Design and development of novel inhibitors of aldo-ketoreductase 1C1 as potential lead molecules in treatment of breast cancer

QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery

(2018) Bruno J. Neves et al.   Frontiers in Pharmacology

In vitro inhibition of AKR1Cs by sulphonylureas and the structural basis

(2015) Yining Zhao et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Breast Cancer After Use of Estrogen Plus Progestin and Estrogen Alone

(2015) Rowan T. Chlebowski et al.   JAMA Oncology

Epidemiological Correlates of Breast Cancer in South India

(2014) Giridhara Rathnaiah Babu et al.   Asian Pacific Journal of Cancer Prevention

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

(2014) Kiyoshi Okamoto et al.   ACS Medicinal Chemistry Letters

Risk factors of female breast carcinoma: A case control study at Puducherry

(2013) SM Balasubramaniam et al.   INDIAN JOURNAL OF CANCER

Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism

(2013) Tea Lanišnik Rižner et al.   STEROIDS

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer

(2012) Mo Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Progesterone Receptor-A and -B Have Opposite Effects on Proinflammatory Gene Expression in Human Myometrial Cells: Implications for Progesterone Actions in Human Pregnancy and Parturition

(2012) Huiqing Tan et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

(2012) Petra Brožič et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3

(2012) Stephen M. F. Jamieson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships

(2012) Adegoke O. Adeniji et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore modeling, virtual screening and docking studies to identify novel HNMT inhibitors

(2012) Pavadai Elumalai et al.   Journal of the Taiwan Institute of Chemical Engineers

Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis

(2011) Ossama El-Kabbani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combined ligand based pharmacophore modeling, virtual screening methods to identify critical chemical features of novel potential inhibitors for phosphodiesterase-5

(2011) Meganathan Chandrasekaran et al.   Journal of the Taiwan Institute of Chemical Engineers

3D QSAR pharmacophore based virtual screening and molecular docking for identification of potential HSP90 inhibitors

(2010) Sugunadevi Sakkiah et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1)

(2010) Ossama El-Kabbani et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

FDA Approval Summary: Temsirolimus as Treatment for Advanced Renal Cell Carcinoma

(2010) V. E. Kwitkowski et al.   ONCOLOGIST

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3

(2009) Bogdan Štefane et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-Guided Design, Synthesis, and Evaluation of Salicylic Acid-Based Inhibitors Targeting a Selectivity Pocket in the Active Site of Human 20α-Hydroxysteroid Dehydrogenase (AKR1C1)

(2009) Ossama El-Kabbani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Minireview: Fetal-Maternal Hormonal Signaling in Pregnancy and Labor

(2009) Carole R. Mendelson   MOLECULAR ENDOCRINOLOGY

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20α-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity

(2008) Vincenzo Carbone et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Selectivity Determinants of Inhibitor Binding to Human 20α-Hydroxysteroid Dehydrogenase: Crystal Structure of the Enzyme in Ternary Complex with Coenzyme and the Potent Inhibitor 3,5-Dichlorosalicylic Acid†

(2008) Urmi Dhagat et al.   JOURNAL OF MEDICINAL CHEMISTRY