☆ 4.6 Article

Improving recruitment to clinical trials for regional and rural cancer patients through a regionally based clinical trials network

MEDICAL JOURNAL OF AUSTRALIA (2021)

Journal

MEDICAL JOURNAL OF AUSTRALIA

Volume 214, Issue 10, Pages 453-+

Publisher

WILEY

DOI: 10.5694/mja2.51078

Keywords

Clinical trials as topic; Cancer care facilities; Healthcare disparities; Rural health services

Categories

Medicine, General & Internal

Funding

Victorian Cancer Council
Victorian Cancer Agency

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Health Policy & Services

Factors responsible for healthcare avoidance among rural adults in the Eastern Region of North Carolina

Ashley E. Burch

Summary: This study investigates the reasons and factors influencing healthcare avoidance in rural areas. It finds that individuals with chronic illnesses are more likely to avoid healthcare due to cost, complexity, and privacy issues. Additionally, the perceived value of healthcare is associated with avoidance. Alternative methods such as telemedicine and mobile health clinics could improve healthcare continuity for rural residents.

JOURNAL OF COMMUNITY HEALTH (2022)

Add to Collection

Article Nursing

A mixed methods analysis of access barriers to dermatology care in a rural state

Melissa E. Cyr, Daryl Boucher, Shayna A. Korona, Barbara J. Guthrie, James C. Benneyan

Summary: In a rural health system with limited dermatology appointment availability, primary care provider diagnostic accuracy may be a key barrier to receiving dermatology care and achieving health outcomes. Older or non-working patients are more likely to remain unevaluated rather than seek care that is more convenient but geographically further away.

JOURNAL OF ADVANCED NURSING (2021)

Add to Collection

Article Oncology

Disparities in phase 1 cancer clinical trial enrollment

Subha Perni, Beverly Moy, Ryan D. Nipp

Summary: The study found disparities in phase 1 versus phase 2/3 trial enrollment, with Black, Hispanic/Latino, and male patients being less likely to enroll in phase 1 trials compared to White patients. The findings suggest a need for targeted interventions to improve access to and education about phase 1 trials for Black and Hispanic/Latino patients.

CANCER (2021)

Add to Collection

Article Management

Modelling policy interventions to improve patient access to rural dermatology care

Melissa E. Cyr, Daryl Boucher, Ashley A. Holmes, James C. Benneyan

Summary: Access to dermatology care is poor in the US, especially in rural areas with fewer dermatologists and limited resources. Various potential interventions have been analyzed through modeling, with some showing promising results in reducing appointment delays and travel for external care. This model-based analysis can help evaluate interventions and policies to address rural care disparities.

OPERATIONS MANAGEMENT RESEARCH (2021)

Add to Collection

Article Medicine, General & Internal

Examining clinical capability of township healthcare centres for rural health service planning in Sichuan, China: an administrative data analysis

Kun Zou, Zhanqi Duan, Ziwu Zhang, Jinliang Hu, Juying Zhang, Jay Pan, Chaojie Liu, Min Yang

Summary: This study aimed to evaluate the clinical capability of township healthcare centres (THCs) in rural China as a basis for rural health service planning. The results showed that the clinical capability of THCs did not meet the national standard, although THCs in the middle-developed county performed better than those in the rich and poor counties. THCs mainly provided services for infectious or inflammatory diseases, respiratory and digestive systems, but lacked clinical services related to injuries, poisoning, pregnancy, childbirth and surgeries.

BMJ OPEN (2023)

Add to Collection

Article Medicine, General & Internal

Views of nurses and other healthcare workers on interventions to reduce disrespectful maternity care in rural health facilities in Kilifi and Kisii counties, Kenya: analysis of a qualitative interview study

Adelaide M. Lusambili, Jerim Obure, Stefania Wisofschi, Lucy Nyaga, Kennedy Mulama, Marleen Temmerman

Summary: This qualitative study conducted in rural Kenya identified key areas for improving respectful maternity care, including continuous training, gender-responsive services, improved staffing levels, and adequate equipment and supplies. The findings highlight potential solutions that can be implemented to improve care for women during pregnancy, labor, and delivery, emphasizing the need for policy awareness to address challenges and promote implementation in different contexts.

BMJ OPEN (2022)

Add to Collection

Article Health Care Sciences & Services

Rural disparities in the quality of clinical care are notable and larger for males

Sarah MacCarthy, Marc N. Elliott, Steven C. Martino, David J. Klein, Amelia M. Haviland, Robert Weech-Maldonado, Jacob W. Dembosky, Loida Tamayo, Sarah Gaillot, Eric C. Schneider

Summary: This study examined the differences in quality of care between rural and urban Medicare Advantage (MA) enrollees and investigated whether these differences varied by gender. The findings showed that rural residents had worse scores than urban residents across all categories of measures. In some cases, the deficits associated with rural living were greater for males, while in other cases it was greater for females.

JOURNAL OF RURAL HEALTH (2023)

Add to Collection

Article Health Care Sciences & Services

Characterizing rural families' experiences receiving pediatric surgical care: A qualitative study

Christina Georgeades, Staci A. Young, Mochamad Muska Nataliansyah, Kyle J. Van Arendonk

Summary: This study qualitatively explored the experiences of rural families seeking surgical care for their children at a major children's hospital. The findings indicated that rural families faced difficulties with referrals, travel and employment, and benefited from technology use. These findings are important for developing tools to alleviate the challenges faced by rural families whose children require surgical care.

JOURNAL OF RURAL HEALTH (2023)

Add to Collection

Article Medicine, General & Internal

Healthcare utilisation, cancer screening and potential barriers to accessing cancer care in rural South West Nigeria: a cross-sectional study

Avinash Sharma, Olusegun Isaac Alatise, Kelli O'Connell, Samson Gbenga Ogunleye, Adewale Abdulwasiu Aderounmu, Marquerite L. Samson, Funmilola Wuraola, Olalekan Olasehinde, T. Peter Kingham, Mengmeng Du

Summary: Cancer burden is expected to double in sub-Saharan Africa by 2030, making access to healthcare services for cancer management a priority. A study conducted in a rural community in South West Nigeria revealed low rates of cancer screening activities, lack of medical insurance, and a positive correlation between higher personal income and increased cancer screening. Despite these challenges, most individuals had contact with primary healthcare doctors and access to media, suggesting potential for expanding community-based screening interventions and awareness.

BMJ OPEN (2021)

Add to Collection

Article Medicine, General & Internal

Recommendations for culturally safe clinical kidney care for First Nations Australians: a guideline summary

David J. Tunnicliffe, Samantha Bateman, Melissa Arnold-Chamney, Karen M. Dwyer, Martin Howell, Azaria Gebadi, Shilpa Jesudason, Janet Kelly, Kelly Lambert, Sandawan William Majoni, Dora Oliva, Kelli J. Owen, Odette Pearson, Elizabeth Rix, Ieyesha Roberts, Kimberly Taylor, Gary A. Wittert, Katherine Widders, Adela Yip, Jonathan Craig, Richard K. Phoon

Summary: First Nations Australians demonstrate remarkable strength and resilience despite the ongoing impacts of colonization. However, they continue to face higher rates of chronic kidney disease (CKD) compared to the general population. To address this issue, community involvement and equity in healthcare delivery, along with earlier detection and referral to specialists for CKD management, are essential.

MEDICAL JOURNAL OF AUSTRALIA (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Healthcare provider satisfaction with environmental conditions in rural healthcare facilities of 14 low- and middle-income countries

Donald Fejfar, Amy Guo, Emma Kelly, James Benjamin Tidwell, Oscar Ochieng, Ryan Cronk

Summary: This study examines the association between healthcare provider (HCP) satisfaction and water, sanitation, and hygiene (WaSH) infrastructure, cleanliness, and infection prevention and control (IPC) practices in rural healthcare facilities (HCFs) in low- and middle-income countries (LMICs). The study found that while HCPs were generally unsatisfied with water, sanitation, and hygiene infrastructure, they were less likely to report dissatisfaction with cleanliness and IPC practices. Factors such as inadequate supply and poor quality of WaSH resources contributed to provider dissatisfaction, highlighting the need for interventions to improve HCP satisfaction and ultimately patient outcomes.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2021)

Add to Collection

Article Hematology

Representation of the population in need for pivotal clinical trials in lymphomas

Mycal Casey, Lorriane Odhiambo, Nidhi Aggarwal, Mahran Shoukier, K. M. Islam, Jorge Cortes

Summary: Despite advances in cancer outcomes, there are significant health disparities in the treatment of lymphomas. This study examined the representation of different demographic groups in randomized controlled trials (RCTs) for lymphoma and found significant underrepresentation of black, Hispanic, and female patients. Geographic distribution of trials also limited access for patients in certain areas. Correcting enrollment disparities is crucial to ensure that the results of these trials are applicable to all populations.

BLOOD (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Factors affecting health care users' first contact with primary health care facilities in north eastern China, 2008-2018

Ran Liao, Yaqian Liu, Shunzhuang Peng, Xing Lin Feng

Summary: The study found that in Jilin, healthcare users did not prioritize primary healthcare facilities when seeking medical care, with low perceived quality as the main barrier. Neither social health insurance coverage nor contracting with family doctors influenced users' first choice of care.

BMJ GLOBAL HEALTH (2021)

Add to Collection

Review Rheumatology

Healthcare disparities in telemedicine for rheumatology care

Lesley E. Jackson, Maria Danila

Summary: This review summarizes recent literature on healthcare disparities in the delivery of rheumatology care through telemedicine in the past 2 years. Recent findings show that the COVID-19 pandemic has greatly impacted care delivery and led to an increase in telemedicine use in rheumatology practice. However, racial/ethnic minority groups and patients with lower socioeconomic status are underutilizing telemedicine services. While telemedicine has the potential to expand rheumatology services, addressing health equity and the digital divide is crucial.

CURRENT OPINION IN RHEUMATOLOGY (2022)

Add to Collection

Article Public, Environmental & Occupational Health

American Indians travel great distances for obstetrical care: Examining rural and racial disparities

Maggie L. Thorsen, Sean Harris, Janelle F. Palacios, Ronald G. McGarvey, Andreas Thorsen

Summary: Rural, American Indian/Alaska Native (AI/AN) people, especially those living on reservations, are more likely to bypass their local obstetric unit and travel longer distances to give birth, compared to white people. Factors such as health risks, insurance coverage, and rural location influence the likelihood of bypassing. However, despite the potential benefits of bypassing in connecting rural birthing people to appropriate care, healthcare access disparities based on rural and racial factors continue to persist.

SOCIAL SCIENCE & MEDICINE (2023)

Add to Collection

Article Health Care Sciences & Services

Exploring Australian regional cancer patients' experiences of clinical trial participation via telemedicine technology

Jin Joo Lee, Kate Burbury, Craig Underhill, Samuel Harris, Kylie Shackleton, Jacquiline McBurnie, Narelle McPhee, Felicity Osmond, Kathleen Wilkins, Paul Baden, Meinir Krishnasamy

Summary: This study explored the experiences of regional cancer patients and their carers in participating in teletrials. The findings suggest that bringing clinical trials to patients' homes is acceptable and valuable. Access to clinical trials and specialist cancer services were identified as important equity issues for regional cancer patients.

JOURNAL OF TELEMEDICINE AND TELECARE (2022)

Add to Collection

Review Oncology

Psychosocial well-being and supportive care needs of cancer patients and survivors living in rural or regional areas: a systematic review from 2010 to 2021

Shannen R. van der Kruk, Phyllis Butow, Ilse Mesters, Terry Boyle, Ian Olver, Kate White, Sabe Sabesan, Rob Zielinski, Bryan A. Chan, Kristiaan Spronk, Peter Grimison, Craig Underhill, Laura Kirsten, Kate M. Gunn

Summary: Recent research shows that rural people affected by cancer have unique unmet psychosocial needs relating to rurality. However, there was little evidence that rural cancer survivors report greater unmet needs than their urban counterparts. More population-based research is needed to establish whether uniquely rural unmet needs are due to general or cancer-specific factors.

SUPPORTIVE CARE IN CANCER (2022)

Add to Collection

Article Oncology

Teletrials, the new norm? Expert recommendations for teletrials into the future: Findings from the Clinical Oncology Society of Australia Clinical Trial Research Professionals Group Workshop

Natasha A. Roberts, Annette Cubitt, Dianne Lindsay, Kimberley Bury, Jacqueline Dixon, Chantal Gebbie, Cheryl-Ann Hawkins, Taylor Major, Sue Jenkins-Marsh, Bernadette Morris-Smith, Melanie Poxton, Sue Richmond, Delaine Smith, Adam Stoneley, Darshit A. Thaker, Elizabeth Wilson, Anne Woollett, Craig Underhill, Sabe Sabesan

Summary: The pilot of the Australasian Teletrial Model in Australia aimed to extend the reach of clinical trials for oncology patients through telemedicine. Experts shared their learnings from implementation during a workshop, identifying four key themes. Future directions include streamlining regulatory processes, improving implementation and monitoring, and expanding networks in Australia.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection

Article Oncology

Penpulimab, an anti-PD1 IgG1 antibody in the treatment of advanced or metastatic upper gastrointestinal cancers

Yulong Zheng, Anna Rachelle Austria Mislang, Jermaine Coward, Rasha Cosman, Adam Cooper, Craig Underhill, Jianqing Zhu, Jianping Xiong, Ou Jiang, Hong Wang, Yanru Xie, Yuefen Zhou, Xiaoping Jin, Baiyong Li, Zhongmin Maxwell Wang, Kon Yew Kwek, Dennis Xia, Yu Xia, Nong Xu

Summary: This study evaluated the safety and anti-tumor activity of penpulimab in patients with advanced upper gastrointestinal (UGI) cancers. The results showed that penpulimab monotherapy demonstrated acceptable safety and encouraged anti-tumor activity in these patients, warranting further exploration in a larger cohort of patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2022)

Add to Collection

Article Oncology

CCTG BR34: A Randomized Phase 2 Trial of Durvalumab and Tremelimumab With or Without Platinum-Based Chemotherapy in Patients With Metastatic NSCLC

Natasha B. Leighl, Scott A. Laurie, Glenwood D. Goss, Brett G. M. Hughes, Martin Stockler, Ming-Sound Tsao, David M. Hwang, Phillipe Joubert, Swati Kulkarni, Normand Blais, Anil A. Joy, Mihaela Mates, Punam Rana, Sunil K. Yadav, Craig Underhill, Christopher Lee, Penelope A. Bradbury, Andrea Hiltz, Janet Dancey, Keyue Ding, Francisco Vera-Badillo

Summary: This study compared the efficacy of combination chemoimmunotherapy and dual checkpoint inhibition as first-line treatment for metastatic NSCLC. The results showed similar overall survival between the two treatment approaches, but combination chemoimmunotherapy demonstrated better progression-free survival and overall response rate. However, the incidence of adverse events was higher in the combination chemoimmunotherapy group.

JOURNAL OF THORACIC ONCOLOGY (2022)

Add to Collection

Article Oncology

Associations between Smoking and Alcohol and Follicular Lymphoma Incidence and Survival: A Family-Based Case-Control Study in Australia

Michael K. Odutola, Marina T. van Leeuwen, Jennifer Turner, Fiona Bruinsma, John F. Seymour, Henry M. Prince, Samuel T. Milliken, Judith Trotman, Emma Verner, Campbell Tiley, Fernando Roncolato, Craig R. Underhill, Stephen S. Opat, Michael Harvey, Mark Hertzberg, Geza Benke, Graham G. Giles, Claire M. Vajdic

Summary: This population-based study found a positive association between smoking and the risk of follicular lymphoma (FL) incidence, as well as poorer overall survival and FL-specific survival. However, there was no evidence of an association between recent alcohol consumption and FL risk or survival. The findings highlight the importance of tobacco control activities to reduce FL incidence and improve patient outcomes.

CANCERS (2022)

Add to Collection

Article Immunology

Serious Underlying Medical Conditions and COVID-19 Vaccine Hesitancy: A Large Cross-Sectional Analysis from Australia

Daphne Day, Lisa Grech, Mike Nguyen, Nathan Bain, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Richard Blennerhassett, Louise Nott, Nada Hamad, Annette Tognela, David Hoffman, Amelia McCartney, Kate Webber, Jennifer Wong, Craig Underhill, Brett Sillars, Antony Winkel, Mark Savage, Bao Sheng Loe, Daniel Freeman, Eva Segelov

Summary: This study investigated vaccine uptake and hesitancy among individuals with serious and/or chronic health conditions, and found that unvaccinated individuals were more likely to be younger, female, have lower education and income, speak English as a second language, and reside in regional areas. Unvaccinated participants reported greater vaccine hesitancy and more negative perceptions toward vaccines. Disease-related vaccine concerns were associated with unvaccinated status and hesitancy.

VACCINES (2022)

Add to Collection

Article Oncology

Associations between early-life growth pattern and body size and follicular lymphoma risk and survival: a family-based case-control study

Michael K. Odutola, Marina T. van Leeuwen, Jennifer Turner, Fiona Bruinsma, John F. Seymour, H. Miles Prince, Samuel T. Milliken, Mark Hertzberg, Judith Trotman, Stephen S. Opat, Robert Lindeman, Fernando Roncolato, Emma Verner, Michael Harvey, Campbell Tiley, Craig R. Underhill, Geza Benke, Graham G. Giles, Claire M. Vajdic

Summary: This study investigated the association between gestational age, growth during childhood, body size, changes in body shape over time, and follicular lymphoma (FL) risk and survival. The findings suggest a weak association between elevated BMI and FL risk, but no association with all-cause or FL-specific mortality. Future studies incorporating biomarkers are needed to understand the role of body composition in FL etiology.

CANCER EPIDEMIOLOGY (2022)

Add to Collection

Article Immunology

COVID-19 Vaccine Hesitancy in Australian Patients with Solid Organ Cancers

Nathan Bain, Mike Nguyen, Lisa Grech, Daphne Day, Amelia McCartney, Kate Webber, Alastair Kwok, Sam Harris, Hieu Chau, Bryan Chan, Louise Nott, Nada Hamad, Annette Tognela, Craig Underhill, Bao Sheng Loe, Daniel Freeman, Eva Segelov

Summary: Vaccination is widely accepted among cancer patients, but vaccine hesitancy persists, especially among young, female, non-English dominant language-speaking, and regional patients. Vaccinated patients are more concerned about contracting COVID-19, while non-vaccinated patients are more worried about the safety and efficacy of the vaccine.

VACCINES (2022)

Add to Collection

Letter Oncology

Implementing national models utilizing telehealth for the conduct of clinical trials: A collaborative effort by the cancer sector in Victoria

Anne Woollett, Kate Burbury, Sam Harris, Jacqueline Dixon, Jessica Freeman, Jacqueline McBurnie, Mark Buzza, Stephen Jane, Craig Underhill

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2023)

Add to Collection

Letter Oncology

Is there a role for combined anti-PD-1/CTLA-4 checkpoint blockade in the management of advanced biliary tract cancers?

Oliver Klein, Damien Kee, Adnan Nagrial, Ben Markman, Craig Underhill, Michael Michael, Andreas Behren, Jodie Palmer, Niall C. C. Tebbutt, Matteo S. S. Carlino, Jonathan Cebon

CANCER (2023)

Add to Collection

Article Medicine, General & Internal

Workforce challenges across Victorian medical oncology services

Ian M. Collins, Rob Blum, Eva Segelov, Phillip Parente, Craig Underhill

Summary: This study investigated the current medical oncology workforce in Victoria and found a growing workload and inadequate resources to meet the demand, especially during the global pandemic. The study concludes that there is an urgent need to address the shortage of medical oncology workforce to ensure the quality and efficiency of cancer treatment.

INTERNAL MEDICINE JOURNAL (2023)

Add to Collection

Article Health Care Sciences & Services

Telehealth in cancer care during the COVID-19 pandemic

Kate Burbury, Peter Brooks, Leslie Gilham, Ilana Solo, Amanda Piper, Craig Underhill, Philip Campbell, Robert Blum, Stephen Brown, Frances Barnett, Javier Torres, Xiaofang Wang, William Poole, Anneke Grobler, Genevieve Johnston, Cassandra Beer, Hannah Cross, Zee Wan Wong

Summary: The study found high acceptability for both video and phone telehealth among cancer patients and clinicians, with video having higher satisfaction rates even though phone was more commonly used. Qualitative surveys revealed various barriers and enablers to the rapid implementation of telehealth.

JOURNAL OF TELEMEDICINE AND TELECARE (2022)

Add to Collection

Article Nutrition & Dietetics

Dietary intake of animal-based products and likelihood of follicular lymphoma and survival: A population-based family case-control study

Michael K. Odutola, Marina T. van Leeuwen, Julie K. Bassett, Fiona Bruinsma, Jennifer Turner, John F. Seymour, Henry Miles Prince, Samuel T. Milliken, Mark Hertzberg, Fernando Roncolato, Stephen S. Opat, Robert Lindeman, Campbell Tiley, Judith Trotman, Emma Verner, Michael Harvey, Craig R. Underhill, Geza Benke, Graham G. Giles, Claire M. Vajdic

Summary: This study examined the association between dietary intake of animal products and the risk and survival of follicular lymphoma. The results showed that there was no significant impact of consuming various animal products on FL risk and survival, except for a positive association between oily fish intake and FL risk.

FRONTIERS IN NUTRITION (2023)

Add to Collection

Article Oncology

GUIDE: a randomised non-comparative phase II trial of biomarker-driven intermittent docetaxel versus standard-of-care docetaxel in metastatic castration-resistant prostate cancer (clinical trial protocol)

Ciara Conduit, Blossom Mak, Wenjia Qu, Juliana Di Lulio, Ronan Burder, Matthias Bressel, Thomas Cusick, Haryana M. Dhillon, Richard De Abreu Lourenco, Craig Underhill, Javier Torres, Megan Crumbaker, Florian Honeyball, Anthony Linton, Ray Allen, Ian D. Davis, Susan J. Clark, Lisa G. Horvath, Kate L. Mahon

Summary: The study aims to assess the efficacy and safety of intermittent docetaxel chemotherapy guided by circulating mGSTP1 in men with metastatic castration-resistant prostate cancer. It plans to recruit 120 patients for randomised observation and evaluate the utility of mGSTP1 as a biomarker in guiding treatment.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.