Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Rhafaela Lima Causin, Andre Van Helvoort Lengert, Izabela Natalia Faria Gomes, Ana Julia Aguiar De Freitas, Marcela Nunes Rosa, Ricardo Dos Reis, Rui Manuel Reis, Marcia Maria Chiquitelli Marques
Summary: miR-130a-3p is overexpressed in cervical cancer cells and plays a significant role in the development of cervical cancer. Inhibiting miR-130a-3p can significantly reduce the proliferation, migration, and invasion of cervical cancer cells. miR-130a-3p may regulate the biological functions of cervical cancer cells by directly targeting the DLL1 gene. Therefore, miR-130a-3p may serve as a biomarker for determining cervical cancer progression.
Article
Medicine, General & Internal
Cecil J. Weale, Don M. Matshazi, Saarah F. G. Davids, Shanel Raghubeer, Rajiv T. Erasmus, Andre P. Kengne, Glenda M. Davison, Tandi E. Matsha
Summary: This study found that miR-1299, miR-126-3p, and miR-30e-3p are associated with prediabetes, with miR-126-3p showing higher diagnostic capability for prediabetes.
Review
Oncology
Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar, Mohammad Taheri
Summary: miRNAs play a significant role in breast carcinogenesis by modulating key processes and potentially affecting treatment outcomes. Their presence in the peripheral blood of patients also offers a new avenue for non-invasive diagnosis of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jiaxin Luo, Lingxi Jiang, Changyu He, Minmin Shi, Zhong-Yin Yang, Min Shi, Sheng Lu, Chen Li, Jun Zhang, Min Yan, Zheng-Gang Zhu, Chao Yan
Summary: This study found that the expression levels of microRNAs in peritoneal lavage samples of gastric cancer patients are associated with peritoneal metastasis. Specifically, hsa-let-7g-3p and hsa-miR-10395-3p have been identified as biomarkers predicting peritoneal metastasis and the efficacy of intraperitoneal chemotherapy.
Article
Biochemistry & Molecular Biology
Fatima Domenica Elisa De Palma, Francesco Salvatore, Jonathan G. Pol, Guido Kroemer, Maria Chiara Maiuri
Summary: The management of breast cancer relies on imaging, immunohistochemical and molecular evaluations. Circular RNAs (circRNAs) play a key role in breast cancer development and progression. They have potential as non-invasive biomarkers for diagnosis, prognosis and prediction in breast cancer.
Article
Biotechnology & Applied Microbiology
Zahra Nashtahosseini, Mahmoud Reza Aghamaali, Farzin Sadeghi, Nadia Heydari, Hadi Parsian
Summary: The study investigated the expression levels of serum miR-660-5p and miR-210-3p in breast cancer patients compared to healthy controls. The results showed significant up-regulation of these microRNAs in breast cancer patients, especially in the early stages, indicating their potential as biomarkers for breast cancer detection with reasonable sensitivity and specificity. Further large-scale studies are needed to confirm these preliminary findings.
JOURNAL OF GENE MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Iris Garrido-Cano, Anna Adam-Artigues, Ana Lameirinhas, Juan F. F. Blandez, Vicente Candela-Noguera, Ana Lluch, Begona Bermejo, Felix Sancenon, Juan Miguel Cejalvo, Ramoin Martinez-Manez, Pilar Eroles
Summary: Despite advances in breast cancer treatment, it remains the leading cause of cancer-related death in women worldwide. In this study, a nanodevice using mesoporous silica nanoparticles for miR-200c-3p delivery was designed and validated. The nanodevice demonstrated biocompatibility, escape ability from endosomes/lysosomes, and inhibition of tumor progression, invasion, migration, and proliferation in vitro. In vivo experiments confirmed tumor targeting, effective miR-200c-3p delivery, therapeutic efficacy with reduced tumor size and lung metastasis, and no signs of toxicity. Overall, miR-200c-3p-loaded nanoparticles present a potential strategy for breast cancer therapy and safe tumor-targeted delivery of microRNAs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Oncology
Chun-Wen Cheng, Wen-Ling Liao, Po-Ming Chen, Jyh-Cherng Yu, Hui-Ping Shiau, Yi-Hsien Hsieh, Huei-Jane Lee, Yu-Chun Cheng, Pei-Ei Wu, Chen-Yang Shen
Summary: The study demonstrates that miR-139 can suppress invasion and migration of breast cancer stem cells by down-regulating CXCR4/p-Akt signaling, and its reduced expression is associated with worse clinicopathological features in breast cancer patients, suggesting it as a potential therapeutic target for invasive breast cancer.
Article
Medicine, General & Internal
Soo Jung Lee, Jae-Hwan Jeong, Jeeyeon Lee, Ho Yong Park, Jin Hyang Jung, Jieun Kang, Eun Ae Kim, Nora Jee-Young Park, Ji-Young Park, In Hee Lee, Yee Soo Chae
Summary: The study indicates that miR-496 and miR-137 may modulate the progression of triple negative breast cancer (TNBC) by targeting the Del-1 gene, potentially serving as new biomarkers for patients with TNBC.
Article
Public, Environmental & Occupational Health
Qiang Li, Yao Liu, Jiajia Bai, Song Zhao, Yawen Wang, Arzoo Shabbir, Kai Zhang, Fan Jiang, Jiang Zhu, Rong Ma, Jianli Wang
Summary: The study identified miR-140-3p as a significantly downregulated miRNA in BPT, serving as a potential differential biomarker.
Six differentially expressed miRNAs between BPT and FA were identified using miRNA-Seq technique, including two downregulated genes and four upregulated genes.
Validation by qRT-PCR showed that miR-140-3p was downregulated by approximately 70% in BPT.
Article
Biochemistry & Molecular Biology
Monique de Fatima Mello Santana, Maria Isabela Bloise Alves Caldas Sawada, Aritania Sousa Santos, Mozania Reis, Jacira Xavier, Maria Lucia Correa-Giannella, Andrea Harumy de Lima Hirata, Luiz Henrique Gebrim, Francisco Garcia Soriano, Cleber Pinto Camacho, Marisa Passarelli
Summary: The study examined the expression of inflammation-related miRs bound to HDLs in breast cancer patients and controls. It was found that HDL from breast cancer patients had higher anti-inflammatory activity compared to controls, especially in advanced stages of the disease. The miRs 223-3p and 375-3p in HDLs were significantly higher in breast cancer patients and showed high discriminatory power between breast cancer and controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Physiology
Jian Han, Xiaogang Cui, Tianqi Yuan, Zhiming Yang, Yue Liu, Yajuan Ren, Changxin Wu, Yunfei Bian
Summary: Circulating exosomal miRNAs have potential as biomarkers for diagnosis of cardiovascular diseases. In this study, the differentially expressed miRNAs in exosomes from plasma of SCAD patients were analyzed and their diagnostic potential for SCAD was investigated.
FRONTIERS IN PHYSIOLOGY
(2023)