Blocking TLR4-NF-κB pathway protects mouse islets from the combinatorial impact of high fat and fetuin-A mediated dysfunction and restores ability for insulin secretion

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

(2020) Ji-Hyeon Lee et al.   Cell Death & Disease

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

(2019) Yewei Ji et al.   NATURE IMMUNOLOGY

TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway

(2019) Xide Chen et al.   Journal of Diabetes Research

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice

(2016) Ting Zhang et al.   ENDOCRINOLOGY

An optimized protocol for purification of functional islets of Langerhans

(2016) Youakim Saliba et al.   LABORATORY INVESTIGATION

CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways

(2016) Chaoqun Wang et al.   Oncotarget

Fetuin A promotes lipotoxicity in β cells through the TLR4 signaling pathway and the role of pioglitazone in anti-lipotoxicity

(2015) Ximei Shen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TLR4/NF-κB Signaling Contributes to Chronic Unpredictable Mild Stress-Induced Atherosclerosis in ApoE-/- Mice

(2015) Ya Ling Tang et al.   PLoS One

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells

(2014) Dorothea I. Siegel-Axel et al.   DIABETOLOGIA

TLR4 is required for the obesity-induced pancreatic beta cell dysfunction

(2013) J. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

Adipocyte Fetuin-A Contributes to Macrophage Migration into Adipose Tissue and Polarization of Macrophages

(2013) Priyajit Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Nuclear Factor-κB Activation in Pancreatic β-Cells Has a Protective Effect on Allogeneic Pancreatic Islet Graft Survival

(2013) Roy Eldor et al.   PLoS One

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

(2013) Nicolas Pierre et al.   PLoS One

Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications

(2013) Norbert Stefan et al.   Lancet Diabetes & Endocrinology

Beta Cell Dysfunction and Insulin Resistance

(2013) Marlon E. Cerf   Frontiers in Endocrinology

The Inflammasome Puts Obesity in the Danger Zone

(2012) Rinke Stienstra et al.   Cell Metabolism

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

(2012) Kosei Eguchi et al.   Cell Metabolism

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Conditional β1-integrin-deficient mice display impaired pancreatic β cell function

(2011) M. Riopel et al.   JOURNAL OF PATHOLOGY

Consistency of the Disposition Index in the Face of Diet Induced Insulin Resistance: Potential Role of FFA

(2011) Darko Stefanovski et al.   PLoS One

NF-κB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance

(2010) Suman Dasgupta et al.   BIOCHEMICAL JOURNAL

Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients

(2010) Patty W. Siri-Tarino et al.   Current Atherosclerosis Reports

FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages

(2010) WuQiang Fan et al.   EMBO JOURNAL

Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis

(2010) Meredith J. H. Hutton et al.   Islets

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest

(2008) Z. X. Meng et al.   DIABETOLOGIA

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS