACEUTICS

A guide to Ussing chamber studies of mouse intestine

(2009) Lane L. Clarke   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes

(2008) Yanfang Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues

(2008) Michael D George et al.   BMC GENOMICS

Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats

(2008) C. MacLean et al.   DRUG METABOLISM AND DISPOSITION

Segmental Dependent Transport of Low Permeability Compounds along the Small Intestine Due to P-Glycoprotein: The Role of Efflux Transport in the Oral Absorption of BCS Class III Drugs

(2008) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

Polyethylene Glycol 400 Enhances the Bioavailability of a BCS Class III Drug (Ranitidine) in Male Subjects but Not Females

(2008) Diane A. I. Ashiru et al.   PHARMACEUTICAL RESEARCH