Journal
MOLECULAR IMMUNOLOGY
Volume 133, Issue -, Pages 110-121Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2021.02.015
Keywords
Hepcidin; Insulin resistance; Inflammation; Macrophage extracellular traps
Categories
Funding
- National Natural Science Foundation of China [81873534, 81670411, 81570400, 81400285]
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The study showed that inflammation and insulin resistance significantly improved in obese mice, and inhibition of METs formation and attenuation of the inflammatory response were observed through hepcidin gene silencing. Therefore, hepcidin gene silencing may play a crucial role in treating diabetes by ameliorating inflammation.
As a major feature of diabetes, inflammation is closely related to macrophage extracellular traps and the expression of hepcidin upregulated by diabetes is reportedly involved in chronic inflammation. Therefore, we aimed to explore whether hepcidin could be implicated in inflammation and macrophage extracellular traps (METs) formation. The diabetic db/db mouse model was established exhibiting insulin resistance (IR), inflammation, macrophages infiltration and higher expression of hepcidin, where samples were obtained from epididymal adipose tissue. We observed that inflammation and IR improved in adipose tissue of mice treated with hepcidin gene silencing. Furthermore, METs formation could be markedly inhibited via hepcidin gene silencing followed by attenuated inflammatory response due to METs, indicating hepcidin gene silencing played a key role in anti-inflammation by inhibiting METs formation. So, we concluded that hepcidin gene silencing has a potential for treatment of diabetes due to its ability to ameliorate inflammation via inhibiting METs formation.
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