Article
Immunology
Bing Wang, Heqiong Li, Zhen Li, Bo Wang, Han Zhang, Boyan Zhang, Hailing Luo
Summary: The beneficial effects of folic acid on lamb growth performance and immunity were observed, and the molecular mechanisms of folic acid in lambs were analyzed. The study found that folic acid was influenced by maternal and offspring diet, and it altered metabolites, genes, and pathways in blood, liver, and muscle. These findings provide a theoretical basis for the use of folic acid in animal health care.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Zhipeng Liu, Yuntao Zhang, Zengjiao Liu, Zhen Tian, Xinyi Pei, Liyan Liu, Ying Li
Summary: Folic acid oversupplementation during pregnancy can lead to lipid metabolism disorder in male offspring, possibly by regulating the Arg1-NOS3-AMPKa pathway and causing lipid accumulation in hepatocytes.
CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Bo Chen, Yongjun Wang, Qing Wang, Dingqi Li, Xiaotan Huang, Xiaojin Kuang, Shuzhong Wang, Zhaotun Hu
Summary: Crohn's disease is characterized by chronic inflammation of the gastrointestinal tract. This study used untargeted metabolomics analysis to identify potential biomarkers for CD diagnosis. Lipid metabolism was found to be significantly associated with CD pathogenesis, and specific metabolites such as ceramide, phosphatidylethanolamine, and taurochenodeoxycholic acid showed high predictive accuracy for CD patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sofia Milosavljevic, Kevin E. Glinton, Xiqi Li, Claudia Medeiros, Patrick Gillespie, John R. Seavitt, Brett H. Graham, Sarah H. Elsea
Summary: Deficiency of SLC13A5 causes a broader state of metabolic dysregulation than previously recognized, particularly regarding lipid synthesis, storage, and metabolism.
Article
Physiology
Jun Wang, Wen-Yu Yang, Xiao-Han Li, Bei Xu, Yu-Wei Yang, Bin Zhang, Chun-Mei Dai, Jia-Fu Feng
Summary: This study analyzed the serum metabolite profile of patients with renal cell carcinoma (RCC) and identified potential diagnostic biomarkers. The findings suggest that changes in glycerophospholipid metabolism, phosphatidylinositol signaling system, glycerolipid metabolism, d-glutamine and d-glutamate metabolism, galactose metabolism, and folate biosynthesis may be involved in the occurrence of RCC. Furthermore, the metabolites 3-beta-D-Galactosyl-sn-glycerol, 7,8-Dihydroneopterin, lysophosphatidylcholine (LPC) 19:2, and gamma-Aminobutyryl-lysine were found to have high clinical value in the diagnosis and differential diagnosis of RCC.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Ping-Yuan Ge, Yi-Yu Qi, Shu-Yue Qu, Xin Zhao, Sai-jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Qi-Chun Zhang, Hua-Xu Zhu
Summary: S. baicalensis modulates lipid metabolism through pathways such as steroid biosynthesis, sphingolipid metabolism, the PPAR signaling pathway, and glycerolipid metabolism. Metabolomics studies indicate that cholesterol metabolism and sphingolipid metabolism are the most relevant pathways associated with the effects of S. baicalensis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Lin Yu, Qinhuai Lai, Qian Feng, Yuanmeng Li, Jiafu Feng, Bei Xu
Summary: This study revealed that lipid metabolism may play a crucial role in the progression from chronic gastritis to gastric cancer. Hexadecasphinganine, linoleamide, and N-Hydroxy arachidonoyl amine were identified as candidate diagnostic markers for chronic gastritis and gastric cancer. Additionally, changes in serum lipid levels, including total cholesterol, high-density lipoprotein cholesterol, and apolipoprotein A1, were observed with disease progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hao- Xiong, Hui-Tao Zhang, Hong-Wen Xiao, Chun-Lan Huang, Mei-Zhou Huang
Summary: The study found that metabolomic analysis can better differentiate different types and states of leukemia based on existing clinical diagnostic techniques. The metabolism of choline and betaine may be significantly related to the patient's blood lipid profile. The main enrichment pathways for distinguishing differential metabolites are amino acid metabolism and fatty acid metabolism.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Xuexuan Ding, Jingtong Qin, Fangfang Huang, Fuhai Feng, Lianxiang Luo
Summary: This study explores the biomarkers and molecular mechanisms associated with lipid metabolism in asthma using high-throughput data analysis methods. The CH25H gene is identified as a core player in asthma and, together with other lipid metabolism genes, forms a lipid metabolism gene set that effectively distinguishes different subtypes. The results of non-targeted metabolomics indicate the presence of multiple differentially expressed lipid metabolites in the plasma of asthmatic mice. Thus, the CH25H gene may serve as a useful biomarker for the diagnosis of asthma.
INFLAMMATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yulai Fang, Cong Duan, Jing Zhang, Yue Dai, Yufeng Xia
Summary: Norisoboldine (NOR) alleviated collagen-induced arthritis by modulating lipid metabolism and other pathways, showing a strong association between rheumatoid arthritis and metabolic disorders. The differential metabolites and related pathways may serve as novel therapeutic targets for RA treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Fouad Choueiry, Rui Xu, Jiangjiang Zhu
Summary: Staphylococcus aureus, an opportunistic pathogen, relies on host-derived environmental signals and metabolic adaptation to cause infections. In this study, we investigated the effects of environmental factors on SA metabolism and its correlation with the expression of virulence genes. Our findings provide insights into the adaptive growth and virulence of SA, and may facilitate the development of metabolic inhibitors/modulators to mitigate SA infections.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Environmental Sciences
Haotian Wu, Vrinda Kalia, Megan M. Niedzwiecki, Marianthi-Anna Kioumourtzoglou, Brandon Pierce, Vesna Ilievski, Jeff Goldsmith, Dean P. Jones, Ana Navas-Acien, Douglas I. Walker, Mary Gamble
Summary: Chronic exposure to arsenic remains a global health concern, but the biological mechanisms underlying its adverse effects are not fully understood. This study used metabolomics to examine how arsenic affects metabolic pathways in humans. The results identified multiple metabolites and pathways associated with arsenic exposure.
Article
Immunology
Yongshuo Yin, Lina Cao, Meng Zhang, Yingjie Li, Chunhua Sun, Qinghua Ma, Zhaoyun Liu, Chao Li, Zhiyong Yu, Xiao Guan
Summary: This study applied label-free quantitative proteomics and non-targeted metabonomics to identify potential biomarkers for diagnosing CA-MRSA infection in breast abscess. The results showed differential expression of proteins and metabolites in CA-MRSA infection compared to MSSA. The identified biomarkers displayed good discriminative abilities in early identification of CA-MRSA infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Henna Myllymaki, Jeanette Astorga Johansson, Estefania Grados Porro, Abigail Elliot, Tessa Moses, Yi Feng
Summary: Metabolic rewiring is crucial for tumorigenesis, and this study identified six significantly altered metabolic pathways during pre-neoplastic cell development induced by HRAS(G12V) using a zebrafish model. These pathways include pyrimidine, purine, and amino acid metabolism, which are common in cancer metabolic changes supporting rapid cell proliferation and growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Mahesh S. Krishna, V. M. Revathy, Abdul Jaleel
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Gopika Satheesh, Surya Ramachandran, Abdul Jaleel
METABOLIC SYNDROME AND RELATED DISORDERS
(2020)
Article
Cell Biology
Vikas Kumar, A. Aneesh Kumar, Vinod Joseph, Vipin Mohan Dan, Abdul Jaleel, T. R. Santhosh Kumar, Chandrasekharan C. Kartha
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Multidisciplinary Sciences
A. Aneesh Kumar, Gopika Satheesh, Gadadharan Vijayakumar, Mahesh Chandran, Priya R. Prabhu, Leena Simon, Vellappillil Raman Kutty, Chandrasekharan C. Kartha, Abdul Jaleel
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
A. Aneesh Kumar, Gopika Satheesh, Gadadharan Vijayakumar, Mahesh Chandran, Priya R. Prabhu, Leena Simon, Vellappillil Raman Kutty, Chandrasekharan C. Kartha, Abdul Jaleel
Review
Pharmacology & Pharmacy
Vasantha Kalaivani, Abdul Jaleel
PHARMACOLOGICAL RESEARCH
(2020)
Article
Biochemical Research Methods
Vaijayanti A. Tamhane, Surhud S. Sant, Abhilash R. Jadhav, Abdul R. War, Hari C. Sharma, Abdul Jaleel, Akanksha S. Kashikar
Summary: The study analyzed the proteomes of three sorghum genotypes with different resistance levels to insect pests, identifying potential leaf proteins contributing to resistance. Sorghum responded to spotted stem borer infestation by suppressing protein and amino acid biosynthesis, and inducing proteins involved in photosynthesis and stress response. Resistant sorghum genotypes showed a higher number of unique proteins compared to susceptible genotypes, mainly involved in catalytic activities.
Article
Pharmacology & Pharmacy
Abdul Riyas, Aneesh Kumar, Mahesh Chandran, Abdul Jaleel, Appukuttannair Biju Kumar
Summary: The study characterized the proteome of jellyfish venom from three bloom-forming scyphozoan jellyfish along the south-west coast of India, identifying various toxins and unique proteins. Different types of chemical defence armoury were found in the venom of these jellyfish, with Cyanea nozakii containing a protective antioxidant enzyme in abundance. Proteomic data from this study has been made publicly available.
Article
Genetics & Heredity
A. Aneesh Kumar, G. S. Ajith Kumar, Gopika Satheesh, Arun Surendran, Mahesh Chandran, Chandrasekharan C. Kartha, Abdul Jaleel
Summary: Proteomic analysis revealed differential protein expression and pathway enrichment in aortic-valvular and endocardial endothelial cells, suggesting distinct phenotypes and signaling pathways in these closely related cells. Hemostasis function-related proteins were increased in both endothelial cells, while metabolic process-related proteins and extracellular matrix-related proteins were enriched in valves.
Article
Cell Biology
Vinitha Anandan, Thushara Thulaseedharan, Aishwarya Suresh Kumar, Karthika Chandran Latha, Amjesh Revikumar, Ajit Mullasari, Chandrasekharan C. Kartha, Abdul Jaleel, Surya Ramachandran
Summary: The impairment of efferocytosis in apoptotic macrophages by cyclophilin A is linked to reduced cholesterol efflux and altered expression of CD 47 and calreticulin. These effects can exacerbate other mechanisms of Cyp A in accelerating atherosclerosis progression, as shown in New Zealand white rabbits on a high-fat diet. Further studies are needed to explore the precise mechanisms involved in impaired efferocytosis and the potential therapeutic targets for atherosclerosis.
Article
Biochemistry & Molecular Biology
C. A. Jabeena, Gayathri Govindaraju, Mukul Rawat, Soundhararajan Gopi, Devadathan Valiyamangalath Sethumadhavan, Abdul Jaleel, Dhakshmi Sasankan, Krishanpal Karmodiya, Arumugam Rajavelu
Summary: This study identified a novel histone modification, H3K64me3, in Plasmodium falciparum, showing dynamic changes throughout different stages of the parasite's life cycle. The researchers also found that this modification is selectively enriched on genes encoding exported proteins, indicating a potential role in regulating their expression in different stages.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Vinitha Anandan, Santhosh Kumar Thankayyan Retnabai, Abdul Jaleel, Thushara Thulaseedharan, Ajit Mullasari, M. Radhakrishna Pillai, Cheranellore Chandrasekharan Kartha, Surya Ramachandran
Summary: The study reveals the mechanism by which cyclophilin A induces macrophage apoptosis and accelerates the progression of atherosclerosis. Inhibitors of proinflammatory cytokines like cyclophilin A may prevent macrophage apoptosis and lead to regression of advanced atherosclerotic lesions.
Article
Cardiac & Cardiovascular Systems
Arun Surendran, Andrea Edel, Mahesh Chandran, Pascal Bogaert, Pedram Hassan-Tash, Aneesh Kumar Asokan, Brett Hiebert, Zahra Solati, Shubhkarman Sandhawalia, Michael Raabe, Malek Kass, Ashish Shah, Davinder S. Jassal, Abdul Jaleel, Amir Ravandi
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2020)
Article
Oncology
Radhakrishnan Chandraprabha Vineetha, Sreedharan Hariharan, Abdul Jaleel, Mahesh Chandran, Raveendran Harikumaran Nair
FRONTIERS IN ONCOLOGY
(2020)