Journal
MOLECULAR CELL
Volume 81, Issue 7, Pages 1370-1371Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2021.03.005
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The study identified NINJ1 as a mediator of plasma membrane rupture following programmed cell death, challenging the previous notion that this event was passive.
Using a forward-genetic screening of macrophages from randomly mutagenized mice, Kayagaki et al. (2021) identify NINJ1 that mediates plasma membrane rupture following various types of programmed cell death, an event previously thought to be passive.
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