In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase

A novel coronavirus outbreak of global health concern

(2020) Chen Wang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

(2020) Guangdi Li et al.   NATURE REVIEWS DRUG DISCOVERY

Clinical Characteristics of Coronavirus Disease 2019 in China

(2020) Wei-jie Guan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

(2020) Jasper Fuk-Woo Chan et al.   Emerging Microbes & Infections

Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing

(2020) Bei Li et al.   mSphere

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China

(2020) Zhongliang Wang et al.   CLINICAL INFECTIOUS DISEASES

Favipiravir: Pharmacokinetics and Concerns About Clinical Trials for 2019‐nCoV Infection

(2020) Yin‐Xiao Du et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspective

(2020) Abdo A. Elfiky   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The convalescent sera option for containing COVID-19

(2020) Arturo Casadevall et al.   JOURNAL OF CLINICAL INVESTIGATION

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir: Review of pharmacology, pre‐clinical data and emerging clinical experience for COVID‐19

(2020) Sarah CJ Jorgensen et al.   PHARMACOTHERAPY

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

(2020) Wanchao Yin et al.   SCIENCE

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

Chemistry and Biology of SARS-CoV-2

(2020) Alexander Dömling et al.   Chem

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

(2020) Maria Romano et al.   Cells

A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions

(2020) Sabari Nath Neerukonda et al.   Pathogens

Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2

(2020) Deepak S. Chauhan et al.   BIOCONJUGATE CHEMISTRY

COVID19 inhibitors: A prospective therapeutics

(2020) Md Jawaid Akhtar   BIOORGANIC CHEMISTRY

Remdesivir (GS-5734) as a therapeutic option of 2019-nCOV main protease – in silico approach

(2020) Vankudavath Raju Naik et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Natural compounds from Clerodendrum spp. as possible therapeutic candidates against SARS-CoV-2: An in silico investigation

(2020) Pallab Kar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target

(2020) Yanyan Wang et al.   JOURNAL OF MEDICAL VIROLOGY

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19

(2020) Minchen Chien et al.   JOURNAL OF PROTEOME RESEARCH

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study

(2020) Abdo A. Elfiky   LIFE SCIENCES

Current Status of Multiple Drug Molecules, and Vaccines: An Update in SARS-CoV-2 Therapeutics

(2020) Ramesh Kandimalla et al.   MOLECULAR NEUROBIOLOGY

Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID‐19) and the rationale for their utilization: A review

(2020) Richard A. Giovane et al.   REVIEWS IN MEDICAL VIROLOGY

Repurposing Therapeutics for Potential Treatment of SARS-CoV-2: A Review

(2020) Jennifer Santos et al.   Viruses-Basel

Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics

(2020) Mubarak A. Alamri et al.   Arabian Journal of Chemistry

A Review on Remdesivir: A Possible Promising Agent for the Treatment of COVID-19

(2020) Seyed MohammadReza Hashemian et al.   Drug Design Development and Therapy

High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment

(2020) Biswajit Naik et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses

(2020) Anna Artese et al.   DRUG RESISTANCE UPDATES

In silico design of small peptides antagonist against leptin receptor for the treatment of obesity and its associated immune-mediated diseases

(2018) Manne Munikumar et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Prodrug approach: An overview of recent cases

(2017) Valentina Abet et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase

(2013) Hidehiro Sangawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-based approaches to develop epitope-driven subunit vaccines against pathogens of infective endocarditis

(2013) Vani Priyadarshini et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Para-(benzoyl)-phenylalanine as a potential inhibitor against LpxC ofLeptospiraspp.: homology modeling, docking, and molecular dynamics study

(2013) Dibyabhaba Pradhan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

An overview of the Amber biomolecular simulation package

(2012) Romelia Salomon-Ferrer et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Oseltamivir Carboxylate, the Active Metabolite of Oseltamivir Phosphate (Tamiflu), Detected in Sewage Discharge and River Water in Japan

(2009) Gopal C. Ghosh et al.   ENVIRONMENTAL HEALTH PERSPECTIVES