Hypoglycemia in mitochondrial disorders

Diabetes and hyperglycemia are common features of mitochondrial disorders. This study investigates the frequency of non-iatrogenic hypoglycemia in individuals with these disorders. Of 116 patients, 22 (18.97%) experienced at least two episodes of hypoglycemia. This rate is significantly higher (p < 0.05) than the 6% seen in the non-diabetic, general population. Neonatal readings were 30 mg/dL lower than non-neonatal readings. As hypoglycemia appears to occur frequently in individuals with mitochondrial disorders, with lower blood glucose levels in the neonatal period, early and continued monitoring of blood glucose is necessary. Also, mitochondrial disorders should be considered in cases of recurrent hypoglycemia.

Automated summary

This study found a high frequency of non-iatrogenic hypoglycemia in individuals with mitochondrial disorders, especially in neonates. Early and continuous monitoring of blood glucose levels is necessary, as well as considering mitochondrial disorders in cases of recurrent hypoglycemia.